Filtered By:
Specialty: Cancer & Oncology
Source: Pediatric Blood and Cancer
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 32 results found since Jan 2013.
Contribution of sickle cell disease to the pediatric stroke burden among hospital discharges of African‐Americans—United States, 1997–2012
ConclusionsSCD is a leading risk factor to pediatric stroke in African‐American children. Reducing the number of strokes among children with SCD would have a significant impact on the rate of strokes among African‐American children. Preventative intervention may be modifying initial age of presentation of stroke in children with SCD. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - July 14, 2015 Category: Cancer & Oncology Authors: Charlotte Baker, Althea M. Grant, Mary G. George, Scott D. Grosse, Thomas V. Adamkiewicz Tags: Research Article Source Type: research
Implementation of transcranial Doppler ultrasonography screening and primary stroke prevention in urban and rural sickle cell disease populations
ConclusionsWe report here data describing primary stroke prophylaxis in rural patients. SOC rates are similar between the two clinical settings. While implementation of primary stroke prevention in rural patients was difficult, rural TCD screening is feasible and can achieve SOC equal to that in an urban setting. This suggests that barriers exist in provided primary stroke prevention to all patients. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - November 8, 2014 Category: Cancer & Oncology Authors: Samiya Hussain, Fenwick Nichols, Latanya Bowman, Hongyan Xu, Cindy Neunert Tags: Research Article Source Type: research
Glucose‐6‐Phosphate Dehydrogenase Deficiency in Brazilian Children With Sickle Cell Anemia is not Associated With Clinical Ischemic Stroke or High‐Risk Transcranial Doppler
ConclusionsOur study demonstrated that G6PD molecular deficiency was not associated either with clinical ischemic stroke or high‐risk TCD. Similarly, we found no associations between G6PD enzyme activity and stroke or high‐risk TCD. Small sample size precludes definitive conclusions.
Source: Pediatric Blood and Cancer - February 3, 2016 Category: Cancer & Oncology Authors: André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Cibele Velloso‐Rodrigues, Célia Maria Silva, Marcos Borato Viana Tags: Research Article Source Type: research
Stroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia
ConclusionStroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia, and further investigation is needed on the role of anti‐platelet agents in this high‐risk population. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - March 18, 2013 Category: Cancer & Oncology Authors: Suvankar Majumdar, Samantha Webb, Erin Norcross, Venkat Mannam, Naveed Ahmad, Seth Lirette, Rathi Iyer Tags: Research Article Source Type: research
Chronic blood transfusion for primary and secondary stroke prevention in Nigerian children with sickle cell disease: A 5‐year appraisal
ConclusionHigh economic costs, unavailability of blood, need to regularly seek for blood donors, cultural beliefs, and high frequency of transfusion reactions are major challenges to a successful CBT program in Nigeria. There is a need for government subsidy on blood transfusions and improved efforts towards provision of safe and affordable blood. Pediatr Blood Cancer. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 19, 2013 Category: Cancer & Oncology Authors: I.A. Lagunju, B.J. Brown, O.O. Sodeinde Tags: Research Article Source Type: research
Transcranial Doppler Velocity and Brain MRI/MRA Changes in Children With Sickle Cell Anemia on Chronic Transfusions to Prevent Primary Stroke
ConclusionsFor children with SCA and abnormal TCD velocities, transfusions lower TCD velocities and help prevent stroke, but do not always result in normal velocities or protect against progression of cerebral vasculopathy. Improved adherence to transfusion goals may improve on‐treatment TCD velocities. Pediatr Blood Cancer 2013;9999:XX–XX. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 26, 2013 Category: Cancer & Oncology Authors: Vivien A. Sheehan, Eileen N. Hansbury, Matthew P. Smeltzer, Gail Fortner, M. Beth McCarville, Banu Aygun Tags: Research Article Source Type: research
Hydroxyurea use in prevention of stroke recurrence in children with sickle cell disease in a developing country: A cost effectiveness analysis
We undertook a cost effectiveness analysis (CEA) of hydroxyurea (HU) in preventing stroke recurrence and/or death. We followed 43 children with sickle cell disease from 2000 to 2009 after having a first clinical stroke, of whom 10 opted for HU therapy. HU use led to decreased stroke recurrence and death without significantly increasing the annual cost of care per patient (J$83,250 vs. J$76,901, P = 0.491). The incremental cost effectiveness ratio (ICER) for prevention of stroke recurrence amounted to J$169,238 (US$1,900), while that for death prevention equalled J$635,843 (US$7,140). HU may be recommended when safe and...
Source: Pediatric Blood and Cancer - April 30, 2015 Category: Cancer & Oncology Authors: Colette Cunningham‐Myrie, Abdullahi Abdulkadri, Andre Waugh, Susanna Bortolusso Ali, Lesley‐Gaye King, Jennifer Knight‐Madden, Marvin Reid Tags: Brief Report Source Type: research
Neurological PRESentations in Sickle Cell Patients Are Not Always Stroke: A Review of Posterior Reversible Encephalopathy Syndrome in Sickle Cell Disease
Acute neurological changes in sickle cell disease (SCD) patients often raise the suspicion for stroke. Posterior reversible encephalopathy syndrome (PRES) can mimic stroke in its clinical presentation. We aimed to (i) review the PRES literature in SCD patients including clinical presentation, risk factors, pathophysiology, and management and (ii) elucidate the distinction between PRES and stroke in SCD. The exact pathophysiology of PRES in SCD remains elusive but is likely multifactorial and related to sickling, ischemia, and chronic anemia predisposing to vasogenic edema. PRES and stroke in SCD are distinguishable conditi...
Source: Pediatric Blood and Cancer - February 13, 2016 Category: Cancer & Oncology Authors: Ziad Solh, Michael S. Taccone, Samantha Marin, Uma Athale, Vicky R. Breakey Tags: REVIEW Source Type: research
Capacity building and stroke risk assessment in Nigerian children with sickle cell anaemia
ConclusionEffective capacity building of middle level manpower is feasible and can provide a credible TCD screening service to communities with a high demand and a shortage of trained professionals. The pattern of TCD abnormalities seen in Africa are comparable to those obtained in several previous worldwide reports. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 30, 2014 Category: Cancer & Oncology Authors: Kofo Soyebi, Titilope Adeyemo, Oyesola Ojewunmi, Funmi James, Kunle Adefalujo, Olu Akinyanju Tags: Research Article Source Type: research
Primary stroke prevention in Nigerian children with sickle cell disease (SPIN): Challenges of conducting a feasibility trial
ConclusionA hydroxyurea trial (NCT01801423) for children with SCD is feasible in sub‐Saharan Africa; however, extensive training and resources are needed to build a global patient oriented multi‐disciplinary research team with a common purpose. Pediatr Blood Cancer. © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - November 14, 2014 Category: Cancer & Oncology Authors: Najibah A. Galadanci, Shehu U. Abdullahi, Musa A. Tabari, Shehi Abubakar, Raymond Belonwu, Auwal Salihu, Kathleen Neville, Fenella Kirkham, Baba Inusa, Yu Shyr, Sharon Phillips, Adetola A. Kassim, Lori C. Jordan, Muktar H. Aliyu, Brittany V. Covert, Micha Tags: Research Article Source Type: research
A Cross‐Sectional Cohort Study of Cerebrovascular Disease and Late Effects After Radiation Therapy for Craniopharyngioma
ConclusionsPatients with craniopharyngioma treated with RT have a high prevalence of stroke and vascular abnormalities, particularly those with low HDL and longer duration of time since RT. There is a trend to suggest that continual GH replacement may reduce the risk of stroke. These patients should undergo careful monitoring and aggressive modification of stroke risk factors.
Source: Pediatric Blood and Cancer - January 12, 2016 Category: Cancer & Oncology Authors: Andrea C. Lo, A. Fuchsia Howard, Alan Nichol, Haroon Hasan, Monty Martin, Manraj Heran, Karen Goddard Tags: Research Article Source Type: research
Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort
ConclusionHU appears to significantly reduce TCD velocities in Nigerian children with SCA and elevated velocities ≥170 cm/sec with beneficial effect on the haematological profile. HU may provide an effective approach to primary stroke prevention, particularly in Africa. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - April 2, 2015 Category: Cancer & Oncology Authors: IkeOluwa Lagunju, Biobele J. Brown, Olugbemiro Sodeinde Tags: Research Article Source Type: research
Transcranial Doppler in hemoglobin SC disease
Conclusion: These results suggest that a different cut‐off value for abnormal TCD velocities could be considered for patients with HbSC. Additional studies are warranted to determine the actual risk of stroke in HbSC genotype associated with this possible TCD risk value.
Source: Pediatric Blood and Cancer - December 12, 2016 Category: Cancer & Oncology Authors: Camilo Vieira, Carolina Nogueira Costa Oliveira, Ludmila Ara újo Borges Figueiredo, Rayra Pereira Santiago, Corynne Stephanie Ahouefa Adanho, Sanzio Silva Santana, Caroline Lang Burak, Isa Menezes Lyra, Marilda Souza Goncalves Tags: Research Article Source Type: research
Prevalence of cardiovascular late sequelae in long ‐term survivors of childhood cancer: A systematic review and meta‐analysis
ConclusionThis review showed the vast range of cardiovascular late effects after childhood or adolescent cancer therapy. The differences between the papers prevented drawing a conclusive picture of the prevalence of cardiovascular late effects. Large cohort studies and better reporting are needed to improve the knowledge on this topic.
Source: Pediatric Blood and Cancer - February 16, 2017 Category: Cancer & Oncology Authors: Peter Scholz ‐Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig Tags: Research Article Source Type: research
Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
ConclusionsSCD‐related complications are more frequent in Indian children than that observed in CSSCD. Further study is indicated to define SCD phenotype in India.
Source: Pediatric Blood and Cancer - June 9, 2016 Category: Cancer & Oncology Authors: Dipty Jain, Aishwarya Arjunan, Vijaya Sarathi, Harshwardhan Jain, Amol Bhandarwar, Marike Vuga, Lakshmanan Krishnamurti Tags: Research Article Source Type: research
