Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial
DiscussionThis is the first trial to evaluate this treatment combination by establishing the maximum tolerated dose and evaluating the efficacy of the combination treatment. M-PHP has shown to be a safe and effective treatment for UM patients with liver metastases and became the standard treatment option in our center. The combination of ICI with M-PHP is investigated in the currently described trial which might lead to a better treatment response both in and outside the liver.Trial RegistrationThis trial was registered in the US National Library of Medicine with identifierNCT04283890. Registered as per February 2020 - Ret...
Source: Trials - February 13, 2022 Category: Research Source Type: clinical trials
Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanoma
Condition: Metastatic Uveal Melanoma Interventions: Drug: Binimetinib; Drug: Belinostat Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Pfizer; Acrotech Biopharma Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2021 Category: Research Source Type: clinical trials
A Study of Concurrent Stereotactic Body Radiotherapy With Ipi and Nivo in Metastatic Uveal Melanoma
Condition: Uveal Melanoma Interventions: Radiation: stereotactic body radiotherapy; Drug: Immunotherapy Sponsor: California Pacific Medical Center Research Institute Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 14, 2021 Category: Research Source Type: clinical trials
