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Specialty: Cardiology
Management: National Institutes of Health (NIH)
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Total 40 results found since Jan 2013.
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Effects of adjuvant berberine therapy on acute ischemic stroke: A meta-analysis
Phytother Res. 2023 Jul 8. doi: 10.1002/ptr.7920. Online ahead of print.ABSTRACTWe conducted a meta-analysis to evaluate the clinical efficacy of berberine (BBR) in treating acute ischemic stroke (AIS), explore its anti-inflammatory effects, and assess its potential applications for AIS patients. We comprehensively searched nine databases from inception until July 1, 2022, to identify clinical trials investigating the use of BBR in treating AIS. We performed statistical analyses using RevMan5.4 software and focused on primary outcomes such as inflammatory markers as well as secondary outcomes including immune system indica...
Source: Atherosclerosis - July 8, 2023 Category: Cardiology Authors: Dan Luo Baili Yu Shoukai Sun Bonan Chen Harsh Vivek Harkare Longlong Wang Jie Pan Bin Huang Yang Song Tianhong Ma Shihua Shi Source Type: research
Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury
Ann Clin Transl Neurol. 2023 Jun 23. doi: 10.1002/acn3.51837. Online ahead of print.ABSTRACTOBJECTIVE: Accumulating studies have shown that circulating circular RNAs (circRNAs) represent novel biomarkers for many human diseases. We investigated whether plasma circPTP4A2 and circTLK2 levels are associated with stroke severity, infarct volume, stroke etiology, and functional outcome in acute ischemic stroke (AIS) patients.METHODS: We applied quantitative real-time PCR (qPCR) to measure plasma circPTP4A2 and circTLK2 levels of 236 AIS patients within 72 h of symptoms onset and 136 healthy controls. We further assessed the Nat...
Source: Atherosclerosis - June 23, 2023 Category: Cardiology Authors: Xingzhi Wang Shenyang Zhang Zuohui Zhang Jie Zu Hongjuan Shi Lu Yu Bingchen Lv Likun Cui Wenqi Mao Di Wu Guiyun Cui Source Type: research
Blood viscosity associated with stroke mechanism and early neurological deterioration in middle cerebral artery atherosclerosis
Sci Rep. 2023 Jun 9;13(1):9384. doi: 10.1038/s41598-023-36633-z.ABSTRACTBlood viscosity may affect the mechanisms of stroke and early neurological deterioration (END). We aimed to investigate the relationship between blood viscosity, stroke mechanisms, and END in patients with middle cerebral artery (MCA) infarction. Patients with symptomatic MCA atherosclerosis (≥ 50% stenosis) were recruited. Blood viscosity was compared across patients with different mechanisms of symptomatic MCA disease: in situ thrombo-occlusion (sMCA-IST), artery-to-artery embolism (sMCA-AAE), and local branch occlusion (sMCA-LBO). END was defined ...
Source: Atherosclerosis - June 9, 2023 Category: Cardiology Authors: Ho Geol Woo Hyug-Gi Kim Kyung Mi Lee Sang Hee Ha HangJin Jo Sung Hyuk Heo Dae-Il Chang Bum Joon Kim Source Type: research
Clinical significance of CT angiographic assessment of collateral circulation combined with serum NLRP1 levels in ischemic stroke patients
This study showed that the serum NLRP1 levels were remarkably decreased in ischemic stroke patients. In addition, the serum NLRP1 levels and ASITN/SIR grade could predict the prognosis of ischemic stroke patients.PMID:37000063 | DOI:10.1097/MD.0000000000033433
Source: Atherosclerosis - March 31, 2023 Category: Cardiology Authors: Chong Tao Yu Wang Shiyin Xiao Source Type: research
Predictive Role of hsCRP in Recurrent Stroke Differed According to Severity of Cerebrovascular Disease: Analysis from a Prospective Cohort Study
J Clin Med. 2023 Feb 20;12(4):1676. doi: 10.3390/jcm12041676.ABSTRACTElevated levels of high-sensitivity C-reactive protein (hsCRP) were associated with an increased risk of recurrent stroke. However, it is still unknown whether the predictive value of hsCRP differed according to the severity of cerebrovascular disease. We used the cohort of the prospective multicenter cohort study of the Third China National Stroke Registry (CNSR-III), in which 10,765 consecutive patients with acute ischemic stroke or transient ischemic attack (TIA) had hsCRP levels measured. Patients were classified into minor stroke, or TIA, and non-min...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Jiejie Li Yuesong Pan Mengxing Wang Xia Meng Jinxi Lin Zixiao Li Hao Li Yilong Wang Xingquan Zhao Liping Liu Yongjun Wang Source Type: research
Treatment of progressive ischemic stroke with low ‑dose eptifibatide: A retrospective case‑control study
Exp Ther Med. 2022 Nov 22;25(1):22. doi: 10.3892/etm.2022.11721. eCollection 2023 Jan.ABSTRACTProgressive ischemic stroke (PIS) is a therapeutic challenge in clinical practice. The present retrospective study aimed to investigate the safety and effectiveness of eptifibatide in the treatment of PIS. The present study enrolled patients with PIS admitted to Xiangtan Central Hospital (Xiangtan, China) between March 2020 and March 2021 with National Institutes of Health Stroke Scale (NIHSS) progression scores of ≥2 points during the initial 72 h. Patients were then divided into two groups according to their different anti-pla...
Source: Atherosclerosis - December 23, 2022 Category: Cardiology Authors: Long Luo Jinsheng Lin Ye Deng Zhigang Li Ying Yuan Wen Zhang Source Type: research
The acute-to-chronic glycemic ratio correlates with the severity of illness at admission in patients with diabetes experiencing acute ischemic stroke
Front Neurol. 2022 Nov 7;13:938612. doi: 10.3389/fneur.2022.938612. eCollection 2022.ABSTRACTAcute hyperglycemia is a powerful indicator of the severity of acute ischemic stroke (AIS); however, the relationship between these two factors is not very clear in patients with diabetes. We aimed to retrospectively evaluate data from 335 consecutive patients who experienced AIS from November 2015 to November 2016 to investigate whether a comprehensive assessment of blood glucose levels is a more valuable indicator of the severity of AIS or the presence of acute hyperglycemia in patients with diabetes. We collected demographic dat...
Source: Atherosclerosis - November 24, 2022 Category: Cardiology Authors: Chao Liu Xu-Ping Zhu Xiao-Wei Zhu Yan-Min Jiang Guang-Jun Xi Lan Xu Source Type: research
Factors Predicting Misidentification of Acute Ischemic Stroke and Large Vessel Occlusion by Paramedics
The emergence of thrombectomy for large vessel occlusions has increased the importance of accurate prehospital identification and triage of acute ischemic stroke (AIS). Despite available clinical scores, prehospital identification is suboptimal. Our objective was to improve the sensitivity of prehospital AIS identification by combining dispatch information with paramedic impression. We performed a retrospective cohort review of emergency medical services and hospital records of all patients for whom a stroke alert was activated in 1 urban, academic emergency department from January 1, 2018, to December 31, 2019. Using admi...
Source: Critical Pathways in Cardiology - November 24, 2022 Category: Cardiology Tags: Original Study Source Type: research
Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack
This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% a...
Source: Atherosclerosis - August 23, 2022 Category: Cardiology Authors: Keon-Joo Lee Dong Woo Shin Hong-Kyun Park Beom Joon Kim Jong-Moo Park Kyusik Kang Tai Hwan Park Kyung Bok Lee Keun-Sik Hong Yong-Jin Cho Dong-Eog Kim Wi-Sun Ryu Byung-Chul Lee Kyung-Ho Yu Mi-Sun Oh Soo Joo Lee Jae Guk Kim Jun Lee Jae-Kwan Cha Dae-Hyun Kim Source Type: research
