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Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis.
Abstract Varicella-zoster virus (VZV) is the causative agent of chicken pox (varicella) and shingles (zoster). Although considered benign diseases, both varicella and zoster can cause complications. Zoster is painful and can lead to post herpetic neuralgia. VZV has also been linked to stroke, related to giant cell arteritis in some cases. Vaccines are available but the attenuated vaccine is not recommended in immunocompromised individuals and the efficacy of the glycoprotein E (gE) based subunit vaccine has not been evaluated for the prevention of varicella. A hallmark of VZV pathology is the formation of multinuc...
Source: Biochemical Society Transactions - December 1, 2020 Category: Biochemistry Authors: Oliver SL, Zhou M, Arvin AM Tags: Biochem Soc Trans Source Type: research