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Molecular Biomarkers for the Evaluation of Colorectal Cancer.
PMID: 28165529 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 3, 2017 Category: Pathology Authors: Sepulveda AR, Hamilton SR, Allegra CJ, Grody W, Cushman-Vokoun AM, Funkhouser WK, Kopetz SE, Lieu C, Lindor NM, Minsky BD, Monzon FA, Sargent DJ, Singh VM, Willis J, Clark J, Colasacco C, Rumble RB, Temple-Smolkin R, Ventura CB, Nowak JA Tags: Am J Clin Pathol Source Type: research

Challenges to "Classic" Esophageal Candidiasis.
PMID: 28158394 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 31, 2017 Category: Pathology Authors: Alsomali MI, Arnold MA, Frankel WL, Graham RP, Hart PA, Lam-Himlin DM, Naini BV, Voltaggio L, Arnold CA Tags: Am J Clin Pathol Source Type: research

The Impact of an Electronic Ordering System on Blood Bank Specimen Rejection Rates.
PMID: 28158445 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 31, 2017 Category: Pathology Authors: Forest SK, Shirazi M, Wu-Gall C, Stotler BA Tags: Am J Clin Pathol Source Type: research

Improving Global Access to Diagnostic Testing: More Steps Forward.
PMID: 28122722 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 25, 2017 Category: Pathology Authors: Wilson ML, Fleming KA Tags: Am J Clin Pathol Source Type: research

Male Breast Cancer: A Single-Institution Clinicopathologic and Immunohistochemical Study.
CONCLUSIONS: The second malignancies in this cohort affected overall survival and suggest the possibility of other germline mutations in addition to BRCA2 in male patients with breast cancer. PMID: 28122723 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 24, 2017 Category: Pathology Authors: Serdy KM, Leone JP, Dabbs DJ, Bhargava R Tags: Am J Clin Pathol Source Type: research

Lab-in-a-Box: A Guide to Building Anatomic Pathology Networks in Resource-Limited Settings.
CONCLUSIONS: For global cancer care access and quality to advance, multiple stakeholders must commit to common goals and objectives and develop a comprehensive, sustainable system. African Strategies for Advancing Pathology will continue aligning stakeholders and advocating for meaningful policy changes to create positive, measurable, and long-lasting impact on global cancer care. PMID: 28122724 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 24, 2017 Category: Pathology Authors: Warner LC Tags: Am J Clin Pathol Source Type: research

Optimal Fixation Conditions and DNA Extraction Methods for MLPA Analysis on FFPE Tissue-Derived DNA.
CONCLUSIONS: FFPE-extracted DNA is well suitable for MLPA analysis, given that optimal tissue fixation and DNA extraction methods are chosen. PMID: 28122725 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 24, 2017 Category: Pathology Authors: Atanesyan L, Steenkamer MJ, Horstman A, Moelans CB, Schouten JP, Savola SP Tags: Am J Clin Pathol Source Type: research

HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer.
CONCLUSIONS: HER2 GPA performs accurately and is very useful to determine HER2 status in HER2 IHC and FISH double-equivocal breast cancer cases and identify HER2 heterogeneity. PMID: 28110280 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 21, 2017 Category: Pathology Authors: Hou Y, Nitta H, Li Z Tags: Am J Clin Pathol Source Type: research

Prognostic Significance of Residual Acute Myeloid Leukemia in Bone Marrow Samples Taken Prior to Allogeneic Hematopoietic Cell Transplantation.
CONCLUSIONS: Rigorous morphologic and karyotypic evaluation of pretransplant marrows is practical and important for posttransplant prognosis. PMID: 28108471 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2017 Category: Pathology Authors: Kovach AE, Brunner AM, Fathi AT, Chen YB, Hasserjian RP Tags: Am J Clin Pathol Source Type: research

Relapsed Acute Promyelocytic Leukemia Lacks "Classic" Leukemic Promyelocyte Morphology and Can Create Diagnostic Challenges.
CONCLUSIONS: Morphologic features of relapsed APL overlap with other types of acute myeloid leukemia, creating diagnostic challenges, especially if no history is available when relapsing patients seek treatment for care. PMID: 28108472 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - January 20, 2017 Category: Pathology Authors: Dayton VJ, McKenna RW, Yohe SL, Dolan MM, Courville E, Alvarez H, Linden MA Tags: Am J Clin Pathol Source Type: research

Distinct GATA1 Point Mutations in Monozygotic Twins With Down Syndrome and Transient Abnormal Myelopoiesis From a Triplet Pregnancy: A Case Report and Review of Literature.
CONCLUSIONS: Identical GATA1 mutations in cases of monozygotic twins are likely derived from twin-twin transmission. Distinct GATA1 mutations identified in our neonate twins with TAM provide unequivocal evidence of independent intra-utero GATA1 mutations, a completely different mechanism of development of TAM in monozygotic twins from previously reported cases. Interaction of trisomy 21 and GATA1 mutation produces TAM, but additional gene mutations are required for TAM to transform into DS-AMKL. PMID: 28028114 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Yin L, Lovell MA, Wilson ML, Wei Q, Liang X Tags: Am J Clin Pathol Source Type: research

Epidemiologic Analysis of Respiratory Viral Infections Mainly in Hospitalized Children and Adults in a Midwest University Medical Center After the Implementation of a 14-Virus Multiplex Nucleic Acid Amplification Test.
CONCLUSION: The ability to detect a wider range of respiratory viruses gave us a better understanding of the etiology of respiratory infections in our population, particularly for HRV and enhanced our ability to detect viral coinfection. PMID: 28028115 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Arbefeville S, Ferrieri P Tags: Am J Clin Pathol Source Type: research

Measures of Completeness and Accuracy of Clinical Information in Skin Biopsy Requisition Forms: An Analysis of 249 Cases.
CONCLUSIONS: In inflammatory dermatoses, providing high-quality clinical information on the RF promotes optimal histopathologic diagnostic performance and appropriate pathology service utilization. PMID: 28028116 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Romano RC, Novotny PJ, Sloan JA, Comfere NI Tags: Am J Clin Pathol Source Type: research

Standard Operating Procedure Utilization for Tuberculosis Microscopy in Mekelle City, North Ethiopia.
CONCLUSIONS: Tuberculosis microscopy was found to be substandard with clear gaps in documentation, sample collection, and processing. PMID: 28028117 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Weldu Y, Gebru H, Kahsay G, Teweldemedhn G, Hagos Y, Kahsay A Tags: Am J Clin Pathol Source Type: research

Rapid Evaluation of Platelet Function With T2 Magnetic Resonance.
CONCLUSIONS: T2MR may provide a clinically useful approach to diagnose QPDs using small volumes of whole blood, while also providing new insight into platelet biology not evident using plasma-based platelet aggregation tests. PMID: 28028118 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Cuker A, Husseinzadeh H, Lebedeva T, Marturano JE, Massefski W, Lowery TJ, Lambert MP, Abrams CS, Weisel JW, Cines DB Tags: Am J Clin Pathol Source Type: research

Inactivating Mutations of RB1 and TP53 Correlate With Sarcomatous Histomorphology and Metastasis/Recurrence in Gastrointestinal Stromal Tumors.
CONCLUSIONS: TP53 and RB1 mutations seem to be restricted to high-risk/malignant GISTs and occur at an equal although relatively low frequency. PMID: 28028119 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Merten L, Agaimy A, Moskalev EA, Giedl J, Kayser C, Geddert H, Schaefer IM, Cameron S, Werner M, Ströbel P, Hartmann A, Haller F Tags: Am J Clin Pathol Source Type: research

CCND1-IGH Fusion-Amplification and MYC Copy Number Gain in a Case of Pleomorphic Variant Mantle Cell Lymphoma.
CONCLUSIONS: CCND1-IGH fusion-amplification with MYC copy number gain is extremely rare and may play a role in disease progression in a subset of MCL cases. PMID: 28028120 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 27, 2016 Category: Pathology Authors: Miao Y, Lin P, Wang W, Jeffrey Medeiros L, Lu X Tags: Am J Clin Pathol Source Type: research

Disseminated Intravascular Coagulation.
CONCLUSIONS: The massive tissue factor stimulus results in excess intravascular thrombin, which overcomes the anticoagulant systems and leads to thrombosis. Because of consumption of coagulation factors and platelets, DIC also has a hemorrhagic phase. Treatment of the bleeding patient with DIC is supportive with the use of blood components. PMID: 28013226 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 24, 2016 Category: Pathology Authors: Boral BM, Williams DJ, Boral LI Tags: Am J Clin Pathol Source Type: research

Immunohistochemical Detection of ROS1 Fusion.
CONCLUSIONS: Since ROS1 rearrangement is an infrequent event, immunohistochemistry is a cost-effective screening method. Confirmation of all positive and equivocal/weak staining with molecular assays would exclude the false-positive cases. PMID: 28007702 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 21, 2016 Category: Pathology Authors: Su Y, Goncalves T, Dias-Santagata D, Hoang MP Tags: Am J Clin Pathol Source Type: research

Immunohistochemistry Is Rarely Justified for the Diagnosis of Viral Infections.
CONCLUSIONS: These findings suggest that IHC for viral infections without a high degree of clinical or histologic suspicion is unnecessary in most cases. PMID: 28007703 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 21, 2016 Category: Pathology Authors: Solomon IH, Hornick JL, Laga AC Tags: Am J Clin Pathol Source Type: research

Where the Wild Things Aren't: Loss of Biodiversity, Emerging Infectious Diseases, and Implications for Diagnosticians.
PMID: 27940425 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 10, 2016 Category: Pathology Authors: Granter SR, Ostfeld RS, Milner DA Tags: Am J Clin Pathol Source Type: research

Laboratory Tests Ordering Pattern by Medical Residents From a Brazilian University Hospital.
CONCLUSIONS: Number of tests and repetition were both high, imposing costs, discomfort, and risks to patients, thus warranting further investigation. PMID: 27940426 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 10, 2016 Category: Pathology Authors: Sales MM, Taniguchi LU, Fonseca LA, Ferreira-Junior M, Aguiar FJ, Sumita NM, Lichtenstein A, Duarte AJ Tags: Am J Clin Pathol Source Type: research

Discrepancies Between Clinical Diagnoses and Autopsy Findings in Critically Ill Children: A Prospective Study.
CONCLUSIONS: Our results emphasize the importance of autopsy to clarify the cause of death and its potential contribution to improvement of team performance and quality of care. PMID: 27940427 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 10, 2016 Category: Pathology Authors: Carlotti AP, Bachette LG, Carmona F, Manso PH, Vicente WV, Ramalho FS Tags: Am J Clin Pathol Source Type: research

Pleuromediastinal Epithelial-Myoepithelial Carcinomas: A Clinicopathologic and Immunohistochemical Study of Two Cases.
CONCLUSIONS: These cases highlight the ubiquitous distribution of salivary gland-type tumors in the thoracic cavity. These tumors should be included in the differential diagnosis of thoracic neoplasms also in locations other than the lung. PMID: 27864182 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 17, 2016 Category: Pathology Authors: Weissferdt A, Kalhor N, Moran CA Tags: Am J Clin Pathol Source Type: research

Coexpressed High Levels of VEGF-C and Active MMP-9 Are Associated With Lymphatic Spreading and Local Invasiveness of Papillary Thyroid Carcinoma.
CONCLUSIONS: Association of coexpressed high levels of VEGF-C and active MMP-9 with lymphatic spreading and local invasiveness of PTC suggests their potential usefulness as predictive biomarkers of aggressive PTC behavior. PMID: 27806941 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - November 2, 2016 Category: Pathology Authors: Šelemetjev S, Đorić I, Paunović I, Tatić S, Cvejić D Tags: Am J Clin Pathol Source Type: research

Prognostic Value of E-Cadherin and β-Catenin in Triple-Negative Breast Cancer.
CONCLUSIONS: E-cadherin and β-catenin expression provides discriminative prognostic power independent of conventional pathologic factors, thus further reinforcing the important role of cell adhesion molecules in the process of tumor metastasis, especially in TNBC. PMID: 27780797 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 25, 2016 Category: Pathology Authors: Shen T, Zhang K, Siegal GP, Wei S Tags: Am J Clin Pathol Source Type: research

Inconsistent Results With Different Secondary Reflex Assays for Resolving HER2 Status.
CONCLUSIONS: Use of different control loci for ISH is associated with discordant results, and PCR is more likely to classify cases as nonamplified, possibly due to contamination with nontumor cells. While resolution of HER2-equivocal results is desirable from a clinical perspective, different secondary reflex assays yield different results, and the correlation of these results with clinical outcomes is unknown. PMID: 27773872 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 22, 2016 Category: Pathology Authors: Willmore-Payne C, Damjanovich-Colmenares K, Pasi AV, Werner TL, Gulbahce HE, Downs-Kelly E, Geiersbach KB Tags: Am J Clin Pathol Source Type: research

Performance Characteristics of the Reverse Syphilis Screening Algorithm in a Population With a Moderately High Prevalence of Syphilis.
CONCLUSIONS: Despite a 1.0% false-reactive rate, the reverse syphilis algorithm detected 21 patients with possible latent syphilis that may have gone undetected by traditional syphilis screening. PMID: 27773873 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 22, 2016 Category: Pathology Authors: Rourk AR, Nolte FS, Litwin CM Tags: Am J Clin Pathol Source Type: research

Data-Driven Iterative Refinement of Bone Marrow Testing Protocols Leads to Progressive Improvement in Cytogenetic and Molecular Test Utilization.
CONCLUSIONS: Data-driven iterative revision of protocols further improves test utilization and performance, while reducing cost. Analysis of testing data can be used to continuously improve test ordering decisions. PMID: 27769956 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 20, 2016 Category: Pathology Authors: Seegmiller AC, Kim AS, Mosse CA, Shaver AC, Thompson MA, Li S, Head DR, Zutter MM Tags: Am J Clin Pathol Source Type: research

Immunohistochemistry Improves the Detection of Adenovirus in Gastrointestinal Biopsy Specimens From Hematopoietic Stem Cell Transplant Recipients.
CONCLUSIONS: In HSCT recipients, cytopathic changes of adenovirus may be easily missed in H&E-stained sections of gastrointestinal biopsy specimens. Thus, the routine use of adenovirus immunohistochemistry in all cases is recommended. Both cases of CMV infection were apparent on H&E evaluation, so the judicious use of immunohistochemical stains for CMV in selected cases may be considered. PMID: 27744342 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 15, 2016 Category: Pathology Authors: Weidner AS, Panarelli NC, Rennert H, Jessurun J, Yantiss RK Tags: Am J Clin Pathol Source Type: research

Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group.
CONCLUSIONS: Standardization of diagnostic investigations will increase homogeneity in patient care and provide a foundation for future clinical research in this rapidly evolving therapeutic area. Streamlining diagnostic approaches in the most efficient and cost-effective manner will also result in significant cost saving for the health care system. PMID: 27686169 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Busque L, Porwit A, Day R, Olney HJ, Leber B, Éthier V, Sirhan S, Foltz L, Prchal J, Kamel-Reid S, Karsan A, Gupta V Tags: Am J Clin Pathol Source Type: research

CAL2 Immunohistochemical Staining Accurately Identifies CALR Mutations in Myeloproliferative Neoplasms.
CONCLUSIONS: Immunohistochemistry in routinely processed bone marrow biopsy specimens for mutated CALR is feasible and accurately identifies mutated cases, including rare cases with additional driver mutations. PMID: 27686170 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Nomani L, Bodo J, Zhao X, Durkin L, Loghavi S, Hsi ED Tags: Am J Clin Pathol Source Type: research

Detection of CALR Mutation in Clonal and Nonclonal Hematologic Diseases Using Fragment Analysis and Next-Generation Sequencing.
CONCLUSIONS: Screening for CALR mutations is essential in BCR-ABL-negative MPNs since it not only provides valuable diagnostic and prognostic information but also identifies potential treatment targets. Since this study describes the importance of screening for known and novel biomarkers, we described in detail three methods that could be easily integrated into a clinical laboratory. PMID: 27686171 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Gardner JA, Peterson JD, Turner SA, Soares BL, Lancor CR, Dos Santos LL, Kaur P, Ornstein DL, Tsongalis GJ, de Abreu FB Tags: Am J Clin Pathol Source Type: research

Significant Reduction in Preanalytical Errors for Nonphlebotomy Blood Draws After Implementation of a Novel Integrated Specimen Collection Module.
CONCLUSIONS: Implementation of a customized specimen collection module led to a significant reduction in preanalytical errors. Improved compliance with the system may lead to further reductions in error rates. PMID: 27686172 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Le RD, Melanson SE, Petrides AK, Goonan EM, Bixho I, Landman AB, Brogan AM, Bates DW, Tanasijevic MJ Tags: Am J Clin Pathol Source Type: research

Effect of On-Site Support on Laboratory Practice for Human Immunodeficiency Virus, Tuberculosis, and Malaria Testing.
CONCLUSIONS: On-site support significantly improved laboratory practices in conducting HIV rapid testing, TB sputum microscopy, and malaria microscopy. It could be an effective method for improving laboratory practice, without taking limited laboratory staff away from health facilities for training. PMID: 27686173 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Burnett SM, Mbonye MK, Martin R, Ronald A, Zawedde-Muyanja S, Willis KS, Colebunders R, Manabe YC, Weaver MR Tags: Am J Clin Pathol Source Type: research

Clinical Action Curves:  Measuring the Magnitude of Physician Response to Abnormal Laboratory Results.
CONCLUSIONS: Clinical action curves and limits provide practical, objective tools for describing physician responses to test values. Results suggest that many normal results are treated as abnormal and vice versa; such discrepancies require further scrutiny and ultimately reconciliation via altered reference ranges or altered practice patterns. PMID: 27686174 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Morgen EK, Naugler C Tags: Am J Clin Pathol Source Type: research

Spindle Cell Lipomas Arising at Atypical Locations.
CONCLUSIONS: SCLs may arise in the trunk, lower extremities, and distal upper extremities. While most SCLs arising in classic sites occur in male patients, there is a relatively equal sex distribution in tumors at atypical sites. Pathologists should be aware that SCLs arise at atypical locations to avoid misclassification as other lipomatous neoplasms, including atypical lipomatous tumor. PMID: 27686175 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Ud Din N, Zhang P, Sukov WR, Sattler CA, Jenkins SM, Doyle LA, Folpe AL, Fritchie KJ Tags: Am J Clin Pathol Source Type: research

Stromal PD-L1 Expression Is Associated With Better Disease-Free Survival in Triple-Negative Breast Cancer.
CONCLUSIONS: PD-L1 expression is seen in a high proportion of TNBCs and associated with better DFS. PMID: 27686176 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Li X, Wetherilt CS, Krishnamurti U, Yang J, Ma Y, Styblo TM, Meisel JL, Peng L, Siddiqui MT, Cohen C, Aneja R Tags: Am J Clin Pathol Source Type: research

Phosphohistone-H3 Proliferation Index Is Superior to Mitotic Index and MIB-1 Expression as a Predictor of Recurrence in Human Meningiomas.
CONCLUSIONS: PHH3 immunostaining allowed for the easiest, fastest, and most objective assessment of proliferation and proved to be the most accurate and reliable method for predicting recurrence in patients resected for meningiomas. PMID: 27686177 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 1, 2016 Category: Pathology Authors: Winther TL, Arnli MB, Salvesen Ø, Torp SH Tags: Am J Clin Pathol Source Type: research

A Review of Outcomes for Colorectal Adenomas.
CONCLUSIONS: Although greater than 50% of those with colorectal adenomas will have additional adenomas, few progress to invasive tumor or die of colorectal cancer. PMID: 27677272 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 27, 2016 Category: Pathology Authors: Vollmer RT Tags: Am J Clin Pathol Source Type: research

Pathology Resident Perspectives on Feedback and a Proposed Trainee Curriculum on Giving Feedback.
CONCLUSIONS: Feedback is an important component of assessment and reflective practice. Pathology trainees believe that being specific and balanced were characteristics of effective feedback. It is important to provide training on giving effective feedback to pathology trainees. PMID: 27614665 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Prayson RA, Rowe JJ Tags: Am J Clin Pathol Source Type: research

Genomic Copy Number Analysis of HER2-Equivocal Breast Cancers.
CONCLUSIONS: A combination of hyperdiploidy and segmental copy number gains contributes to HER2 ISH-equivocal results in most breast cancers. Cases in which HER2 copy number gain is not corroborated by genomic analysis suggest the presence of other contributing variables influencing ISH results. Genomic copy number analysis also implicates non-HER2 oncogenic drivers in many cases that are HER2 equivocal. PMID: 27614666 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Geiersbach KB, Willmore-Payne C, Pasi AV, Paxton CN, Werner TL, Xu X, Wittwer CT, Gulbahce HE, Downs-Kelly E Tags: Am J Clin Pathol Source Type: research

Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall.
CONCLUSIONS: Although EMC and AdCC can both contain spherical matrix globules, close evaluation of the cytomorphology of the globules and their relationship to surrounding cells provides a clue to distinguish the two neoplasms. PMID: 27614667 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Aisagbonhi OA, Tulecke MA, Wilbur DC, Goldar-Najafi A, Iqbal S, Sadow PM, Faquin WC Tags: Am J Clin Pathol Source Type: research

Hyaline Protoplasmic Astrocytopathy: A Clinicopathologic Study.
CONCLUSIONS: The current series supports an association of Aicardi syndrome (21% of cases) and focal cortical dysplasia (100% of cases) and hyaline protoplasmic astrocytopathy. PMID: 27614668 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Prayson RA Tags: Am J Clin Pathol Source Type: research

Introducing a Virtual Reality Experience in Anatomic Pathology Education.
CONCLUSIONS: Our novel method provides the foundation to create a robust teaching library. AP is inherently a visual discipline, and by building on the strengths of traditional teaching methods, our dynamic approach allows viewers to appreciate the procedural actions involved in specimen processing. PMID: 27594429 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 4, 2016 Category: Pathology Authors: Madrigal E, Prajapati S, Hernandez-Prera JC Tags: Am J Clin Pathol Source Type: research

Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences: A Model for Pathology Services in Sub-Saharan Africa.
CONCLUSIONS: Our multidisciplinary approach can be a model for strong pathology services that provide direct, real-time support to clinical care and research in SSA. PMID: 27594430 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 4, 2016 Category: Pathology Authors: Montgomery ND, Liomba NG, Kampani C, Krysiak R, Stanley CC, Tomoka T, Kamiza S, Dhungel BM, Gopal S, Fedoriw Y Tags: Am J Clin Pathol Source Type: research

High Tumor Vascular Endothelial Growth Factor Expression Is Associated With Poorer Clinical Outcomes in Resected T3 Gastric Adenocarcinoma.
CONCLUSIONS: High VEGF expression is associated with a higher risk of recurrence and shorter survival in resected T3 GA. These findings may provide a foundation for evaluating VEGF-targeted molecular therapies in T3 GA. PMID: 27543975 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Lin C, Zhang Z, Xu Y, Wang R, Chen S, Gao J, Wang D, Huang Q, Tu X, Wang L Tags: Am J Clin Pathol Source Type: research

A Library of Rare α1-Antitrypsin (AAT) Variant Phenotypes to Aid in the Diagnosis of AAT Deficiency.
CONCLUSIONS: Our results add to the reference library to identify the rare variant phenotypes of AAT protein. This report will guide clinical laboratories for proper assessment of rare variants and in turn contribute to accurate diagnosis and management of AAT deficiency. PMID: 27543976 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Akbas N, Gonzalez G, Buffone GJ, Grenache DG, Devaraj S Tags: Am J Clin Pathol Source Type: research

MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma:  A Comparison With AMACR.
CONCLUSIONS: MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma, especially when AMACR is not discriminatory. PMID: 27543977 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Goldstein J, Goyal R, Roland JT, Gellert LL, Clark PE, Hameed O, Giannico GA Tags: Am J Clin Pathol Source Type: research

Utility of Examination of Biopsy Tracts in Osteosarcoma Resection Specimens.
CONCLUSIONS: Pathologists do not need to submit sections of resected biopsy tracts unless there is clinical or gross evidence that would warrant further examination. PMID: 27543978 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Cates JM Tags: Am J Clin Pathol Source Type: research