FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment —a pharmacokinetic-pharmacodynamic study
This study aims to understand whether there are any safety issues in administering baclofen to opioid-dependent individuals receiving methadone.MethodsOpiate-dependent individuals (DSM-5 severe opioid use disorder) maintained on methadone will be recruited from addiction services in northwest London (NHS and third sector providers). Participants will be medically healthy with no severe chronic obstructive pulmonary disease or type 2 respiratory failure, no current dependence on other substances (excluding nicotine), no current severe DSM-5 psychiatric disorders, and no contraindications for baclofen or 4800 IU vitamin D (p...
Source: Trials - October 18, 2022 Category: Research Source Type: clinical trials
High Oral Loading Dose of Cholecalciferol in Non-Alcoholic Fatty Liver Disease
Condition: Non-Alcoholic Fatty Liver Disease Interventions: Drug: Cholecalciferol; Drug: Placebo Sponsor: Tanta University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2022 Category: Research Source Type: clinical trials
