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A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability
This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a small-for-gestational-age (SGA) female neonate born at 32 weeks of gestation (birth weight, 911 g [ −3.8 SD]). She developed severe temperature instability with anhidrosis, growth failure, mild developmental delay, hypothyroidism, and intractable enteropathy. On day 156, her temperature reached 42.0°C; her fever persisted for 2 h with prolonged irritability. Her serum creatine kinase level incr eased to a peak value of 12,716 (normal range, 43–321) IU/L. The clinical feature was diagnosed as rhabdomyolysis ca...
Source: Neonatology - April 12, 2023 Category: Perinatology & Neonatology Source Type: research

MR Spectroscopy Shows Long Propylene Glycol Half-Life in Neonatal Brain
Conclusion: This study showed a long cerebral PG half-life of 40.7 h in neonates, unrelated to perinatal asphyxia, infection, or stroke. These findings should increase awareness of possible toxic PG concentrations in neonatal brain due to intravenous PG-containing drugs.Neonatology
Source: Neonatology - October 20, 2021 Category: Perinatology & Neonatology Source Type: research

Bioreactance Cardiac Output Trending Ability in Preterm Infants: A Single Centre, Longitudinal Study
Conclusion: The ability of BR to track changes in CO is not interchangeable with CO changes as measured by echocardiography. BR, as a trend monitor for changes in CO or SV to determine clinical decisions around interventions in neonatology, should be used with caution.Neonatology
Source: Neonatology - September 9, 2021 Category: Perinatology & Neonatology Source Type: research

Incidence Estimates of Perinatal Arterial Ischemic Stroke in Preterm- and Term-Born Infants: A National Capture-Recapture Calculation Corrected Surveillance Study
Conclusion: PAIS incidence rates in Germany, extrapolated from estimates for completeness of reporting in the largest federal state, were within the range of other population-based studies. As a novel finding, we detected symptomatic PAIS in preterm-born infants to be as common as in term-born infants although their symptoms were often unspecific.Neonatology
Source: Neonatology - April 1, 2021 Category: Perinatology & Neonatology Source Type: research

Clinical Diversity of Cerebral Sinovenous Thrombosis and Arterial Ischaemic Stroke in the Neonate: A Surveillance Study
Conclusion: The risk for AIS is about 3 times higher than that for CSVT in neonates. A higher proportion of critically ill infants in CSVT and a later onset of symptoms may indicate that perinatal and postnatal risk factors are more important for CSVT than for AIS. The data underline the need for an increased awareness of CSVT in critically ill infants.Neonatology
Source: Neonatology - March 30, 2021 Category: Perinatology & Neonatology Source Type: research

Cyanosis and Stroke due to Functional Cor Triatriatum Dexter in a Neonate
Small remnants of the right valve of the sinus venosus are commonly found in adults, but the incidence and risk associated with these embryonic remnants in neonates are not well studied. The following report describes a cyanotic neonate with a large Eustachian valve remnant creating a functional cor triatriatum dexter who was initially diagnosed with persistent pulmonary hypertension of the newborn. The cyanosis in this infant improved over the first postnatal week with conservative management, but she suffered multifocal subcortical stroke, likely related to her intracardiac shunt. The clinical presentation and questions ...
Source: Neonatology - January 9, 2018 Category: Perinatology & Neonatology Source Type: research

Cerebellar Infarction: Unusual Manifestation with Facial Palsy, Focal Seizures, and Secondary Generalization
Conclusions: In newborn infants, acute cerebellar stroke may have direct epileptogenic potential.Neonatology 2018;113:33-36
Source: Neonatology - October 25, 2017 Category: Perinatology & Neonatology Source Type: research

The Vulnerable Newborn Brain: Imaging Patterns of Acquired Perinatal Injury
Conclusions: Taken together, the acquired perinatal brain injuries can have lifelong devastating consequences, so the search for therapies must continue.Neonatology 2016;109:345-351
Source: Neonatology - June 2, 2016 Category: Perinatology & Neonatology Source Type: research