Influenza and Pertussis Vaccination Status of Women in Immediate Postpartum and Caregivers
Conditions:   Pertussis/Whooping Cough;   Influenza Viral Infections Intervention:   Other: Survey Sponsor:   Central Hospital, Nancy, France Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 10, 2022 Category: Research Source Type: clinical trials

Statistical analysis plan for the OPTIMUM study: optimising immunisation using mixed schedules, an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
DiscussionA detailed, prospective statistical analysis plan (SAP) is presented for this Bayesian adaptive design. The plan was written by the trial statistician and details the study design, pre-specified adaptive elements, decision thresholds, statistical methods, and the simulations used to evaluate the operating characteristics of the trial. Application of this SAP will minimise bias and supports transparent and reproducible research.Trial registrationAustralia& New Zealand Clinical Trials Registry,ACTRN12617000065392. Registered on 12 January 2017Study protocolhttps://doi.org/10.1136/bmjopen-2020-042838 (Source: Trials)
Source: Trials - February 7, 2022 Category: Research Source Type: clinical trials

Safety and Immunogenicity of 2 Doses Versus 1 Dose of Acellular Pertussis Vaccines Containing Genetically-detoxified Pertussis Toxin in Young Adults Previously Primed With Acellular Pertussis Vaccines
Conditions:   Pertussis;   Vaccine-Preventable Diseases Interventions:   Drug: Pertagen®;   Drug: Revaxis® Sponsor:   University Hospital, Geneva Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2022 Category: Research Source Type: clinical trials