Early oral stepdown antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial): study protocol for a multicentre, randomised controlled, open-label, phase III, non-inferiority trial
DiscussionA finding of non-inferiority in efficacy of oral fluoroquinolones or trimethoprim-sulfamethoxazole versus IV standard of care antibiotics may hypothetically translate to wider adoption of a more cost-effective treatment strategy with better quality of life outcomes.Trial registrationClinicalTrials.govNCT05199324. Registered 20 January 2022. (Source: Trials)
Source: Trials - July 19, 2022 Category: Research Source Type: clinical trials
Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis
Condition: Endocarditis Infective Interventions: Drug: Cefaclor; Drug: Ciprofloxacin Tablets; Drug: Ciprofloxacin Injection; Drug: Clindamycin Oral Capsule; Drug: Clindamycin Injection; Drug: Dicloxacillin Oral Capsule; Drug: Dicloxacillin; Drug: Fusidic Acid Only Product in Oral Dose Form; Drug: F usidic Acid Only Product in Parenteral Dose Form; Drug: Levofloxacin Oral Tablet; Drug: Levofloxacin Injection; Drug: Linezolid Oral Tablet; Drug: Linezolid Injectable Product; Drug: Moxifloxacin tablet; Drug: Moxifloxacin Injectable Product; ...
Source: ClinicalTrials.gov - June 1, 2022 Category: Research Source Type: clinical trials
