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Specialty: Physiology
Source: Physiological Reports
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Total 110 results found since Jan 2013.
Quantification of cardiac pumping mechanics in TAVI patients: A pilot study utilizing minimally invasive method for pressure ‐volume analysis
Reconstructed pressure volume loop by LV pressure and cardiac output. AbstractThe ventriculo-arterial coupling (VAC) and left ventricle (LV) mechanics are crucial and play an important role in the pathophysiology of aortic stenosis (AS). The pressure-volume (PV) analysis is a powerful tool to study VAC and LV mechanics. We proposed a novel minimally-invasive method for PV analysis in patients with severe AS receiving transcatheter aortic valve implantation (TAVI). Patients with severe AS were prospectively enrolled in a single center. LV pressure and cardiac output were recorded before and after TAVI. We constructed the PV...
Source: Physiological Reports - September 9, 2023 Category: Physiology Authors: Tsung ‐Yu Ko,
Chia‐Chuan Chuang,
Mao‐Shin Lin,
Yi‐Chang Chen,
Ying‐Hsien Chen,
Ching‐Chang Huang,
Chih‐Fan Yeh,
Ming‐Jiuh Wang,
Kuo‐Chu Chang,
Yi‐Lwun Ho,
Hsien‐Li Kao Tags: ORIGINAL ARTICLE Source Type: research
Differential effect of gold nanoparticles on cerebrovascular function and biomechanical properties
This study provides the first evidence that GNPs affect the structure and function of the cerebrovasculature, which may be important for their development and use in biomedical applications.
Source: Physiological Reports - August 22, 2023 Category: Physiology Authors: Ryan D. Hunt,
Omid Sedighi,
Wayne M. Clark,
Amber L. Doiron,
Marilyn J. Cipolla Tags: ORIGINAL ARTICLE Source Type: research
Application of non ‐invasive bioreactance to assess hemodynamic function in patients with hypertrophic cardiomyopathy
AbstractNon-invasive technologies have become popular for the clinical evaluation of cardiac function. The present study evaluated hemodynamic response to cardiopulmonary exercise stress testing using bioreactance technology in patients with hypertrophic cardiomyopathy. The study included 29 patients with HCM (age 55 ± 15 years; 28% female) and 12 age (55 ± 14 years), and gender matched (25% female) healthy controls. All participants underwent maximal graded cardiopulmonary exercise stress testing with simultaneous non-invasive hemodynamic bioreactance and gas exchange. At rest, patients with HCM demonstrate...
Source: Physiological Reports - June 19, 2023 Category: Physiology Authors: Nduka Charles Okwose,
Amy S. Fuller,
Alaa I. Alyahya,
Sarah J. Charman,
Christopher Eggett,
Peter Luke,
Guy A. MacGowan,
Djordje G. Jakovljevic Tags: ORIGINAL ARTICLE Source Type: research
Force sensor reduced measurement error compared with verbal command during sit ‐to‐stand assessment of cerebral autoregulation
AbstractCurrent methods estimate the time delay (TD) before the onset of dynamic cerebral autoregulation (dCA) from verbal command to stand. A force sensor used during a sit-to-stand dCA measure provides an objective moment an individual stands (arise-and-off, AO). We hypothesized that the detection of AO would improve the accuracy of TD compared with estimation. We measured middle cerebral artery blood velocity (MCAv) and mean arterial pressure (MAP) for 60 s sitting followed by 2-min standing, three times separated by 20 min. TD was calculated as the time from: (1) verbal command and (2) AO, until an increase in cer...
Source: Physiological Reports - June 13, 2023 Category: Physiology Authors: Alicen A. Whitaker,
Eric D. Vidoni,
Robert N. Montgomery,
Kailee Carter,
Katelyn Struckle,
Sandra A. Billinger Tags: ORIGINAL ARTICLE Source Type: research
Sitagliptin therapy improves myocardial perfusion and arteriolar collateralization in chronically ischemic myocardium: A pilot study
In conclusion, in chronically ischemic myocardium, sitagliptin improves myocardial perfusion and arteriolar collateralization via the activation of pro-arteriogenic signaling pathways.
Source: Physiological Reports - June 11, 2023 Category: Physiology Authors: Sharif A. Sabe,
Dwight Douglas Harris,
Mark Broadwin,
Mohamed Sabra,
Cynthia M. Xu,
Debolina Banerjee,
M. Ruhul Abid,
Frank W. Sellke Tags: ORIGINAL ARTICLE Source Type: research
Allometric scaling of metabolic rate and cardiorespiratory variables in aquatic and terrestrial mammals
AbstractWhile basal metabolic rate (BMR) scales proportionally with body mass (Mb), it remains unclear whether the relationship differs between mammals from aquatic and terrestrial habitats. We hypothesized that differences in BMR allometry would be reflected in similar differences in scaling of O2 delivery pathways through the cardiorespiratory system. We performed a comparative analysis of BMR across 63 mammalian species (20 aquatic, 43 terrestrial) with aMb range from 10 kg to 5318 kg. Our results revealed elevated BMRs in small (>10 kg and <100 kg) aquatic mammals compared to small terrestrial mammal...
Source: Physiological Reports - June 5, 2023 Category: Physiology Authors: Rebecca S. He,
Stacy De Ruiter,
Tristan Westover,
Jason A. Somarelli,
Ashley M. Blawas,
Divya L. Dayanidhi,
Ana Singh,
Benjamin Steves,
Samantha Driesinga,
Lewis G. Halsey,
Andreas Fahlman Tags: ORIGINAL ARTICLE Source Type: research
Development and characterization of canine ‐specific computational models to predict pulsatile arterial hemodynamics and ventricular‐arterial coupling
AbstractPulsatile hemodynamics analyses provide important information about the ventricular-arterial system which cannot be inferred by standard blood pressure measurements. Pulse wave analysis (PWA), wave separation analysis (WSA), and wave power analysis (WPA) characterize arterial hemodynamics with limited preclinical applications. Integrating these tools into preclinical testing may enhance understanding of disease or therapeutic effects on cardiovascular function. We used a canine rapid ventricular pacing (RVP) heart failure model to: (1) Characterize hemodynamics in response to RVP and (2) assess analyses from flow w...
Source: Physiological Reports - June 3, 2023 Category: Physiology Authors: Julia C. Hotek,
Julio A. Chirinos,
Theodore J. Detwiler,
Hillary K. Regan,
Christopher P. Regan Tags: ORIGINAL ARTICLE Source Type: research
Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice
Exertional heat stroke (EHS) is a debilitating and potentially fatal condition for which few prevention strategies exist. These results suggest that a 5AAS improves Tc regulation during EHS recovery through maintaining mucosal function and integrity and that protecting the GI tract during EHS may be beneficial in some of the health consequences of EHS exposure. AbstractIncreased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AA...
Source: Physiological Reports - May 23, 2023 Category: Physiology Authors: Michelle A. King,
Astrid Grosche,
Shauna M. Ward,
Jermaine A. Ward,
Anusree Sasidharan,
Thomas A. Mayer,
Mark L. Plamper,
Xiaodong Xu,
Matthew D. Ward,
Thomas L. Clanton,
Sadasivan Vidyasagar Tags: ORIGINAL ARTICLE Source Type: research
Shear wave ultrasound elastography of the biceps brachii can be used as a precise proxy for passive elbow torque in individuals with hemiparetic stroke
Precise and objective methods for quantifying passive joint torques are absent in stroke rehabilitation, leaving rehabilitation specialists to subjectively assess its impact on function. Here, we compare shear wave ultrasound elastography of the biceps brachii muscle with a mechatronic method (criterion measure) of measuring elbow flexion torque over a range of elbow angles. Differences are evaluated between arms. Data support the clinical application of shear wave ultrasound elastography, especially in the absence of bedside mechatronics. AbstractMuscle tissue is prone to changes in composition and architecture following ...
Source: Physiological Reports - May 20, 2023 Category: Physiology Authors: Michael D. Ellis,
Netta Gurari,
Ninette T. A. Gerritsen,
Sabrina M. Lee,
Amy Wang,
Julius P. A. Dewald Tags: ORIGINAL ARTICLE Source Type: research
Different aspects of hand grip performance associated with structural connectivity of distinct sensorimotor networks in chronic stroke
Different aspects of hand grip performance may be associated with the structural connectivity of distinct sensorimotor networks in chronic stroke survivors. This knowledge may facilitate the development of personalized rehabilitation interventions to target the responsible brain network for specific motor impairments in individual patients, thus improving outcomes. AbstractKnowledge regarding the neural origins of distinct upper extremity impairments may guide the choice of interventions to target neural structures responsible for specific impairments. This cross-sectional pilot study investigated whether different brain n...
Source: Physiological Reports - April 6, 2023 Category: Physiology Authors: Christian Schranz,
Shraddha Srivastava,
Bryant A. Seamon,
Barbara Marebwa,
Leonardo Bonilha,
Viswanathan Ramakrishnan,
Janina Wilmskoetter,
Richard R. Neptune,
Steve A. Kautz,
Na Jin Seo Tags: ORIGINAL ARTICLE Source Type: research
Embolic occlusion of internal carotid artery in conscious rats: Immediate effects of cerebral ischemia
In a refinement of the embolic clot stroke model, injection of different length blood clots into the internal carotid artery of unanesthetized rats produced graded increases in arterial blood pressure, brain water content, neurological deficits, and infarct volume. The increase in arterial pressure correlated with the eventual volume of infarcted brain tissue. AbstractIn most preclinical models of focal ischemic stroke, vascular occlusion is performed under general anesthesia. However, anesthetic agents exert confounding effects on mean arterial blood pressure (MABP), cerebrovascular tone, oxygen demand, and neurotransmitt...
Source: Physiological Reports - February 17, 2023 Category: Physiology Authors: Thomas J. K. Toung,
Noah Mehr,
Marek Mirski,
Raymond C. Koehler Tags: ORIGINAL ARTICLE Source Type: research
Observational study on passive leg raising and the autonomic nervous system
This study aims to clarify these concomitant changes during PLR. A convenience number of healthy volunteers (N = 11) were recruited by advertisement in university departments. The subjects were exposed to the established PLR sequence and the heart rate (HR), mean arterial pressure (MAP), SV, and CO were sampled at 1 Hz, while electrocardiogram was recorded at 1000 Hz. Relative powers reflecting autonom ic nervous system activity were assessed from spectral analysis of HRV. In response to PLR, SV increased (12.4% ± 8.7%,p < 0.0026), while HR (−7.6% ± 4.7%,p < 0.0009) and MAP (−7.6% ± ...
Source: Physiological Reports - December 21, 2022 Category: Physiology Authors: S øren Søndergaard Tags: ORIGINAL ARTICLE Source Type: research
Impact of pressure recovery on the assessment of pulmonary homograft function using Doppler ultrasound
The presented results showed that the Doppler measurements overestimated the degree of homograft stenosis and thus the right ventricular load when the energy loss concept with pressure recovery (PR) in the pulmonary artery was neglected. Doppler measurements that ignore PR can misclassify the severity of homograft stenosis and may lead to premature surgery. AbstractRelevant pressure recovery (PR) has been shown to increase functional stenotic aortic valve orifice area and reduce left ventricular load. However, little is known about the relevance of PR in the pulmonary artery. The study examined the impact of PR using 2D-ec...
Source: Physiological Reports - December 13, 2022 Category: Physiology Authors: Jan ‐Christian Reil,
Christoph Marquetand,
Claudia Busch‐Tilge,
Jule Rohde,
Edda Bahlmann,
Anas Aboud,
Ingo Eitel,
Stephan Ensminger,
Efstratios I. Charitos,
Gert‐Hinrich Reil,
Ulrich Stierle Tags: ORIGINAL ARTICLE Source Type: research
