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Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research

Ultra-early Institution of Statin Treatment is Associated with Improved Outcomes Among Acute Ischemic Stroke Patients Receiving Thrombolytic Treatment (P5.150)
Conclusions:Ultra-early institution of statin treatment in acute ischemic stroke patients treated with IV rt-PA with or without endovascular treatment was associated with improved outcome at both 3 and 12 monthsDisclosure: Dr. Saleem has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Saleem, M., Qureshi, A. Tags: Clinical Neuro-rehabilitation Source Type: research

High Rate of Stenosis Progression Identified with Routine Carotid Doppler Surveillance (P5.284)
Conclusions:Among this prospective cohort of asymptomatic ≥50% carotid stenosis subjects followed with carotid Doppler imaging, high rates of carotid stenosis progression occurred despite contemporary intensive medical management, and significant TIA/stroke rates were also noted, especially among those with ≥80% stenosis. These results support further study of routine carotid Doppler surveillance in management of asymptomatic carotid stenosis.Study Supported by:Grants from the American Heart Association (15GRNT25270010), NIH (1 U54GM104938) and the VA Clinical Science Research & Development Service (CX000340)Disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kirkpatrick, A., Stoner, J., Tafur, A., Elias, A., Prodan, C. Tags: SubAcute Interventional Therapies in Cerebrovascular Disease Source Type: research

Left ventricular wall motion abnormalities are associated with stroke recurrence
Conclusions: This study suggests that LVWMA, even when unassociated with high-risk cardioembolic sources, could be an independent predictor for stroke recurrence in patients with ischemic stroke.
Source: Neurology - February 5, 2017 Category: Neurology Authors: Choi, J.-Y., Cha, J., Jung, J.-M., Seo, W.-K., Oh, K., Cho, K.-H., Yu, S. Tags: Cardiac, Embolism, Infarction ARTICLE Source Type: research

Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage
Conclusions: Longitudinal lipid levels differ between ICH cases and non-ICH controls, most notably for a decline in serum TC and LDL levels within 6 months preceding primary ICH, independent of statin or alcohol use. These changes in serum TC and LDL trends suggest a biological pathway that precipitates ICH occurrence. Further studies are needed to replicate these results and characterize rate of change in serum lipids as a potential biomarker of impending acute cerebral injury.
Source: Neurology - May 29, 2016 Category: Neurology Authors: Phuah, C.-L., Raffeld, M. R., Ayres, A. M., Viswanathan, A., Greenberg, S. M., Biffi, A., Rosand, J., Anderson, C. D. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Statins and poststroke intracerebral hemorrhage: Concern but increasing reassurance
Post hoc analyses of data from randomized controlled trials can generate useful hypotheses, but need to be considered exploratory. When conducted, such evaluations should adhere to specified criteria and test for a treatment by subgroup interaction for the trial's primary endpoint.1 The best way to proceed if unexpected but potentially important outcomes occur is less clear. Concern that treatment with HMG-CoA reductase inhibitors (i.e., statins) might increase the risk of poststroke intracerebral hemorrhage (ICH) arose from an unanticipated observation in the Stroke Prevention with Aggressive Reduction in Cholesterol Leve...
Source: Neurology - April 24, 2016 Category: Neurology Authors: Goldstein, L. B., Nederkoorn, P. J. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage EDITORIALS Source Type: research

Atorvastatin Treatment Is Associated with Increased BDNF Level and Improved Functional Recovery after Atherothrombotic Stroke (S31.007)
Conclusions: Our results demonstrated that atorvastatin treatment was associated with increased BDNF level and improved functional recovery after atherothrombotic stroke. This study indicates that atorvastatin-related elevation in BDNF may promote functional recovery in stroke patients.Disclosure: Dr. Zhang has nothing to disclose. Dr. Mu has nothing to disclose. Dr. Gao has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zhang, J., Mu, X., Gao, Z., Huang, Y. Tags: Stroke Risk, Outcomes, and Complications Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (S4.002)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Recanalization Therapy of Acute Internal Carotid Artery Occlusion: Comparison of Carotid Endarterectomy and Endovascular Treatment (P6.068)
CONCLUSIONS: Data from this national multicenter registry showed that both CEA and EVT (including bridging therapy) represent safe and effective recanalization methods of acute ICAo. Better clinical outcome was observed in patients without intracranial occlusion and with achieved recanalization. Study Supported by: Internal Grant Agency of Ministry of Health of the Czech Republic grants NT/11046-6/2010, NT/13498-4/2012.Disclosure: Dr. Herzig has nothing to disclose. Dr. Roubec has nothing to disclose. Dr. Skoloudik has nothing to disclose. Dr. Kuliha has nothing to disclose. Dr. Sanak received personal compensation for act...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Herzig, R., Roubec, M., Skoloudik, D., Kuliha, M., Sanak, D., Waishaupt, J., Vitkova, E., Blejcharova, K., Krajickova, D., Tomek, A., Krajina, A., Prochazka, V., Kocher, M., Charvat, F., Fadrna, T., Zapletalova, J., Valis, M. Tags: Cerebrovascular Disease: Miscellaneous Interventions Source Type: research

Hepatic S1P Deficiency Reduces Atheroma Formation in LDLR-/- Mice (P5.227)
Conclusion: Hepatic S1P is a physiological modulator of plasma lipid metabolism through its regulation of VLDL secretion, especially when LDLR function is compromised. Utilizing genetic models, our data demonstrate the protective effect of hepatic S1P inhibition for reducing atheroma formation. Thus, S1P inhibitors could be potentially used to treat atherosclerosis and prevent stroke.Disclosure: Dr. Jin has nothing to disclose. Dr. Basu has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jin, W., Basu, D. Tags: Cerebrovascular Disease: Animal Models and In Vitro Models Source Type: research

COLADAS: Caribbean Origin Latin Americans Disparities in Acute Stroke (I5.006)
Conclusions: Our study reveals intrinsic sex differences that may imply under treatment. Understanding the reasons underlying these "sex-gaps" is critical. Study Supported By: Award Number Grants 5S21MD000242 and 5S21MD000138, from the National Center for Minority Health and Health Disparities, National Institutes of Health (NCMHD-NIH).Disclosure: Dr. Teron Molina has nothing to disclose. Dr. Rodríguez Centeno has nothing to disclose. Dr. Santiago has nothing to disclose. Dr. López Valentín has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Teron Molina, I., Rodriguez Centeno, A., Santiago, F., Lopez Valentin, M. Tags: Sex-related Factors in Neurological Disease Data Blitz Presentations Source Type: research

White Matter Hyperintensity in Patients with Mild Traumatic Brain Injury Correlates with Higher Coated-Platelet Levels (P3.323)
Conclusions: These preliminary results suggest that increased platelet procoagulant potential and age are significant predictors for the presence of WMH in mTBI, many years after the injury. Additional studies aimed at determining the long-term impact of these findings is warranted.Disclosure: Dr. Prodan has received research support from the Veterans Affairs Office. Dr. Vincent has nothing to disclose. Dr. Guthery has nothing to disclose. Dr. Mathews has nothing to disclose. Dr. Sadler has nothing to disclose. Dr. Dale has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Prodan, C., Vincent, A., Guthery, L., Mathews, E., Sadler, D., Dale, G. Tags: Neuro Trauma and Sports Neurology Source Type: research

Aggressive Medical Management for ICAD: A Comparison to the SAMMPRIS Trial (P1.174)
Conclusions:In a single center observational cohort study, we found that AMM in symptomatic ICAD yielded higher rates of recurrent stroke at 30 days when compared to the SAMMPRIS trial. This indicates that it may be more difficult to replicate the AMM and lifestyle modifications that were implemented in the SAMMPRIS trial and warrants further investigation.Disclosure: Dr. Sangha has nothing to disclose. Dr. Ansari has nothing to disclose. Dr. Bernstein has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals, Inc., and Pfizer Inc. as a speaker/advisory board member. Dr. Corado has nothing...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sangha, R., Ansari, S., Bernstein, R., Corado, C., Curran, Y., Ruff, I., Prabhakaran, S. Tags: Cerebrovascular Disease: Risk Factors and Prevention Source Type: research

10-Second heart rate variability and cognitive function in old age
Conclusions: Participants with lower 10-second HRV have worse performance in reaction time and processing speed and experience steeper decline in their processing speed, independent of medications, cardiovascular risk factors, and comorbidities.
Source: Neurology - March 21, 2016 Category: Neurology Authors: Mahinrad, S., Jukema, J. W., van Heemst, D., Macfarlane, P. W., Clark, E. N., de Craen, A. J. M., Sabayan, B. Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, All epidemiology ARTICLE Source Type: research

Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

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