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Specialty: Biomedical Science
Source: Biomechanics and Modeling in Mechanobiology
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Total 33 results found since Jan 2013.
Post-infarct evolution of ventricular and myocardial function
Biomech Model Mechanobiol. 2023 Jul 5. doi: 10.1007/s10237-023-01734-1. Online ahead of print.ABSTRACTAdverse ventricular remodeling following acute myocardial infarction (MI) may induce ventricular dilation, fibrosis, and loss of global contractile function, possibly resulting in heart failure (HF). Understanding the relation between the time-dependent changes in material properties of the myocardium and the contractile function of the heart may further our understanding of the development of HF post-MI and guide the development of novel therapies. A finite element model of cardiac mechanics was used to model MI in a thic...
Source: Biomechanics and Modeling in Mechanobiology - July 5, 2023 Category: Biomedical Science Authors: K L P M Janssens M Kraamer L Barbarotta P H M Bovendeerd Source Type: research
Effects of myocardial sheetlet sliding on left ventricular function
Biomech Model Mechanobiol. 2023 May 6. doi: 10.1007/s10237-023-01721-6. Online ahead of print.ABSTRACTLeft ventricle myocardium has a complex micro-architecture, which was revealed to consist of myocyte bundles arranged in a series of laminar sheetlets. Recent imaging studies demonstrated that these sheetlets re-orientated and likely slided over each other during the deformations between systole and diastole, and that sheetlet dynamics were altered during cardiomyopathy. However, the biomechanical effect of sheetlet sliding is not well-understood, which is the focus here. We conducted finite element simulations of the left...
Source: Biomechanics and Modeling in Mechanobiology - May 6, 2023 Category: Biomedical Science Authors: Yu Zheng Wei Xuan Chan Sonia Nielles-Vallespin Andrew D Scott Pedro F Ferreira Hwa Liang Leo Choon Hwai Yap Source Type: research
A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling
Biomech Model Mechanobiol. 2023 Jan 13. doi: 10.1007/s10237-023-01690-w. Online ahead of print.ABSTRACTThe course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented by a previously described low-order, wall volume-preserving model that includes torsion and base-to-apex and circumferential wa...
Source: Biomechanics and Modeling in Mechanobiology - January 13, 2023 Category: Biomedical Science Authors: Michael J Moulton Timothy W Secomb Source Type: research
The dependency of fetal left ventricular biomechanics function on myocardium helix angle configuration
Biomech Model Mechanobiol. 2022 Dec 22. doi: 10.1007/s10237-022-01669-z. Online ahead of print.ABSTRACTThe helix angle configuration of the myocardium is understood to contribute to the heart function, as finite element (FE) modeling of postnatal hearts showed that altered configurations affected cardiac function and biomechanics. However, similar investigations have not been done on the fetal heart. To address this, we performed image-based FE simulations of fetal left ventricles (LV) over a range of helix angle configurations, assuming a linear variation of helix angles from epicardium to endocardium. Results showed that...
Source: Biomechanics and Modeling in Mechanobiology - December 22, 2022 Category: Biomedical Science Authors: Laura Green Wei Xuan Chan Meifeng Ren Citra Nurfarah Zaini Mattar Lik Chuan Lee Choon Hwai Yap Source Type: research
Numerical investigation of mucociliary clearance using power law and thixotropic mucus layers under discrete and continuous cilia motion
Biomech Model Mechanobiol. 2022 Oct 12:1-17. doi: 10.1007/s10237-022-01645-7. Online ahead of print.ABSTRACTMucus layer movement inside the airway system is an important phenomenon as the first defensive mechanism against pathogens. This research deals with the mucus velocity variations inside the nasal cavity using two different power law and thixotropic mucus layers. The cilia movement is replaced with four cyclic velocity profiles at the lower boundary of the mucus layer, while the upper boundary is exposed to the free-slip condition. The effects of boundary conditions and different fluid parameters are evaluated on the...
Source: Biomechanics and Modeling in Mechanobiology - October 12, 2022 Category: Biomedical Science Authors: M A Modaresi Source Type: research
