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Placental growth factor deficiency is associated with impaired cerebral vascular development in mice
STUDY HYPOTHESIS Placental growth factor (PGF) is expressed in the developing mouse brain and contributes to vascularization and vessel patterning. STUDY FINDING PGF is dynamically expressed in fetal mouse brain, particularly forebrain, and is essential for normal cerebrovascular development. WHAT IS KNOWN ALREADY PGF rises in maternal plasma over normal human and mouse pregnancy but is low in many women with the acute onset hypertensive syndrome, pre-eclampsia (PE). Little is known about the expression of PGF in the fetus during PE. Pgf –/– mice appear normal but recently cerebral vascular defects were docum...
Source: Molecular Human Reproduction - January 30, 2016 Category: Molecular Biology Authors: Luna, R. L., Kay, V. R., Rätsep, M. T., Khalaj, K., Bidarimath, M., Peterson, N., Carmeliet, P., Jin, A., Anne Croy, B. Tags: Articles Source Type: research