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Pathology Resident Perspectives on Feedback and a Proposed Trainee Curriculum on Giving Feedback.
CONCLUSIONS: Feedback is an important component of assessment and reflective practice. Pathology trainees believe that being specific and balanced were characteristics of effective feedback. It is important to provide training on giving effective feedback to pathology trainees. PMID: 27614665 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Prayson RA, Rowe JJ Tags: Am J Clin Pathol Source Type: research

Genomic Copy Number Analysis of HER2-Equivocal Breast Cancers.
CONCLUSIONS: A combination of hyperdiploidy and segmental copy number gains contributes to HER2 ISH-equivocal results in most breast cancers. Cases in which HER2 copy number gain is not corroborated by genomic analysis suggest the presence of other contributing variables influencing ISH results. Genomic copy number analysis also implicates non-HER2 oncogenic drivers in many cases that are HER2 equivocal. PMID: 27614666 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Geiersbach KB, Willmore-Payne C, Pasi AV, Paxton CN, Werner TL, Xu X, Wittwer CT, Gulbahce HE, Downs-Kelly E Tags: Am J Clin Pathol Source Type: research

Fine-Needle Aspiration of Epithelial-Myoepithelial Carcinoma of the Parotid Gland With Prominent Adenoid Cystic Carcinoma-Like Cribriform Features: Avoiding a Diagnostic Pitfall.
CONCLUSIONS: Although EMC and AdCC can both contain spherical matrix globules, close evaluation of the cytomorphology of the globules and their relationship to surrounding cells provides a clue to distinguish the two neoplasms. PMID: 27614667 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Aisagbonhi OA, Tulecke MA, Wilbur DC, Goldar-Najafi A, Iqbal S, Sadow PM, Faquin WC Tags: Am J Clin Pathol Source Type: research

Hyaline Protoplasmic Astrocytopathy: A Clinicopathologic Study.
CONCLUSIONS: The current series supports an association of Aicardi syndrome (21% of cases) and focal cortical dysplasia (100% of cases) and hyaline protoplasmic astrocytopathy. PMID: 27614668 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 10, 2016 Category: Pathology Authors: Prayson RA Tags: Am J Clin Pathol Source Type: research

Introducing a Virtual Reality Experience in Anatomic Pathology Education.
CONCLUSIONS: Our novel method provides the foundation to create a robust teaching library. AP is inherently a visual discipline, and by building on the strengths of traditional teaching methods, our dynamic approach allows viewers to appreciate the procedural actions involved in specimen processing. PMID: 27594429 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 4, 2016 Category: Pathology Authors: Madrigal E, Prajapati S, Hernandez-Prera JC Tags: Am J Clin Pathol Source Type: research

Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences: A Model for Pathology Services in Sub-Saharan Africa.
CONCLUSIONS: Our multidisciplinary approach can be a model for strong pathology services that provide direct, real-time support to clinical care and research in SSA. PMID: 27594430 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 4, 2016 Category: Pathology Authors: Montgomery ND, Liomba NG, Kampani C, Krysiak R, Stanley CC, Tomoka T, Kamiza S, Dhungel BM, Gopal S, Fedoriw Y Tags: Am J Clin Pathol Source Type: research

High Tumor Vascular Endothelial Growth Factor Expression Is Associated With Poorer Clinical Outcomes in Resected T3 Gastric Adenocarcinoma.
CONCLUSIONS: High VEGF expression is associated with a higher risk of recurrence and shorter survival in resected T3 GA. These findings may provide a foundation for evaluating VEGF-targeted molecular therapies in T3 GA. PMID: 27543975 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Lin C, Zhang Z, Xu Y, Wang R, Chen S, Gao J, Wang D, Huang Q, Tu X, Wang L Tags: Am J Clin Pathol Source Type: research

A Library of Rare α1-Antitrypsin (AAT) Variant Phenotypes to Aid in the Diagnosis of AAT Deficiency.
CONCLUSIONS: Our results add to the reference library to identify the rare variant phenotypes of AAT protein. This report will guide clinical laboratories for proper assessment of rare variants and in turn contribute to accurate diagnosis and management of AAT deficiency. PMID: 27543976 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Akbas N, Gonzalez G, Buffone GJ, Grenache DG, Devaraj S Tags: Am J Clin Pathol Source Type: research

MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma:  A Comparison With AMACR.
CONCLUSIONS: MAGI-2 could represent a useful adjunct for diagnosis of prostatic adenocarcinoma, especially when AMACR is not discriminatory. PMID: 27543977 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Goldstein J, Goyal R, Roland JT, Gellert LL, Clark PE, Hameed O, Giannico GA Tags: Am J Clin Pathol Source Type: research

Utility of Examination of Biopsy Tracts in Osteosarcoma Resection Specimens.
CONCLUSIONS: Pathologists do not need to submit sections of resected biopsy tracts unless there is clinical or gross evidence that would warrant further examination. PMID: 27543978 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Cates JM Tags: Am J Clin Pathol Source Type: research

Comparison of HER2 Dual-Color and Fluorescence In Situ Hybridization in Breast Cancer:  A Cohort Study Emphasizing Equivocal Cases.
CONCLUSIONS: In our cohort enriched for equivocal cases, the numerical values of HER2 copy number were significantly lower using DISH, resulting in discordances. Although DISH is a valid method, variations with FISH may be expected in high-equivocal cases and in quality assurance activities. PMID: 27543979 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Shao T, Wood M, Wing A, Hnatovska M, Mendes M, Brendan Mullen J, Chang MC Tags: Am J Clin Pathol Source Type: research

EDTA Treatment of Serum Unmasks Complement-Mediated Prozone Inhibition in Human Leukocyte Antigen Antibody Testing.
CONCLUSIONS: EDTA serum pretreatment mitigated complement-mediated prozone inhibition and improved accurate HLA antibody detection. The background reactivity and the false-negative rate of the assay appear unchanged. PMID: 27543980 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Anani WQ, Zeevi A, Lunz JG Tags: Am J Clin Pathol Source Type: research

Evaluation of the V8 E-Class, a Novel Automated Capillary Isoelectric Focusing Instrument for Hemoglobinopathy Screening.
CONCLUSIONS: Good analytical performance was demonstrated for this novel CIEF application for hemoglobinopathy screening. Method comparison showed generally good correlation but highlights the need for standardization. Finally, software optimization could further add to its use for routine hemoglobinopathy screening. PMID: 27543981 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Schiemsky T, Brusselmans C, Nackers E, Vermeersch P, Poesen K, Desmet KJ, Boeckx N, Kieffer DM Tags: Am J Clin Pathol Source Type: research

Fine-Needle Aspiration Cytology of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma Is Cytomorphologically Distinct From the Invasive Counterpart.
CONCLUSIONS: There is a distinction in the cytologic diagnosis between noninvasive and invasive FVPTC. The invasive subtype was diagnosed by FNA as suspicious for PTC or PTC in nearly 75% of cases, while only one (4%) case for the noninvasive subtype was diagnosed as suspicious for PTC (P < .05). PMID: 27543982 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Ibrahim AA, Wu HH Tags: Am J Clin Pathol Source Type: research

Impact of Implementing the Paris System for Reporting Urine Cytology in the Performance of Urine Cytology:  A Correlative Study of 124 Cases.
CONCLUSIONS: The PSRUC seems to improve the performance of urine cytology by limiting the AUC category to cases that are more strongly associated with HGUC. PMID: 27543983 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Hassan M, Solanki S, Kassouf W, Kanber Y, Caglar D, Auger M, Brimo F Tags: Am J Clin Pathol Source Type: research

Knowledge of Patients' Human Papillomavirus Status at the Time of Cytologic Review Significantly Affects the Performance of Cervical Cytology in the ATHENA Study.
CONCLUSIONS: Unblinded cytology increases overall sensitivity with either cotesting or HPV primary screening; specificity is either slightly improved or is not affected by unblinding. PMID: 27543984 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 22, 2016 Category: Pathology Authors: Wright TC, Stoler MH, Aslam S, Behrens CM Tags: Am J Clin Pathol Source Type: research

Heterogeneity of Metastatic Melanoma:  Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1.
CONCLUSIONS: Overall, in melanoma lymph node metastases, MITF protein expression was not tightly correlated with its gene targets. Moreover, the immunoreactivity for MITF, compared with MART-1 and HMB-45, was retained, supporting immunohistochemical detection of MITF as a more sensitive method of detecting metastatic melanoma. PMID: 27515936 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 11, 2016 Category: Pathology Authors: Zand S, Buzney E, Duncan LM, Dadras SS Tags: Am J Clin Pathol Source Type: research

Algorithmic Approach With Clinical Pathology Consultation Improves Access to Specialty Care for Patients With Systemic Lupus Erythematosus.
CONCLUSIONS: Clinical pathology intervention and case triaging can improve access to care in a county health care system. PMID: 27510715 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 10, 2016 Category: Pathology Authors: Chen L, Welsh KJ, Chang B, Kidd L, Kott M, Zare M, Carroll K, Nguyen A, Wahed A, Tholpady A, Pung N, McKee D, Risin SA, Hunter RL Tags: Am J Clin Pathol Source Type: research

An Assessment of the State of Current Practice in Coagulation Laboratories.
CONCLUSIONS: These results may help laboratories negotiate for additional technologists if needed, prepare for Ebola specimens, and manage the demand for laboratory tests for new DOAC anticoagulants. PMID: 27510716 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 10, 2016 Category: Pathology Authors: Zantek ND, Hayward CP, Simcox TG, Smock KJ, Hsu P, Van Cott EM Tags: Am J Clin Pathol Source Type: research

Opportunities for Improvement in Pathology Reporting of Childhood Nonrhabdomyosarcoma Soft Tissue Sarcomas: A Report From Children's Oncology Group (COG) Study ARST0332.
CONCLUSIONS: This study reveals significant opportunity to improve the quality of pathology reports in young patients with soft tissue tumors. Use of templates or checklists improves completeness of reports. PMID: 27510717 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 10, 2016 Category: Pathology Authors: Black JO, Coffin CM, Parham DM, Hawkins DS, Speights RA, Spunt SL Tags: Am J Clin Pathol Source Type: research

Massive Transfusion Protocol:  Communication Ordering Practice Survey (MTP COPS).
CONCLUSIONS: Although CPOE-based MTP ordering is offered by nearly half of US level I trauma centers, verbal/telephone ordering is by far the preferred mechanism. Our survey identifies confusion surrounding blood component needs during MTP resuscitation as an opportunity for practice improvement. PMID: 27510718 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 10, 2016 Category: Pathology Authors: Tran MH, Vossoughi S, Harm S, Dunbar N, Fung M Tags: Am J Clin Pathol Source Type: research

Development, Implementation, and Evaluation of an Interdisciplinary Women's Health and Laboratory Course.
CONCLUSIONS: Case-based discussions gave learners a better understanding of the function and complexity of the clinical laboratories, and multidisciplinary facilitation highlighted the value of interacting with laboratory professionals to enhance clinical care. PMID: 27498758 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 7, 2016 Category: Pathology Authors: Guarner J, Winkler AM, Flowers L, Hill CE, Ellis JE, Workowski K, Reid MD, Goedken J Tags: Am J Clin Pathol Source Type: research

Challenges of Maintaining Good Clinical Laboratory Practices in Low-Resource Settings:  A Health Program Evaluation Framework Case Study From East Africa.
CONCLUSIONS: These findings demonstrate that GCLP laboratory service provision in this setting is hampered by delays in biomedical engineer support, delays and extra costs in commodity procurement, low testing throughput, and high personnel turnover. PMID: 27473737 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Zhang HL, Omondi MW, Musyoka AM, Afwamba IA, Swai RP, Karia FP, Muiruri C, Reddy EA, Crump JA, Rubach MP Tags: Am J Clin Pathol Source Type: research

Serum Free Light Chain Assay and κ/λ Ratio Performance in Patients Without Monoclonal Gammopathies:  High False-Positive Rate.
CONCLUSIONS: Usual κ/λ ratio was abnormal in 36.4% of the observations in patients without evidence of monoclonal gammopathy, and an abnormal κ/λ ratio should not be used as the sole indicator for diagnosis of neoplastic proliferation of the lympho-plasmacytic system. Hypergammaglobulinemia is associated with a higher rate of false-positive abnormal κ/λ ratios. Examination of urine for monoclonal immunoglobulins may be underused, and recommendations by some to use serum free light chain assay in place of, rather than as an adjunct to, urine electrophoresis are not warranted. PMID: 27473738 [PubMed - in process] ...
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Singh G Tags: Am J Clin Pathol Source Type: research

A Review of Outcomes for Stage Ta Bladder Tumors.
CONCLUSIONS: Although greater than 50% of those with stage Ta bladder tumors have additional bladder tumors, approximately 80% appear to follow a benign course without developing invasive tumors or dying of bladder cancer. The 2004 WHO grading scheme accounts for some but not all of the prognostic information. PMID: 27473739 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Vollmer RT Tags: Am J Clin Pathol Source Type: research

Preventing Genetic Testing Order Errors With a Laboratory Utilization Management Program.
CONCLUSIONS: Clinicians without specialty training in genetics make genetic test order errors at a significantly higher rate than geneticists. A laboratory utilization management program prevents these order errors from becoming diagnostic errors and reaching the patient. PMID: 27473740 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Mathias PC, Conta JH, Konnick EQ, Sternen DL, Stasi SM, Cole BL, Astion ML, Dickerson JA Tags: Am J Clin Pathol Source Type: research

Artificial Neural Network Approach in Laboratory Test Reporting:  Learning Algorithms.
CONCLUSIONS: This is the first study based on an artificial neural network to build an experimental assessment and decision algorithm model. By integrating our trained algorithm model into a laboratory information system, it may be possible to reduce employees' workload without compromising patient safety. PMID: 27473741 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Demirci F, Akan P, Kume T, Sisman AR, Erbayraktar Z, Sevinc S Tags: Am J Clin Pathol Source Type: research

The Crossmatch/Issue Ratio:  Use of a Novel Quality Indicator and Results of an International Survey on RBC Crossmatching and Issuing Practices.
CONCLUSIONS: Electronic crossmatching is common, and the C/I ratio can be an indicator of efficiency. PMID: 27473742 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Yazer MH, Alcantara R, Beizai P, Draper NL, Harm SK, Kutner JM, Lin D, Poglod R, Rogers TS, Sørensen CH, Sprogøe U, Welbig J, Yuen J, Ziman A, Biomedical Excellence for Safer Transfusions (BEST) Collaborative Tags: Am J Clin Pathol Source Type: research

Prozone Effect in the Diagnosis of Lupus Anticoagulant for the Lupus Anticoagulant-Hypoprothrombinemia Syndrome.
CONCLUSIONS: We report for the first time a variation on this theme in a patient with a lupus anticoagulant-type antiphospholipid antibody and hypoprothrombinemia, which corrected with immunosuppression and restoration of normal prothrombin levels. PMID: 27473743 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Jin J, Zehnder JL Tags: Am J Clin Pathol Source Type: research

Successful ABO-Incompatible Renal Transplantation:  Blood Group A1B Donor Into A2B Recipient With Anti-A1 Isoagglutinins.
CONCLUSIONS: It may be safe to transplant across the A1/A2 blood group AB mismatch barrier in the setting of low titer anti-A1 isoagglutinins without the need for pretransplant desensitization even if the antibody produced reacts with anti-human globulin. PMID: 27473744 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 1, 2016 Category: Pathology Authors: Fadeyi EA, Stratta RJ, Farney AC, Pomper GJ Tags: Am J Clin Pathol Source Type: research

Process Optimization to Improve Immunosuppressant Drug Testing Turnaround Time.
CONCLUSIONS: : Adjusting ISP collection and analysis processes improved the laboratory's ability to meet physician requested result reporting time of 2:00 pm. PMID: 27453440 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 24, 2016 Category: Pathology Authors: Barakauskas VE, Bradshaw TA, Smith LD, Lehman CM, Johnson-Davis KL Tags: Am J Clin Pathol Source Type: research

Intracranial Involvement by Plasma Cell Neoplasms.
CONCLUSIONS: PCNs rarely arise in the intracranial compartment. Intracranial PCN may be the initial presentation of MM. Anecdotally, blastic morphology appears to manifest more aggressive behavior. PMID: 27453441 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 24, 2016 Category: Pathology Authors: Wilberger AC, Prayson RA Tags: Am J Clin Pathol Source Type: research

Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms:  A Potential Diagnostic Pitfall.
CONCLUSIONS: Hepatocellular differentiation markers, including albumin mRNA ISH, may be positive in ACC, but arginase 1 appears to be uniformly negative. Thus, its use may improve the accuracy in distinguishing these neoplasms from hepatocellular carcinoma. If ACC diagnosis is considered, acinar differentiation can be reliably demonstrated by trypsin/chymotrypsin. PMID: 27425386 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 17, 2016 Category: Pathology Authors: Askan G, Deshpande V, Klimstra DS, Adsay V, Sigel C, Shia J, Basturk O Tags: Am J Clin Pathol Source Type: research

Pathology of Chronic Chagas Cardiomyopathy in the United States:  A Detailed Review of 13 Cardiectomy Cases.
CONCLUSIONS: The gross and microscopic features of chronic Chagas cardiomyopathy in the United States appear similar to those reported in endemic countries. Importantly, tissue polymerase chain reaction may be useful to confirm the diagnosis. PMID: 27425387 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 17, 2016 Category: Pathology Authors: Kransdorf EP, Fishbein MC, Czer LS, Patel JK, Velleca A, Tazelaar HD, Roy RR, Steidley DE, Kobashigawa JA, Luthringer DJ Tags: Am J Clin Pathol Source Type: research

Immunophenotypes of Chronic Myelomonocytic Leukemia (CMML) Subtypes by Flow Cytometry:  A Comparison of CMML-1 vs CMML-2, Myeloproliferative vs Dysplastic, De Novo vs Therapy-Related, and CMML-Specific Cytogenetic Risk Subtypes.
CONCLUSIONS: These findings confirm heterogeneity within CMML subgroups and find no specific qualitative or quantitative findings characteristic of a subgroup. PMID: 27413139 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 13, 2016 Category: Pathology Authors: Harrington AM, Schelling LA, Ordobazari A, Olteanu H, Hosking PR, Kroft SH Tags: Am J Clin Pathol Source Type: research

Sentinel Lymph Node Frozen-Section Utilization Declines After Publication of American College of Surgeons Oncology Group Z0011 Trial Results With No Change in Subsequent Surgery for Axillary Lymph Node Dissection.
CONCLUSIONS: Our findings support reduced need for SLN FS for BCT patients post-Z0011. However, those with specific clinicopathologic features may derive greater benefit from SLN FS. PMID: 27373347 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 3, 2016 Category: Pathology Authors: Jorns JM, Kidwell KM Tags: Am J Clin Pathol Source Type: research

Vaginal Cytology Results in Follow-up of Endometrial Carcinoma After Hysterectomy.
CONCLUSIONS: Vaginal recurrences of EmCa were diagnosed in 11 (2.6%) of 420 patients with documented vaginal follow-up testing. Abnormal vaginal cytology findings directly led to vaginal biopsy diagnoses of EmCa in two of the 11 patients. Vaginal cytology is no longer a recommended routine surveillance option for detection of vaginal cuff recurrence of EmCa. PMID: 27371362 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 30, 2016 Category: Pathology Authors: Zhao C, Karunamurthy A, Jain S, Austin RM Tags: Am J Clin Pathol Source Type: research

Thymomas With Extensive Clear Cell Component:  A Clinicopathologic and Immunohistochemical Study of Nine Cases.
CONCLUSIONS: The cases herein presented highlight an unusual feature in thymoma that has more commonly been ascribed to thymic carcinoma. They also emphasize the importance of correct diagnosis to determine the appropriate treatment strategy and to accurately predict prognosis. PMID: 27371363 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 30, 2016 Category: Pathology Authors: Weissferdt A, Kalhor N, Moran CA Tags: Am J Clin Pathol Source Type: research

Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms: A Recommendation for Screening Synchronous/Metachronous Neoplasms.
CONCLUSIONS: LS diagnosis could have been missed in 31% of the study cases if only the LSAN exhibiting intact MMRP expression was screened. Accordingly, our findings support the recommendation to perform LS screening in all primary, synchronous, and metachronous intestinal and endometrial cancers if a previous tumor screened intact. PMID: 27357288 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Roth RM, Haraldsdottir S, Hampel H, Arnold CA, Frankel WL Tags: Am J Clin Pathol Source Type: research

Does Taking the Fellowship In-Service Hematopathology Examination and Performance Relate to Success on the American Board of Pathology Hematology Examination?
CONCLUSIONS: Candidates who take the spring FISHE do better on the ABP-HE than those who do not. Most fellows passed the first attempted ABP-HE regardless of FISHE performance. Whether this is due to fellows making use of the FISHE as a self-evaluation tool to help identify and then correct their knowledge deficiencies remains to be determined. PMID: 27357289 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Monaghan SA, Felgar RE, Kelly MA, Ali AM, Anastasi J, Bellara AP, Rinder HM, Sargent RL, Wagner J, Swerdlow SH, Johnson RL Tags: Am J Clin Pathol Source Type: research

Neonatal Intensive Care Unit Quality Initiative: Identifying Preanalytical Variables Contributing to Specimen Hemolysis and Measuring the Impact of Evidence-Based Practice Interventions.
CONCLUSIONS: We identified three variables contributing to hemolysis and instituted two clinical practice interventions to significantly reduce test cancellations due to hemolysis. PMID: 27357290 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Tolan NV, Kaleta EJ, Fang JL, Colby CE, Carey WA, Karon BS, Baumann NA Tags: Am J Clin Pathol Source Type: research

Evaluation of a Methotrexate Chemiluminescent Microparticle Immunoassay: Comparison to Fluorescence Polarization Immunoassay and Liquid Chromatography-Tandem Mass Spectrometry.
CONCLUSIONS: These results comparing CMIA vs FPIA and LC-MS/MS indicate that CMIA is a suitable alternative to the FPIA method. PMID: 27357291 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Bouquié R, Grégoire M, Hernando H, Azoulay C, Dailly E, Monteil-Ganière C, Pineau A, Deslandes G, Jolliet P Tags: Am J Clin Pathol Source Type: research

Transportation Cooler Interventions Reduce Plasma and RBC Product Wastage.
CONCLUSIONS: Our intervention resulted in significantly decreased plasma and RBC wastage and is broadly applicable, since out-of-temperature product wastage in procedural areas is likely a significant problem at many institutions. PMID: 27357292 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Metcalf RA, Baker SA, Goodnough LT, Shah N Tags: Am J Clin Pathol Source Type: research

Evaluation of the Sebia Capillarys 3 Tera and the Bio-Rad D-100 Systems for the Measurement of Hemoglobin A1c.
CONCLUSIONS: The Bio-Rad D-100 and the Sebia Capillarys 3 Tera instruments performed well for the determination of HbA1c in terms of quality criteria as well as for sample throughput. PMID: 27357293 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Herpol M, Lanckmans K, Van Neyghem S, Clement P, Crevits S, De Crem K, Gorus FK, Weets I Tags: Am J Clin Pathol Source Type: research

Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71.
CONCLUSIONS: Our study revealed direct pathologic evidence supporting viral entry into the central nervous system (CNS) through peripheral nerves. In addition to the major motor pathway, EV71 can also enter the CNS via peripheral sensory and autonomic pathways in retrograde axonal transport. PMID: 27357294 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 29, 2016 Category: Pathology Authors: Xing J, Liu D, Shen S, Su Z, Zhang L, Duan Y, Tong F, Liang Y, Wang H, Deng F, Hu Z, Zhou Y Tags: Am J Clin Pathol Source Type: research

Comparison of Free Light Chain Assays: Freelite and N Latex in Diagnosis, Monitoring, and Predicting Survival in Light Chain Amyloidosis.
CONCLUSIONS: Both FLC assays show good correlation in detecting the abnormal light chain subtype with discordance in absolute values and thus are not interchangeable. PMID: 27353767 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 27, 2016 Category: Pathology Authors: Mahmood S, Wassef NL, Salter SJ, Sachchithanantham S, Lane T, Foard D, Whelan CJ, Lachmann HJ, Gillmore JD, Hawkins PN, Wechalekar AD Tags: Am J Clin Pathol Source Type: research

Bone Marrow Conventional Karyotyping and Fluorescence In Situ Hybridization: Defining an Effective Utilization Strategy for Evaluation of Myelodysplastic Syndromes.
CONCLUSIONS: In the evaluation of a possible MDS, FISH rarely provides additional value when karyotype is adequate. We propose a value-based, cost-effective algorithmic approach for conventional karyotyping and FISH testing in routine MDS workup. PMID: 27353768 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 27, 2016 Category: Pathology Authors: He R, Wiktor AE, Durnick DK, Kurtin PJ, Van Dyke DL, Tefferi A, Patnaik MS, Ketterling RP, Hanson CA Tags: Am J Clin Pathol Source Type: research

Touch Preps of Products of Conception for Rule-Out Ectopic Pregnancy: A Viable Alternative to Frozen Section.
CONCLUSIONS: POC can be diagnosed by touch prep and may offer confirmation of grossly identified villi. Positive predictive value is 100%. Negative touch preps should receive further evaluation. PMID: 27317440 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 16, 2016 Category: Pathology Authors: Chen AL, Tambouret RH, Roberts DJ Tags: Am J Clin Pathol Source Type: research

Comparison of Multiparameter Flow Cytometry Immunophenotypic Analysis and Quantitative RT-PCR for the Detection of Minimal Residual Disease of Core Binding Factor Acute Myeloid Leukemia.
CONCLUSIONS: MFC and qRT-PCR are complementary tests in monitoring CBF AML MRD. PMID: 27298396 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Ouyang J, Goswami M, Peng J, Zuo Z, Daver N, Borthakur G, Tang G, Medeiros LJ, Jorgensen JL, Ravandi F, Wang SA Tags: Am J Clin Pathol Source Type: research

Performances of the H-Score for Diagnosis of Hemophagocytic Lymphohistiocytosis in Adult and Pediatric Patients.
CONCLUSIONS: The adapted HLH-2004 guidelines seem less powerful and H-score seems to be more appropriate for children, which may be due to less significantly marked biological features. For adults, H-score performances are better when determined at presentation. The cutoff value of the H-score should be adapted depending on the target population to obtain optimal specificity. PMID: 27298397 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 12, 2016 Category: Pathology Authors: Debaugnies F, Mahadeb B, Ferster A, Meuleman N, Rozen L, Demulder A, Corazza F Tags: Am J Clin Pathol Source Type: research