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T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination
Cell Host Microbe. 2023 Jul 16:S1931-3128(23)00266-4. doi: 10.1016/j.chom.2023.06.015. Online ahead of print.ABSTRACTThe incidence of whooping cough due to Bordetella pertussis (BP) infections has increased recently. It is believed that the shift from whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines may be contributing to this rise. While T cells are key in controlling and preventing disease, nearly all knowledge relates to antigens in aP vaccines. A whole-genome mapping of human BP-specific CD4+ T cell responses was performed in healthy vaccinated adults and revealed unexpected broad reactivity to h...
Source: Cell Host and Microbe - July 25, 2023 Category: Microbiology Authors: Ricardo da Silva Antunes Emily Garrigan Lorenzo G Quiambao Sandeep Kumar Dhanda Daniel Marrama Luise Westernberg Eric Wang Adam Abawi Aaron Sutherland Sandra K Armstrong Timothy J Brickman John Sidney April Frazier Tod J Merkel Bjoern Peters Alessandro Se Source Type: research

Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations
Clin Microbiol Rev. 2023 Jun 12:e0016422. doi: 10.1128/cmr.00164-22. Online ahead of print.ABSTRACTBordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At...
Source: Clinical Microbiology Reviews - June 12, 2023 Category: Microbiology Authors: Beatriz Miguelena Chamorro Karelle De Luca Gokul Swaminathan St éphanie Longet Egbert Mundt St éphane Paul Source Type: research

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