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Total 9957 results found since Jan 2013.
Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma
Oral Oncol. 2023 Sep 2;146:106562. doi: 10.1016/j.oraloncology.2023.106562. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCC) are associated with significant treatment-related morbidity and poor disease-free and disease-specific survival, especially in the recurrent and metastatic (R/M HNSCC) setting. Inhibition of the programmed death-1/ligand-1 (PD-1/PD-L1) immune checkpoint is accepted as a first-line treatment strategy for R/M HNSCC and has expanded into the neoadjuvant, definitive, and adjuvant settings. To understand cellular signals modulating the PD-L1 in HNSCC, we profiled a HNSCC cell-l...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jacqueline E Mann Joshua D Smith Aditi Kulkarni Susan K Foltin Erin B Scheftz Isabel R Murray Elizabeth Gensterblum-Miller Collin V Brummel Apurva Bhangale Rebecca C Hoesli J Chad Brenner Source Type: research
Systemic treatments for resectable carcinoma of the esophagus
World J Gastroenterol. 2023 Aug 14;29(30):4628-4641. doi: 10.3748/wjg.v29.i30.4628.ABSTRACTOne of the most prevalent malignancies in the world is esophageal cancer (EC). The 5-year survival rate of EC remains pitiful despite treatment advancements. Neoadjuvant chemoradiotherapy in conjunction with esophagectomy is the standard of care for patients with resectable disease. The pathological complete response rate, however, is not acceptable. A distant metastasis or a locoregional recurrence will occur in about half of the patients. To increase the clinical effectiveness of therapy, it is consequently vital to investigate cut...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma
CONCLUSION: APTw, mDIXON-Quant and DWI techniques can be usedfor quantitative identification of p53abn and p53wt EC. The multimodal MRI provides a new way for preoperative quantitative evaluation of EC molecular typing, which has certain clinical application value.PMID:37661630 | DOI:10.1177/02841851231198911
Source: Acta Radiologica - September 4, 2023 Category: Radiology Authors: Tian Shifeng Wang Yue Zhu Wen Chen Lihua Wang Nan Lin Liangjie Liu Ailian Source Type: research
Systemic treatments for resectable carcinoma of the esophagus
World J Gastroenterol. 2023 Aug 14;29(30):4628-4641. doi: 10.3748/wjg.v29.i30.4628.ABSTRACTOne of the most prevalent malignancies in the world is esophageal cancer (EC). The 5-year survival rate of EC remains pitiful despite treatment advancements. Neoadjuvant chemoradiotherapy in conjunction with esophagectomy is the standard of care for patients with resectable disease. The pathological complete response rate, however, is not acceptable. A distant metastasis or a locoregional recurrence will occur in about half of the patients. To increase the clinical effectiveness of therapy, it is consequently vital to investigate cut...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
The value of multimodal functional magnetic resonance imaging in differentiating p53abn from p53wt endometrial carcinoma
CONCLUSION: APTw, mDIXON-Quant and DWI techniques can be usedfor quantitative identification of p53abn and p53wt EC. The multimodal MRI provides a new way for preoperative quantitative evaluation of EC molecular typing, which has certain clinical application value.PMID:37661630 | DOI:10.1177/02841851231198911
Source: Acta Radiologica - September 4, 2023 Category: Radiology Authors: Tian Shifeng Wang Yue Zhu Wen Chen Lihua Wang Nan Lin Liangjie Liu Ailian Source Type: research
Systemic treatments for resectable carcinoma of the esophagus
World J Gastroenterol. 2023 Aug 14;29(30):4628-4641. doi: 10.3748/wjg.v29.i30.4628.ABSTRACTOne of the most prevalent malignancies in the world is esophageal cancer (EC). The 5-year survival rate of EC remains pitiful despite treatment advancements. Neoadjuvant chemoradiotherapy in conjunction with esophagectomy is the standard of care for patients with resectable disease. The pathological complete response rate, however, is not acceptable. A distant metastasis or a locoregional recurrence will occur in about half of the patients. To increase the clinical effectiveness of therapy, it is consequently vital to investigate cut...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
