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SARS-CoV-2 infection and SLE: endothelial dysfunction, atherosclerosis, and thrombosis
We present systemic lupus erythematosus (SLE) as a model rheumatic disease with endothelial dysfunction and discuss its mechanisms, factors that influence the early onset and rapid progression of atherosclerosis, and the increased risk of thromboembolic events. We focus on established methods to improve endothelium function, including statins, antiplatelet, and antithrombotic therapy. Hypercoagulable and hypofibrinolitic states and a hyperinflammatory response characterize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathogenic mechanisms are typical for an acute phase of Covid-19 post-Co...
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Wojciech P łazak Leszek Drabik Source Type: research

Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy
Methodist Debakey Cardiovasc J. 2021 Dec 15;17(5):53-62. doi: 10.14797/mdcvj.1044. eCollection 2021.ABSTRACTSARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disease. Accumulating evidence indicates that a profound disturbance of endothelial homeostasis contributes to these conditions. Furthermore, the pulmonary infiltration and edema, and later pulmonary fibrosis, in patients with ...
Source: Methodist DeBakey Cardiovascular Journal - January 7, 2022 Category: Cardiology Authors: John P Cooke John H Connor Abhishek Jain Source Type: research

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