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Associations of Tissue and Soluble LOX-1 with Human Abdominal Aortic Aneurysm
Conclusions In AAA, sLOX-1 was differently affected by age, cardiometabolic diseases, and corresponding medical therapies. Comparison with nonatherosclerotic disease would be beneficial to further elucidate the diagnostic potential of sLOX-1, although it was not useful for risk stratification. Aneurysmal LOX-1 mRNA expression was increased and positively associated with smooth muscle cells and collagen content, suggesting that LOX-1 is eventually not deleterious in human AAA and could counteract AAA rupture.PMID:37421287 | DOI:10.1161/JAHA.122.027537
Source: Atherosclerosis - July 8, 2023 Category: Cardiology Authors: Anja Hofmann Yazan Khorzom Anna Klimova Steffen Wolk Albert Busch Pamela Sabarstinski Margarete M üglich Dmitry Egorov Irakli Kopaliani David M Poitz Marvin Kapalla Bianca Hamann Frieda Frank Christian J änichen Coy Brunssen Henning Morawietz Christian Source Type: research

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development or pla...
Source: Atherosclerosis - March 23, 2023 Category: Cardiology Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research

Arterial Atherosclerosis: Vascular Surgery Interventions
Am Fam Physician. 2022 Jan 1;105(1):65-72.ABSTRACTAtherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Renal artery stenosis may affect up to 5% of people with isolated hypertension and up to 40% of people with other atherosclerotic diseases. All patients with atherosclerotic vascular disease should receive a comprehensive program of guidelin...
Source: Atherosclerosis - January 14, 2022 Category: Cardiology Authors: Jonathon M Firnhaber C S Powell Source Type: research

Cerebral embolism in the perioperative period in patients post invasive treatment of carotid artery stenosis. Does invasive treatment prevent cerebral embolism?
CONCLUSIONS: 1. Microembolic signals in the middle cerebral artery detected with the use of transcranial ultrasound examination in the early period after carotid revascularization of the internal carotid artery are usually asymptomatic. 2. Cerebral embolism in the early period after carotid revascularization is more frequently found inpatients with symptomatic carotid artery stenosis subjected to a repair procedure. 3. The clinical significance of cerebral emboli found after carotid revascularization requires further research. PMID: 24846363 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - May 20, 2014 Category: Cardiology Authors: Lasek-Bal A, Urbanek T, Puz P, Ziaja D, Ziaja K Tags: Kardiol Pol Source Type: research