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Specialty: Cancer & Oncology
Source: Pediatric Blood and Cancer

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Total 32 results found since Jan 2013.

Hydroxyurea for Primary Stroke Prevention: The time draweth nigh
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Marvin E Reid Tags: COMMENTARY Source Type: research

The management of childhood cancer survivors at risk for stroke: A Delphi survey of regional experts
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - August 10, 2018 Category: Cancer & Oncology Authors: Lisa B.Kenney , BethanyAmes , Alexis L.Michaud , David N.Williams , Peter E.Manley , Nicole J.Ullrich Source Type: research

Annual stroke incidence in Nigerian children with sickle cell disease and elevated TCD velocities treated with hydroxyurea
Pediatric Blood&Cancer, EarlyView.
Source: Pediatric Blood and Cancer - May 24, 2018 Category: Cancer & Oncology Authors: IkeOluwaLagunju , B.J.Brown , A.O.Oyinlade , A.Asinobi , J.Ibeh , A.Esione , O.O.Sodeinde Source Type: research

Deficiency of ADA2 mimicking autoimmune lymphoproliferative syndrome in the absence of livedo reticularis and vasculitis
We present a 5‐year‐old female who presented with features that mimicked autoimmune lymphoproliferative syndrome (ALPS) in the absence of classic features of DADA2. Exome sequencing identified a novel homozygous splicing variant in ADA2 c.882‐2A > G. Patient responded to anti‐ tumor necrosis factor medication and is in complete remission. Hematologists should be aware of various hematological presentations of DADA2, including ALPS‐like disorder, that might lack vasculitis and livedo reticularis to prevent delay in initiating optimal therapy.
Source: Pediatric Blood and Cancer - December 22, 2017 Category: Cancer & Oncology Authors: Abdulrahman Alsultan, Enas Basher, Jubran Alqanatish, Reem Mohammed, Majid Alfadhel Tags: BRIEF REPORT Source Type: research

An analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes
ConclusionInpatient hospitalizations for secondary manifestations of pediatric SCD were associated with significant healthcare expenditures. Patients with an increased statistical risk for death during hospitalization included Caucasians with SCD complications of ACS and VOC, and patients <1‐year‐old with ACS. Further research is needed to substantiate the associated clinical significance of these findings.
Source: Pediatric Blood and Cancer - August 12, 2017 Category: Cancer & Oncology Authors: Laura M. Bou ‐Maroun, Fabien Meta, Curtis J. Hanba, Andrew D. Campbell, Gregory A. Yanik Tags: RESEARCH ARTICLE Source Type: research

Increased complications of chronic erythrocytapheresis compared with manual exchange transfusions in children and adolescents with sickle cell disease
ConclusionaRBCX may have increased complication risks compared with MET for chronic transfusion therapy in SCD. Risks and benefits of aRBCX and MET should be considered when selecting a chronic transfusion modality. Transfusion therapy modalities should be compared in prospective studies for stroke prevention in children with SCD.
Source: Pediatric Blood and Cancer - May 19, 2017 Category: Cancer & Oncology Authors: Deborah Woods, Robert J. Hayashi, Michael M. Binkley, Gianna W. Sparks, Monica L. Hulbert Tags: RESEARCH ARTICLE Source Type: research

Prevalence of cardiovascular late sequelae in long ‐term survivors of childhood cancer: A systematic review and meta‐analysis
ConclusionThis review showed the vast range of cardiovascular late effects after childhood or adolescent cancer therapy. The differences between the papers prevented drawing a conclusive picture of the prevalence of cardiovascular late effects. Large cohort studies and better reporting are needed to improve the knowledge on this topic.
Source: Pediatric Blood and Cancer - February 16, 2017 Category: Cancer & Oncology Authors: Peter Scholz ‐Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig Tags: Research Article Source Type: research

The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene
ConclusionsThe genotype of double‐PROC mutants might show less diversity than heterozygous mutants in terms of the timing of the onset of thrombophilia (newborn onset or late onset).
Source: Pediatric Blood and Cancer - January 22, 2017 Category: Cancer & Oncology Authors: Hirofumi Inoue, Shin ‐ichi Terachi, Takeshi Uchiumi, Tetsuji Sato, Michiyo Urata, Masataka Ishimura, Yui Koga, Taeko Hotta, Toshiro Hara, Dongchon Kang, Shouichi Ohga Tags: Research Article Source Type: research

Transcranial Doppler in hemoglobin SC disease
Conclusion: These results suggest that a different cut‐off value for abnormal TCD velocities could be considered for patients with HbSC. Additional studies are warranted to determine the actual risk of stroke in HbSC genotype associated with this possible TCD risk value.
Source: Pediatric Blood and Cancer - December 12, 2016 Category: Cancer & Oncology Authors: Camilo Vieira, Carolina Nogueira Costa Oliveira, Ludmila Ara újo Borges Figueiredo, Rayra Pereira Santiago, Corynne Stephanie Ahouefa Adanho, Sanzio Silva Santana, Caroline Lang Burak, Isa Menezes Lyra, Marilda Souza Goncalves Tags: Research Article Source Type: research

Genotypes and phenotypes of protein S deficiency in Thai children with thromboembolism
Abstract The prevalence of protein S (PS) deficiency in Asian patients with venous thromboembolism is around 8–30%, higher than that in Caucasian populations. The present study reports the genotypes (including one novel mutation) and phenotypes of children with PS deficiency at a tertiary care institute. A total of six patients were included, three with arterial ischemic stroke, two with cerebral venous sinus thrombosis, and one with deep vein thrombosis. PS mutations were identified in four patients: p.R355C, p.G336D, p.E67A, and p.N188KfsX9. p.N188KfsX9 is a novel mutation with less than 20% PS activity noted in heterozygotes.
Source: Pediatric Blood and Cancer - October 16, 2016 Category: Cancer & Oncology Authors: Patcharee Komwilaisak, Werasak Sasanakul, Ampaiwan Chuansumrit, Somjai Kanjanapongkul, Somporn Wangruangsathit, Apasri Lusawat, Pimlak Charoenkwan, Nongnuch Sirachainan Tags: Brief Report Source Type: research

Cranial epidural hematomas: A case series and literature review of this rare complication associated with sickle cell disease
ConclusionsAlthough rare, cranial epidural hematoma can be fatal and should be considered in patients with acute neurological symptoms.
Source: Pediatric Blood and Cancer - September 12, 2016 Category: Cancer & Oncology Authors: Jennifer Hamm, Nisha Rathore, Pearlene Lee, Zachary LeBlanc, Jeffrey Lebensburger, Emily Riehm Meier, Janet L. Kwiatkowski Tags: Research Article Source Type: research

Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
ConclusionsSCD‐related complications are more frequent in Indian children than that observed in CSSCD. Further study is indicated to define SCD phenotype in India.
Source: Pediatric Blood and Cancer - June 9, 2016 Category: Cancer & Oncology Authors: Dipty Jain, Aishwarya Arjunan, Vijaya Sarathi, Harshwardhan Jain, Amol Bhandarwar, Marike Vuga, Lakshmanan Krishnamurti Tags: Research Article Source Type: research

Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy
ConclusionsThe rate of overt and silent infarct recurrence was significantly lower following indirect cerebral revascularization. A prospective study of cerebral revascularization in children with SCD is needed.
Source: Pediatric Blood and Cancer - April 21, 2016 Category: Cancer & Oncology Authors: Erin M. Hall, Jeffrey Leonard, Jodi L. Smith, Kristin P. Guilliams, Michael Binkley, Robert J. Fallon, Monica L. Hulbert Tags: Research Article Source Type: research

Neurological PRESentations in Sickle Cell Patients Are Not Always Stroke: A Review of Posterior Reversible Encephalopathy Syndrome in Sickle Cell Disease
Acute neurological changes in sickle cell disease (SCD) patients often raise the suspicion for stroke. Posterior reversible encephalopathy syndrome (PRES) can mimic stroke in its clinical presentation. We aimed to (i) review the PRES literature in SCD patients including clinical presentation, risk factors, pathophysiology, and management and (ii) elucidate the distinction between PRES and stroke in SCD. The exact pathophysiology of PRES in SCD remains elusive but is likely multifactorial and related to sickling, ischemia, and chronic anemia predisposing to vasogenic edema. PRES and stroke in SCD are distinguishable conditi...
Source: Pediatric Blood and Cancer - February 13, 2016 Category: Cancer & Oncology Authors: Ziad Solh, Michael S. Taccone, Samantha Marin, Uma Athale, Vicky R. Breakey Tags: REVIEW Source Type: research

Glucose‐6‐Phosphate Dehydrogenase Deficiency in Brazilian Children With Sickle Cell Anemia is not Associated With Clinical Ischemic Stroke or High‐Risk Transcranial Doppler
ConclusionsOur study demonstrated that G6PD molecular deficiency was not associated either with clinical ischemic stroke or high‐risk TCD. Similarly, we found no associations between G6PD enzyme activity and stroke or high‐risk TCD. Small sample size precludes definitive conclusions.
Source: Pediatric Blood and Cancer - February 3, 2016 Category: Cancer & Oncology Authors: André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Cibele Velloso‐Rodrigues, Célia Maria Silva, Marcos Borato Viana Tags: Research Article Source Type: research