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Source: Stem Cells
Therapy: Stem Cell Therapy

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Total 42 results found since Jan 2013.

iPS Cell Transplantation Increases Regeneration and Functional Recovery after Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPS cell‐derived neural progenitors (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the r...
Source: Stem Cells - August 5, 2014 Category: Stem Cells Authors: Monica Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Original Research Source Type: research

iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats
Abstract Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the benefits of iPSC transplantation in neonates are relatively unknown. We hypothesized that transplanted iPSC‐derived neural progenitor cells (iPSC‐NPCs) would increase regeneration after stroke. Mouse pluripotent iPSCs were differentiated into neural progenitors using a retinoic acid protocol. Differentiated neural cells were characterized by using multiple criteria and assessments. Ischemic stroke was induced in postnatal day 7 (P7) rats by occluding the ...
Source: Stem Cells - November 26, 2014 Category: Stem Cells Authors: Monica J. Chau, Todd C. Deveau, Mingke Song, Xiaohuan Gu, Dongdong Chen, Ling Wei Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Towards BBB Repair in Ischemic Stroke Rats
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Source: Stem Cells - January 30, 2017 Category: Stem Cells Authors: Svitlana Garbuzova ‐Davis, Edward Haller, Roger Lin, Cesario V. Borlongan Tags: Regenerative Medicine Source Type: research

Human placenta mesenchymal stem cell protection in ischemic stroke is Angiotensin converting enzyme ‐2 (ACE‐2) and masR receptor dependent
In this study we demonstrated that hPMSC-derived ACE2 is required to protect against progressive loss of cerebral blood perfusion following ischemic stroke. This effect is also mediated through vascular endothelial Mas receptor but not AT2 receptor. Consequently, the results of our experimental stroke studies with human derived stem cells describes new paracrine function of hPMSC in which ACE2 and Mas receptor are critical, therefore, providing a novel therapeutic strategy for stroke in near future.
Source: Stem Cells - June 15, 2021 Category: Stem Cells Authors: Mansoureh Barzegar, Shantel Vital, Karen Y. Stokes, Yuping Wang, J. Winny Yun, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander Tags: Regenerative Medicine Source Type: research

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen
Abstract Stem cell therapy modulates not only the local microenvironment of the brain but also the systemic immune responses. We explored the impact of human multipotent adult progenitor cells (MAPC) modulating splenic activation and peripheral immune responses after ischemic stroke. Hundred twenty‐six Long‐Evans adult male rats underwent middle cerebral artery occlusion. Twenty‐four hours later, they received IV MAPC or saline treatment. At 3 days after infusion, RNA was isolated from the injured cortex and spleen for microarray analysis. Spleen mass, splenocyte phenotype, and releasing cytokines were measured. Seru...
Source: Stem Cells - March 5, 2017 Category: Stem Cells Authors: Bing Yang, Jason A. Hamilton, Krystal S. Valenzuela, Annelies Bogaerts, XiaoPei Xi, Jaroslaw Aronowski, Robert W. Mays, Sean I. Savitz Tags: Regenerative Medicine Source Type: research

MiR‐126 Contributes to Human Umbilical Cord Blood Cell Induced Neurorestorative Effects after Stroke in Type‐2 Diabetic Mice
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Source: Stem Cells - August 24, 2015 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Transplantation of unique subpopulation of fibroblasts, Muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation
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Source: Stem Cells - September 21, 2015 Category: Stem Cells Authors: Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Regenerative Medicine Source Type: research

MiR‐126 Contributes to Human Umbilical Cord Blood Cell‐Induced Neurorestorative Effects After Stroke in Type‐2 Diabetic Mice
Abstract Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white‐matter injury than stroke in non‐DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type‐2 diabetes (T2DM). db/db‐T2DM and db/+‐non‐DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non‐DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve‐HUCBC; (d) T2DM + miR‐126−/−HUCBC. Functional evaluation, vascular and white‐matter cha...
Source: Stem Cells - January 13, 2016 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme ‐2 and masR receptor‐dependent
Angiotensin converting enzyme-2 (ACE-2) contributes to human placenta mesenchymal stem cell (hPMSC)-induced protection against ischemic injury through MasR pathway. AbstractThromboembolic stroke remains a major cause of neurological disability and death. Current stroke treatments (aspirin, tissue plasminogen activator) are significantly limited by timing and risks for hemorrhage which have driven researchers to explore other approaches. Stem cell-based therapy appears to be an effective option for ischemic stroke. Besides trans-differentiation into neural cells, stem cells also provide acute protection via paracrine signal...
Source: Stem Cells - June 22, 2021 Category: Stem Cells Authors: Mansoureh Barzegar, Shantel Vital, Karen Y. Stokes, Yuping Wang, Jungmi Winny Yun, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander Tags: Regenerative Medicine Source Type: research

PDGFR‐β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke
Abstract The neuroprotective agents and induction of endogenous neurogenesis remain to be the urgent issues to be established for the care of cerebral stroke. Platelet‐derived growth factor receptor beta (PDGFR‐β) is mainly expressed in neural stem/progenitor cells (NSPCs), neurons and vascular pericytes of the brain; however, the role in pathological neurogenesis remains elusive. To this end, we examined the role of PDGFR‐β in the migration and proliferation of NSPCs after stroke. A transient middle cerebral‐arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb‐gene inactivation, inclu...
Source: Stem Cells - October 4, 2015 Category: Stem Cells Authors: Hikari Sato, Yoko Ishii, Seiji Yamamoto, Erika Azuma, Yoriko Takahashi, Takeru Hamashima, Akihiro Umezawa, Hisashi Mori, Satoshi Kuroda, Shunro Endo, Masakiyo Sasahara Tags: Tissue‐Specific Stem Cells Source Type: research

Cell therapies for stroke and traumatic brain injury: Targeting microglia
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Source: Stem Cells - January 1, 2016 Category: Stem Cells Authors: Sean I. Savitz, Charles S. Cox Tags: Regenerative Medicine Source Type: research

Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial
Diffusion tensor tractography using serial multimodel magnetic resonance imaging contrast in a representation patient who received autologous bone marrow ‐derived mononuclear cells after acute ischemic stroke. AbstractCellular therapy is a promising investigational modality to enhance poststroke recovery. We conducted a single ‐arm, phase I clinical trial to determine the safety and feasibility of intravenous (IV) administration of autologous bone marrow mononuclear cells (MNCs) after acute ischemic stroke (AIS). Patients with moderate severity of AIS underwent bone marrow harvest followed by IV reinfusion of MNCs with...
Source: Stem Cells - September 16, 2019 Category: Stem Cells Authors: Farhaan S. Vahidy, Muhammad E. Haque, Mohammad H. Rahbar, Hongjian Zhu, Paul Rowan, Imoigele P. Aisiku, Dean A. Lee, Harinder S. Juneja, Susan Alderman, Andrew D. Barreto, Jose I. Suarez, Arvind Bambhroliya, Khader M. Hasan, Mallikarjuna Rao Tags: Translational and Clinical Research Source Type: research

Long noncoding RNA mediates stroke ‐induced neurogenesis
In this study, we found that H19 was the most highly upregulated lncRNA in neural stem cells (NSCs) of the subventricular zone (SVZ) of rats subjected to focal cerebral ischemia. Deletion o f H19 suppressed cell proliferation, promoted cell death, and blocked NSC differentiation. RNA sequencing analysis revealed that genes deregulated by H19 knockdown were those that are involved in transcription, apoptosis, proliferation, cell cycle, and response to hypoxia. H19 knockdown significantl y increased the transcription of cell cycle‐related genes including p27, whereas overexpression of H19 substantially reduced expression o...
Source: Stem Cells - May 1, 2020 Category: Stem Cells Authors: Baoyan Fan, Wanlong Pan, Xinli Wang, Min Wei, Annie He, Anna Zhao, Michael Chopp, Zheng Gang Zhang, Xian Shuang Liu Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research