• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Less Sodium, More Potassium, or Both: Population-wide Strategies to Prevent Hypertension
Am J Physiol Renal Physiol. 2023 Jun 1. doi: 10.1152/ajprenal.00007.2023. Online ahead of print.ABSTRACTHypertension is among the most prevalent medical conditions globally and a major contributor to chronic kidney disease, cardiovascular disease, and death. Prevention through non-pharmacologic, population-level interventions is critically needed to halt this worldwide epidemic. However, there are ongoing debates as to where public policy efforts should focus. Recently the Salt Substitute and Stroke Study demonstrated the efficacy of substituting table salt with potassium salt to reduce the risk of stroke, major cardiovasc...
Source: American Journal of Physiology. Renal Physiology - June 1, 2023 Category: Physiology Authors: Voravech Nissaisorakarn George Ormseth William Earle Martha Catalina Morales-Alvarez Swapnil Hiremath Stephen P Juraschek Source Type: research

Modulation of blood pressure regulatory genes in the Agtrap ‐Plod1 locus associated with a deletion in Clcn6
In this study, we tested whether loss ofClcn6 would be protective against high salt-induced mortality. While we observed no significant differences in longevity or neuronal cell death between the SS-Clcn6 knock-out and SS-WT groups, we found that a mutation inClcn6 could be associated with changes to mRNA expression of nearbyMthfr,Nppa, andNppb genes, thereby complicating the genetic phenotype of our knockout animal. AbstractThe AGTRAP-PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, includingCLCN6,MTHFR,NPPA, andNPPB. Previous work revealed that knockout ofClcn6 on the Dahl Salt-...
Source: Physiological Reports - August 5, 2022 Category: Physiology Authors: Christine A. Klemens, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Oleg Palygin, Alexander Staruschenko Tags: ORIGINAL ARTICLE Source Type: research

Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Physiological Reviews - May 13, 2022 Category: Physiology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research

Pages: 1  2