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Slow Elevation in Protein C Activity without a PROC Mutation in a Neonate with Intracranial Hemorrhage
We report a case of hemorrhagic stroke associated with neonatal asphyxia and severe PC deficiency. Plasma PC and protein S activity 7 days after birth was 12% and 43%, respectively. No PROC mutation was found. PC levels did not exceed 20% until 2 months of age, even in the absence of consumption coagulopathy or vitamin K deficiency. Neither thromboembolic nor hemorrhagic events occurred during the infusion of activated PC concentrate (twice weekly, up to 68 days after birth). The PC activity levels gradually increased to the standard value for age by 9 months of age. The present case showed that neonatal PC deficiency with...
Source: American Journal of Perinatology Reports - April 12, 2018 Category: Perinatology & Neonatology Authors: Uehara, Erika Nakao, Hiro Tsumura, Yusuke Nakadate, Hisaya Amari, Shoichiro Fujinaga, Hideshi Tsutsumi, Yoshiyuki Kang, Dongchon Ohga, Shouichi Ishiguro, Akira Tags: Case Report Source Type: research