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Subarachnoid pharmacodialysis for central nervous system disorders
Abstract: We postulate that alternating use of microcontroller-regulated delivery and drain pumps connected to one or more sealed subarachnoid fluid exchange ports can maintain localized bi-directional molecular fluxes across pia mater covering multiple diseased areas of the cerebral cortex or spinal cord. This system enables local irrigation with drugs and drainage of endogenous neurotoxic molecules normalizing regional neurochemistry and restoring physiological function. Viewing the pia mater as an endogenous dialysis membrane, testing this hypothesis requires demonstrating: (a) benefits of removing neurotoxic molecules ...
Source: Medical Hypotheses - November 5, 2012 Category: Biomedical Science Authors: John G. Kral, Nandor Ludvig Tags: Articles Source Type: research
