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Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
CONCLUSION: Compared with ICS/LABA, dual LAMA/LABA or triple therapy increases cardiovascular risk in patients with COPD. This should be considered in the context of the incremental benefits of these therapies on symptoms and exacerbation rates in patients with COPD especially in those with a MACE risk of >1%/year.PMID:36137586 | DOI:10.1183/13993003.00302-2022
Source: Respiratory Care - September 22, 2022 Category: Respiratory Medicine Authors: Mingjin Yang Yishi Li Youfan Jiang Shuliang Guo Jian-Qing He Don D Sin Source Type: research

The effects of medications for treating COPD and allied conditions on stroke: a population-based cohort study
This study aimed to investigate the clinical factors of stroke risk in COPD and allied conditions patients and associations between medications for treating COPD and allied conditions. The population-based study cohort comprised 24,173 patients diagnosed with COPD and allied conditions between 2000 and 2013, and 24,170 selected matched patients without COPD comprised the comparison cohort from a nationwide database. Cox-proportional hazard regression was performed to determine the impact of medical therapies, comorbidities, and other clinical factors on stroke risk. Of the 48,343 included patients, 1394 (2.9%) experienced ...
Source: Respiratory Care - January 18, 2022 Category: Respiratory Medicine Authors: Ai-Ling Shen Hsiu-Li Lin Hsiu-Chen Lin Jane Chen-Jui Chao Chien-Yeh Hsu Chung-Yu Chen Source Type: research