Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
Conditions: Systemic Lupus Erythematosus (SLE); Sjogren's Syndrome; Diffuse Scleroderma; Inflammatory Myopathy; ANCA Associated Systemic Vasculitis; Antiphospholipid Syndrome Intervention: Biological: BRL-301 Sponsors: Bioray Laboratories; Shanghai Changzheng Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 16, 2023 Category: Research Source Type: clinical trials
The HAVEN study —hydroxychloroquine in ANCA vasculitis evaluation—a multicentre, randomised, double-blind, placebo-controlled trial: study protocol and statistical analysis plan
DiscussionThis trial aims to explore Hydroxychloroquine as a treatment for patients with AAV. If effective, the need for immunosuppressive treatments such as prednisolone could be reduced. Hydroxychloroquine is safer, cheaper and has fewer adverse effects than conventional immunosuppressive treatments. This could improve patient outcomes while saving money for the NHS.Trial registrationISRCTN: ISRCTN79334891. Registered 07 June 2021.EudraCT: 2018-001268-40. Registered 13 September 2019.Clinicaltrials.gov: NCT04316494. Registered 20 March 2020. (Source: Trials)
Source: Trials - April 6, 2023 Category: Research Source Type: clinical trials
A randomised study of rituximab and belimumab sequential therapy in PR3 ANCA-associated vasculitis (COMBIVAS): design of the study protocol
DiscussionThis experimental medicine study provides a unique opportunity to gain detailed insights into the immunological mechanisms of belimumab-rituximab sequential therapy across multiple body compartments in the setting of AAV.Trial registrationClinicalTrials.gov NCT03967925. Registered on May 30, 2019. (Source: Trials)
Source: Trials - March 11, 2023 Category: Research Source Type: clinical trials
Longitudinal Study for Central Nervous System Vasculitis
Conditions: Central Nervous System Vasculitis; CNS Vasculitis; CNSV; Vasculitis Intervention: Sponsors: University of Pennsylvania; The Cleveland Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 21, 2023 Category: Research Source Type: clinical trials
