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Specialty: Cardiology
Source: International Journal of Cardiology
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Total 880 results found since Jan 2013.
Left atrial microvascular endothelial dysfunction, myocardial inflammation and fibrosis after selective insular cortex ischemic stroke
Insular cortex (IC) ischemic strokes are associated with increased risk of cardiac arrhythmias. We have previously hypothesized that the anatomical substrate for post-stroke neurogenic arrhythmias comprises stroke-induced left atrium (LA) coronary microvascular endothelial dysfunction (CMED), and myocardial inflammatory infiltration (MII) leading to myocardial fibrosis. We investigated whether selectively induced IC ischemic stroke in rats results in histopathological changes in the LA.
Source: International Journal of Cardiology - June 1, 2019 Category: Cardiology Authors: Brittany Balint, Victoria Jaremek, Victoria Thorburn, Shawn N. Whitehead, Luciano A. Sposato Source Type: research
Stroke risk assessment in atrial fibrillation: Beyond atrial rhythm
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, and is responsible for at least 20% of all strokes. Moreover, strokes associated to AF are largely avoidable, as the use of anti-vitamin K drugs can prevent>65% of all strokes, and direct oral anticoagulants con reduce the rate of stroke by a further 19% [1].
Source: International Journal of Cardiology - May 22, 2019 Category: Cardiology Authors: Giovanni Luca Botto, Francesco Maria Brasca Tags: Editorial Source Type: research
High prevalence of inherited thrombophilia and antiphospholipid syndrome in myocardial infarction with non-obstructive coronary arteries: Comparison with cryptogenic stroke
A role of thrombophilia in myocardial infarction with non-obstructive coronary arteries (MINOCA) is unclear. We investigated thrombophilic factors in MINOCA patients versus those following cryptogenic stroke (CS), a well-established indication for thrombophilia screening.
Source: International Journal of Cardiology - May 17, 2019 Category: Cardiology Authors: Konrad Stepien, Karol Nowak, Ewa Wypasek, Jaroslaw Zalewski, Anetta Undas Source Type: research
Cheyne-Stokes respiration in heart failure: Only provocative pathophysiology will provide new insights!
Cheyne-Stokes respiration (CSR) - a type of periodic breathing characterised by periods of hyperventilation (crescendo-decrescendo pattern) that alternate with central apneas - is highly prevalent in patients with systolic heart failure (HF) [1 –3]. CSR has been hypothesised to further increase sympathetic drive and stroke volume, thus exerting detrimental effects if left untreated [4]. At least, this is what most people thought prior to publication of the SERVE-HF trial in 2015 [5]. This trial enrolled more than 1300 patients with systo lic HF and central sleep apnea who were randomly assigned to adaptive servo-ventilat...
Source: International Journal of Cardiology - May 2, 2019 Category: Cardiology Authors: Jens Spiesshoefer Tags: Editorial Source Type: research
Real-world persistence with direct oral anticoagulants (DOACs) in na ïve patients with non-valvular atrial fibrillation
Anticoagulation therapy is central for the management of stroke in patients with non-valvular atrial fibrillation (NVAF). Persistence with oral anticoagulation is essential to prevent thromboembolic complications.
Source: International Journal of Cardiology - April 18, 2019 Category: Cardiology Authors: Eliana Ferroni, Nicola Gennaro, Giorgio Costa, Ugo Fedeli, Gentian Denas, Vittorio Pengo, Maria Chiara Corti Source Type: research
Atrial fibrillation case finding in over 65 s with cardiovascular risk factors – Results of initial Scottish clinical experience
Atrial fibrillation (AF) is a major preventable risk factor for stroke and may be silent in elderly individuals who are at especially high risk. This paper describes the first phase of implementation of a clinical AF detection programme in a community setting. Objectives were (i) to determine the feasibility of using a handheld ECG recording system for AF detection among individuals aged 65 years or more, who have cardiovascular risk factors. (ii) to estimate the yield of previously undiagnosed atrial fibrillation cases, and the proportion of these who would be suitable for oral anticoagulation.
Source: International Journal of Cardiology - March 28, 2019 Category: Cardiology Authors: Neil R. Grubb, Douglas Elder, Paul Broadhurst, Anne Reoch, Emma Tassie, Neilson Aileen Source Type: research
Authors' reply to Preoperative CT scan for Postoperative Stroke Prediction in Minimally Invasive Mitral Valve Surgery: Statistical Concern for Clinical Factors in Regression analyses
The letter by Lou et al. is based on a misinterpretation of our paper.
Source: International Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Jeremy R. Leonard, Antonino Di Franco, Mario Gaudino Tags: Letter to the Editor Source Type: research
Preoperative CT scan for postoperative stroke prediction in minimally invasive mitral valve surgery: Statistical concern for clinical factors in regression analyses
We read with great interest the paper by Leonard et al. [1] online published in IJC in Dec 12, 2018. They included 57 articles (19 CT versus 38 non-CT) with a total of 13,731 patients in the pooled analysis, and tried to identify the potential influential clinical factors of stroke occurrence following minimally invasive mitral valve surgery (MIMVS). Finally, 10 clinical factors (age, female gender, CAD, hypertension, non-CT screening, etc.) have been found to be with significant importance for the incidence of stroke using univariate mete-regression analyses.
Source: International Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Baohui Lou, Chenghui Zhou Tags: Letter to the editor Source Type: research
Psoriasis and acute coronary syndrome risk
Psoriasis is associated with increased mortality caused primarily by cardiovascular diseases (CVD). Several systematic reviews and meta-analyses reported an association between psoriasis and CVD [1,2], highlighting an increased risk of CVD especially in those patients with severe psoriasis. Both mild and severe psoriasis are associated with an increased risk of myocardial infarction (MI) and stroke, while severe psoriasis is also associated with an increased risk of cardiovascular mortality [3].
Source: International Journal of Cardiology - February 22, 2019 Category: Cardiology Authors: Alexandros Sachinidis, Dragana Nikolic, Manfredi Rizzo, Domenico Cianflone Tags: Editorial Source Type: research
The reduction of NDUFC2 expression is associated with mitochondrial impairment in circulating mononuclear cells of patients with acute coronary syndrome
Deficiency of NADH dehydrogenase [ubiquinone], the mitochondrial complex I, represents an emerging mechanism of cardiovascular diseases. Ndufc2, a subunit of mitochondrial complex I, is involved in stroke development. We aimed to gain some insights on the role of Ndufc2 into acute coronary syndrome (ACS) through the assessment of its gene expression, along with that of anti-oxidant proteins and of mitochondrial function parameters, in circulating mononuclear cells (PBMCs) of ACS versus stable angina (SA) patients.
Source: International Journal of Cardiology - February 14, 2019 Category: Cardiology Authors: Salvatore Raffa, Xiao Lan Diana Chin, Rosita Stanzione, Maurizio Forte, Franca Bianchi, Maria Cotugno, Simona Marchitti, Andrea Micaloni, Giovanna Gallo, Leonardo Schirone, Giuliano Tocci, Roberto Violini, Maria Rosaria Torrisi, Massimo Volpe, Speranza Ru Source Type: research
Community screening for atrial fibrillation in the era of smart devices
Atrial fibrillation (AF) associated strokes can be effectively prevented by oral anticoagulant therapy, but patients often miss opportunities for adequate thromboprophylaxis due to lack of symptoms or electrocardiographic (ECG) documentation of AF. Early identification of AF has become an important issue not only from the healthcare perspective but also in the social aspect, given the burden of disabling stroke related to this common arrhythmia. The latest guidelines have therefore recommended the opportunistic screening for AF by pulse palpation or single ‑lead ECG in individuals aged>65 years or in individuals with ...
Source: International Journal of Cardiology - January 9, 2019 Category: Cardiology Authors: Seung Yong Shin, Gregory Y.H. Lip Tags: Editorial Source Type: research
Connecting atrial morphology with platelet reactivity: What the left atrial appendage can tell us about the procoagulant state in atrial fibrillation
Atrial fibrillation (AF) remains the most common form of heart rhythm disorder and a leading cause for stroke and mortality. A major challenge for comprehensive AF prevention and management is the timely identification and risk stratification of patients requiring treatment.
Source: International Journal of Cardiology - December 20, 2018 Category: Cardiology Authors: Anke C. Fender Tags: Editorial Source Type: research
Secondary stroke prevention in atrial fibrillation: Still lacking pace?
The high risk of recurrent stroke due to atrial fibrillation (AF) and the ominous outcome thereafter render secondary prevention with oral anticoagulation (OA) critical [1].
Source: International Journal of Cardiology - December 15, 2018 Category: Cardiology Authors: G.D. Athanassopoulos, I. Armenis Tags: Editorial Source Type: research
Apples will never be oranges, but when you go fishing you may get a bite
Dronedarone is the newest available oral antiarrhythmic drug (AAD). In a paper by Ehrlich et al. [1] accompanying this editorial the authors report on risks for myocardial infarction (MI) and stroke in AF patients given a first prescription for dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017. They attempt to compare MI and stroke risks in dronedarone patients (n = 3498) versus those treated with all the other stated antiarrhythmic drugs (AAD) analyzed in combination (n = 17,724).
Source: International Journal of Cardiology - December 13, 2018 Category: Cardiology Authors: James A. Reiffel Tags: Editorial Source Type: research
Systematic preoperative CT scan is associated with reduced risk of stroke in minimally invasive mitral valve surgery: A meta-analysis
Minimally invasive mitral valve surgery (MIMVS) is performed with increasing frequency. However, patients undergoing MIMVS might be at increased risk of perioperative stroke, mainly due to retrograde aortic embolization during femoral cardio-pulmonary bypass. Pre-operative computed tomography (CT) screening allows visualization of the aorta and femoro-iliac vessels and individualization of the surgical approach. In this meta-analysis, we aim to determine if systematic pre-operative CT screening is associated with decreased incidence of post-operative stroke and other complications following MIMVS.
Source: International Journal of Cardiology - December 13, 2018 Category: Cardiology Authors: Jeremy R. Leonard, Matthew Henry, Mohamed Rahouma, Faiza M. Khan, Matthew Wingo, Irbaz Hameed, Antonino Di Franco, T. Sloane Guy, Leonard N. Girardi, Mario Gaudino Source Type: research
