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Specialty: Cancer & Oncology
Vaccination: Veterinary Vaccinations
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Total 588 results found since Jan 2013.
Leptin/lipopolysaccharide-treated dendritic cell vaccine improved cellular immune responses in an animal model of breast cancer
CONCLUSION: Compared to the Leptin-treated mDC and LPS-treated mDC vaccines, the Leptin/LPS-treated mDC vaccine was more effective in inhibiting BC development and boosting immune responses against tumor.PMID:37647347 | DOI:10.1080/08923973.2023.2253989
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Pedram Basirjafar Raziyeh Zandvakili Javad Masoumi Nahid Zainodini Zahra Taghipour Hossein Khorramdelazad Soheila Yousefi Tayyebeh Tavakoli Mahboobeh Vatanparast Sepehr Safdel Mahsa Gheitasi Fatemeh Ayoobi Bahar Naseri Abdollah Jafarzadeh Source Type: research
Plant Viruses as Adjuvants for Next-Generation Vaccines and Immunotherapy
Vaccines (Basel). 2023 Aug 16;11(8):1372. doi: 10.3390/vaccines11081372.ABSTRACTVaccines are the cornerstone of infectious disease control and prevention. The outbreak of SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel vaccines. Plant viruses and their derivatives are being used increasingly for the development of new medical and biotechnological applications, and this is reflected in a number of preclinical and clinical studies. Plant viruses have a unique combination of features (biosafety, low reactogenicity, inexpensiveness and ease of production, etc.), which determine their potentia...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Nikolai Nikitin Yuri Vasiliev Angelina Kovalenko Ekaterina Ryabchevskaya Olga Kondakova Ekaterina Evtushenko Olga Karpova Source Type: research
Current status of nano-vaccinology in veterinary medicine science
This article reviews the currently available nanovaccine technology and considers its utility for both infectious diseases and non-infectious diseases such as auto-immunity and cancer. Future research opportunities and application challenges from bench to clinical usage are also discussed.PMID:37487030 | DOI:10.1002/vms3.1221
Source: Cancer Control - July 24, 2023 Category: Cancer & Oncology Authors: Soheil Sadr Parian Poorjafari Jafroodi Mohammad Javad Haratizadeh Zahra Ghasemi Hassan Borji Ashkan Hajjafari Source Type: research
rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
CONCLUSION: The rWTC-MBTA vaccine demonstrated efficacy in multiple animal models through T-cell mediated cytotoxicity and has potential as a therapeutic option for preventing and treating tumor metastasis with minimal systemic toxicity.PMID:37434263 | DOI:10.1186/s13046-023-02744-8
Source: Clinical Breast Cancer - July 11, 2023 Category: Cancer & Oncology Authors: Juan Ye Herui Wang Rogelio Medina Samik Chakraborty Mitchell Sun Alex Valenzuela Xueyu Sang Yaping Zhang Ondrej Uher Jan Zenka Karel Pacak Zhengping Zhuang Source Type: research
The Oncolytic herpes simplex virus type-1 (HSV-1) vaccine strain VC2 causes intratumor infiltration of functionally active T cells and inhibition of tumor metastasis and pro-tumor genes VEGF and PDL1 expression in the 4T1/Balb/c mouse model of stage four breast cancer
Conclusion: These results show that VC2 therapy can improve anti-tumor response associated with a better control of tumor metastasis. improve T cell responses and reduce pro-tumor biomarker gene transcription. VC2 holds promise for further development as an oncolytic and immunotherapeutic approach to treat breast and other cancers.PMID:37388243 | PMC:PMC10303929 | DOI:10.3389/fmolb.2023.1199068
Source: Cancer Control - June 30, 2023 Category: Cancer & Oncology Authors: Rafiq Nabi Farhana Musarrat Jose Cesar Menk P Lima Ingeborg M Langohr Vladimir N Chouljenko Konstantin G Kousoulas Source Type: research
Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines
CONCLUSIONS: This study demonstrates the utility of bacterial spores for mucosal vaccination to H. pylori infection. The heat stability and robustness of Bacillus spores coupled with their existing use as probiotics make them an attractive solution for either protection against H. pylori infection or potentially for therapy and control of active infection.PMID:37314018 | DOI:10.1111/hel.12997
Source: Cancer Control - June 14, 2023 Category: Cancer & Oncology Authors: Paidamoyo M Katsande Van Duy Nguyen Thi Lan Phuong Nguyen Thi Kim Cuc Nguyen Gabrielle Mills David M D Bailey Graham Christie Huynh Anh Hong Simon M Cutting Source Type: research
Rapid construction of infectious clones for distinct Newcastle disease virus genotypes
Front Vet Sci. 2023 May 25;10:1178801. doi: 10.3389/fvets.2023.1178801. eCollection 2023.ABSTRACTThe reverse genetics system of the Newcastle disease virus (NDV) has provided investigators with a powerful approach to understand viral molecular biology and vaccine development. It has been impressively improved with modified strategies since its first report, but it still poses some challenges. Most noteworthy, the genome complexity and length made full-length error-free cDNA assembly the most challenging and time-consuming step of NDV rescue. In the present study, we report a rapid full-length NDV genome construction with o...
Source: Cancer Control - June 12, 2023 Category: Cancer & Oncology Authors: Zuhua Yu Yuhao Zhang Zedian Li Qingzhong Yu Yanyan Jia Chuan Yu Jian Chen Songbiao Chen Lei He Source Type: research
Human monkeypox virus in the shadow of the COVID-19 pandemic
CONCLUSIONS: monkeypox is a viral disease caused by the monkeypox virus (MPXV), which is primarily found in central and western Africa. The disease is transmitted from animals to humans and presents symptoms similar to those of smallpox, including fever, headache, muscle aches, and a rash. Monkeypox can lead to complications such as secondary integument infection, bronchopneumonia, sepsis, and encephalitis, as well as corneal infection that can result in blindness. There is no specific clinically proven treatment for monkeypox, and treatment is primarily supportive. However, antiviral drugs and vaccines are available for c...
Source: Cancer Control - June 3, 2023 Category: Cancer & Oncology Authors: Almu'atasim Khamees Sajeda Awadi Khayry Al-Shami Hayat Abu Alkhoun Sharaf F Al-Eitan Ahmad Malek Alsheikh Ahmad Saeed Raed M Al-Zoubi Mazhar Salim Al Zoubi Source Type: research
DNA based neoepitope vaccination induces tumor control in syngeneic mouse models
NPJ Vaccines. 2023 May 27;8(1):77. doi: 10.1038/s41541-023-00671-5.ABSTRACTRecent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer vaccines that deliver neoepitopes via various vaccine formulations have demonstrated promising preliminary results in patients and animal models. In the presented work, we assessed the ability of plasmid DNA to confer neoepitope immunogenicity and anti-tumor effect in two murine syngeneic cancer models. We demonstrated that neoepitope DNA vaccination led to anti-tumor immunity in the CT26 and B16F10 tumor models, with the long-la...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Nadia Viborg Michail Angelos Pavlidis Marina Barrio-Calvo Stine Friis Thomas Trolle Anders Bundgaard S ørensen Christian Bahne Thygesen S øren Vester Kofoed Daniela Kleine-Kohlbrecher Sine Reker Hadrup Birgitte R ønø Source Type: research
Enhanced HPV16 E6/E7 < sup > + < /sup > tumor eradication via induction of tumor-specific T cells by therapeutic vaccination with virosomes presenting synthetic long peptides
Cancer Immunol Immunother. 2023 May 24. doi: 10.1007/s00262-023-03462-y. Online ahead of print.ABSTRACTTherapeutic cancer vaccines trigger CD4 + and CD8 + T cell responses capable of established tumor eradication. Current platforms include DNA, mRNA and synthetic long peptide (SLP) vaccines, all aiming at robust T cell responses. SLPs linked to the Amplivant® adjuvant (Amplivant-SLP) have shown effective delivery to dendritic cells, resulting in improved immunogenicity in mice. We have now tested virosomes as a delivery vehicle for SLPs. Virosomes are nanoparticles made from influenza virus membranes and have been used as...
Source: Cancer Control - May 24, 2023 Category: Cancer & Oncology Authors: Toon Stegmann Anna-Sophia Wiekmeijer Kitty Kwappenberg Suzanne van Duikeren Farien Bhoelan Denzel Bemelman Thomas J M Beenakker Willem-Jan Krebber Ramon Arens Cornelis J M Melief Source Type: research
Live-attenuated Japanese encephalitis virus inhibits glioblastoma growth and elicits potent antitumor immunity
In this study, we investigated the safety of a live attenuated Japanese encephalitis vaccine strain (JEV-LAV) virus as an oncolytic virus for intracerebral injection in mice. We infected different GBM cell lines with JEV-LAV to investigate whether it had growth inhibitory effects on GBM cell lines in vitro. We used two models for evaluating the effect of JEV-LAV on GBM growth in mice. We investigated the antitumor immune mechanism of JEV-LAV through flow cytometry and immunohistochemistry. We explored the possibility of combining JEV-LAV with PD-L1 blocking therapy. This work suggested that JEV-LAV had oncolytic activity a...
Source: Cancer Control - April 28, 2023 Category: Cancer & Oncology Authors: Zhongbing Qi Jing Zhao Yuhua Li Bin Zhang Shichuan Hu Yanwei Chen Jinhu Ma Yongheng Shu Yunmeng Wang Ping Cheng Source Type: research
Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly
Nat Commun. 2023 Apr 12;14(1):2050. doi: 10.1038/s41467-023-37681-9.ABSTRACTSingapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and significantly threatens global biodiversity. In recent years, high morbidity and mortality in aquatic animals have been caused by iridovirid infections worldwide. Effective control and prevention strategies are urgently needed. Here, we present a near-atomic architecture of the SGIV capsid and identify eight types of capsid proteins. The viral inner me...
Source: Cancer Control - April 11, 2023 Category: Cancer & Oncology Authors: Zhennan Zhao Youhua Huang Congcong Liu Dongjie Zhu Shuaixin Gao Sheng Liu Ruchao Peng Ya Zhang Xiaohong Huang Jianxun Qi Catherine C L Wong Xinzheng Zhang Peiyi Wang Qiwei Qin George F Gao Source Type: research
