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Stroke of luck: Scientists discover target for stroke therapy in blood-brain barrier
(Tokyo University of Science) The blood-brain barrier prevents immune cells from circulating freely in the brain, and the breakdown of its function is a major cause of post-stroke inflammation. Now, for the first time, researchers have identified how a toxic stroke byproduct, acrolein, could activate the barrier-degrading enzyme proheparanase (proHPSE). The research group has discovered that proHPSE degrades the glycocalyx within the post-stroke brain's blood vessels, providing hope for new and effective therapeutics against post-stroke inflammation.
Source: EurekAlert! - Cancer - February 22, 2021 Category: Cancer & Oncology Source Type: news

Survivors of childhood cancer have high-risk of recurrent stroke
(University of California - San Francisco) A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.
Source: EurekAlert! - Cancer - August 26, 2015 Category: Cancer & Oncology Source Type: news

Brainstem discovered as important relay site after stroke
(University of Zurich) After a stroke, sufferers are often faced with the problem of severe movement impairment. Researchers at the Brain Research Institute of the University of Zurich have now discovered that the brainstem could play a major role in the recovery of motor functions. The projection of neurons from this ancient part of the brain into the spinal cord leads to the neural impulses needed for motion being rerouted.
Source: EurekAlert! - Cancer - February 25, 2014 Category: Cancer & Oncology Source Type: news

Study links severe sleep apnea to increased risk of stroke, cancer and death
(American Academy of Sleep Medicine) A new study shows that moderate to severe obstructive sleep apnea is independently associated with an increased risk of stroke, cancer and death.
Source: EurekAlert! - Cancer - April 14, 2014 Category: Cancer & Oncology Source Type: news

Glutamate imaging better than MR spectroscopy in first 3 hours after ischemic stroke
(American Roentgen Ray Society) Glutamate imaging reveals ischemic lesions in the first 3 hours after stroke that are not distinguishable in T1-weighted and T2-weighted imaging.
Source: EurekAlert! - Cancer - May 7, 2014 Category: Cancer & Oncology Source Type: news

Walking faster after stroke, managing chemobrain after cancer
(Allina Health) New gate guidelines developed by Courage Kenny Rehabilitation Institute doubled stroke patients' walking speeds. And, occupational therapy helped breast cancer patients manage chemobrain.
Source: EurekAlert! - Cancer - November 29, 2016 Category: Cancer & Oncology Source Type: news

Kidney disease patients have higher out-of-pocket costs than stroke and cancer patients
(Loyola University Health System) Patients who have chronic kidney disease but are not on dialysis have higher out-of-pocket healthcare expenses than even stroke and cancer patients, according to a Loyola University Chicago study published in BMC Nephrology.
Source: EurekAlert! - Cancer - January 17, 2017 Category: Cancer & Oncology Source Type: news

microRNA may reduce stroke risk
(Technical University of Munich (TUM)) The molecule microRNA-210 stabilises deposits in the carotid artery and can prevent them from tearing. Thus, it may prevent dangerous blood clots from forming. This is what scientists headed by Prof. Lars M ä gdefessel, Professor of Vascular Biology at the Technical University of Munich (TUM) and head of a junior scientist group in the German Centre for Cardiovascular Research (DZHK) have discovered. Their results open up new treatment approaches to reduce stroke risk in patients with carotid arteries at risk of rupturing.
Source: EurekAlert! - Cancer - April 13, 2017 Category: Cancer & Oncology Source Type: news

Some stroke survivors may have underlying cancer
(European Society for Medical Oncology) Some stroke survivors may have underlying cancer, according to an observational study to be presented at the ESMO 2017 Congress in Madrid.
Source: EurekAlert! - Cancer - September 6, 2017 Category: Cancer & Oncology Source Type: news

Stroke of genius: Drug could target leading cause in young
(Centenary Institute) A study led by researchers at the Centenary Institute has identified a drug currently used to treat cancer patients, as a potential treatment option for a leading cause of stroke in young people.
Source: EurekAlert! - Cancer - November 7, 2018 Category: Cancer & Oncology Source Type: news

Study: Increased risk of heart attack, stroke in months leading up to a cancer diagnosis
(American Society of Hematology) Older adults with cancer are more likely to have had a heart attack or stroke in the months prior to their cancer diagnosis compared with similar adults who do not have cancer during the same period, according to a report published online today in Blood.
Source: EurekAlert! - Cancer - December 21, 2018 Category: Cancer & Oncology Source Type: news

Genetic variant linked to increased stroke risk in childhood cancer survivors treated with CRT
(American Association for Cancer Research) A common single nucleotide polymorphism (SNP) was associated with increased risk for developing stroke in childhood survivors who received cranial radiation therapy (CRT) for their primary cancer, according to results presented at the AACR Annual Meeting 2019, March 29-April 3.
Source: EurekAlert! - Cancer - April 2, 2019 Category: Cancer & Oncology Source Type: news

Oncotarget: DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques
(Impact Journals LLC) Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.
Source: EurekAlert! - Cancer - March 13, 2020 Category: Cancer & Oncology Source Type: news

No increased risk of fatal CV events for breast cancer patients on newer hormone therapy
(Kaiser Permanente) In a new study from Kaiser Permanente, researchers found the use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke.
Source: EurekAlert! - Cancer - April 21, 2016 Category: Cancer & Oncology Source Type: news

Releasing an immune system brake could help patients with rare but fatal brain infection
(NIH/National Institute of Neurological Disorders and Stroke) The anti-cancer drug pembrolizumab has shown promise in slowing or stopping the progression of progressive multifocal leukoencephalopathy (PML), a typically fatal infection of the brain caused by the JC virus (JCV). This finding comes from a small-scale study by scientists at National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. The study appears in the New England Journal of Medicine.
Source: EurekAlert! - Cancer - April 10, 2019 Category: Cancer & Oncology Source Type: news

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