Statistical analysis plan for the multicenter, open, randomized controlled clinical trial to assess the efficacy and safety of intravenous tirofiban vs aspirin in acute ischemic stroke due to tandem lesion, undergoing recanalization therapy by endovascular treatment (ATILA trial)
DiscussionThis will be the first clinical trial to assess the best antiplatelet therapy to avoid in-stent thrombosis after MT in patients with TL.Trial registrationThe trial is registered as NCT05225961. February, 7th, 2022. (Source: Trials)
Source: Trials - January 9, 2024 Category: Research Source Type: clinical trials
RIVAroxaban Versus Low-molecular Weight Heparin in Patients With Lower Limb Trauma Requiring Brace or CASTing
Conditions: Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Lower Limb Injury; Venous Thromboembolic Disease Interventions: Drug: Rivaroxaban 10 MG; Drug: Low Heparin Molecular Weight Sponsors: University Hospital, Angers Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials
Rivaroxaban in Elderly Chinese Venous Thromboembolism Patients
Conditions: Pulmonary Embolism; Venous Thromboembolism; Anticoagulant-induced Bleeding Interventions: Drug: Direct oral anticoagulant Sponsors: Peking Union Medical College Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials
Improving Emergency Department Testing for Deep Vein Thrombosis
Conditions: Deep Vein Thrombosis Sponsors: Dr. Kerstin de Wit; Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials
RIVAroxaban Versus Low-molecular Weight Heparin or Fondaparinux in Patients With Lower Limb Trauma Requiring Brace or CASTing
Conditions: Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Lower Limb Injury; Venous Thromboembolic Disease Interventions: Drug: Rivaroxaban 10 MG; Drug: Low Heparin Molecular Weight Sponsors: University Hospital, Angers Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials
An Observational Study to Learn More About How Safe Rivaroxaban is And How Well it Works in Children With Congenital Heart Disease Who Had a Heart Surgery Called the Fontan Procedure
Conditions: Prevention of Venous Thromboembolism; Congenital Heart Disease; Fontan Procedure; Children Interventions: Drug: Rivaroxaban (Xarelto, BAY59-7939) Sponsors: Bayer; Janssen Research& Development, LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials
CLEANer Aspiration for Pulmonary Embolism
Conditions: Pulmonary Embolism; Acute Pulmonary Embolism; Cardiovascular Diseases; Venous Thromboembolism Interventions: Device: Cleaner Pro Thrombectomy System Sponsors: Argon Medical Devices Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials
Endovascular aortic repair with sac embolization for the prevention of type II endoleaks (the EVAR-SE study): study protocol for a randomized controlled multicentre study in Germany
DiscussionAlthough preexisting studies repeatedly indicated a beneficial effect of SE on T2EL rates after EVAR, patient relevant outcomes have not been assessed until now. The present study is the first randomized controlled multicentre study to assess the impact of SE on quality of life. Further unique features include employment of easily assessable high-risk criteria, a contemporary follow-up protocol, and approval to use any commercially available coil material. Overcoming limitations of previous studies might help SE to be implemented in daily practice and to enhance patient safety.Trial registration ClinicalTrials.go...
Source: Trials - January 2, 2024 Category: Research Source Type: clinical trials
A randomized, controlled clinical study of low-molecular-weight heparin improving pregnancy outcomes in PCOS women undergoing IVF: study protocol
The objective of this study is to investigate the effect of LMWH on pregnancy outcomes after invitro fertilization-frozen embryo transfer (IVF-FET) in patients with polycystic ovary syndrome.MethodsA total of 356 PCOS women aged between 20 and 38 years which prepared for IVF followed with FET will be enrolled in the study. The patients, from four different hospitals stratified by age and body mass index (BMI), will be randomly divided into the study group who will be treated with LMWH started on the day of progesterone transformation (hormone therapy) during FET cycle and the control group without additional medicine. Seru...
Source: Trials - January 2, 2024 Category: Research Source Type: clinical trials
A PROSPECTIVE, MULTICENTER, SINGLE-ARM TRIAL FOR THE NEW SIZES OF BRIDGE STENTS FOR VERTEBRAL ARTERY STENOSIS: Bridge-MAX
Conditions: Brain Diseases; Vertebral Artery Thrombosis; Vertebral Artery Stenosis Interventions: Device: Bridge Sponsors: MicroPort NeuroTech Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 29, 2023 Category: Research Source Type: clinical trials
Apixaban for the Prevention of Latent Biological Valve Thrombosis
Conditions: Aortic Valve Replacement; Antithrombotic Therapy; Bioprosthetic Valve Thrombosis; Rapid Deployment Valves Interventions: Procedure: Aortic valve replacement surgery; Diagnostic Test: Computed tomography; Diagnostic Test: Echocardiography Sponsors: Clinical Hospital Centre Zagreb Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 28, 2023 Category: Research Source Type: clinical trials
Factor XI inhibiTion for the Prevention of Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty
Conditions: Knee Arthroplasty, Total Interventions: Drug: Enoxaparin; Drug: KN060 Low; Drug: KN060 Middle; Drug: KN060 Hight Sponsors: Suzhou Alphamab Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
Recurrent or Persistent Device Related Thrombus After Left Atrial Appendage Occlusion: The RE-DRT Study
Conditions: Percutaneous Left Atrial Appendage Occlusion (LAAO); Device-related Thrombus (DRT); Thromboembolic Event; Major Cardioembolic Events; Major Bleeding - TIMI Classification Sponsors: Institut universitaire de cardiologie et de pneumologie de Qu ébec, University Laval Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
Comparison of different intervention methods to reduce the incidence of venous thromboembolism: study protocol for a cluster-randomized, crossover trial
This study aims to compare the efficacy of two low molecular weight heparin (LMWH) regimens and additional intermittent pneumatic compression in preventing VTE among orthopedic trauma patients.Methods and analysisThis is a cluster-randomized crossover clinical study conducted in four hospitals in Shanghai from December 2019 to December 2023. The unit of randomization is orthopedic wards, and each ward will define a cluster. All clusters will implement four diverse intervention measures and one control measure in a given random sequence. Perioperative orthopedic trauma patients aged ≥ 18 years with stable vital signs, Cap...
Source: Trials - December 19, 2023 Category: Research Source Type: clinical trials
The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery.
Conditions: Left Atrial Appendage Thrombosis Interventions: Procedure: the left atrial appendage closure through surgery. Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
