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Common genetic variation influencing human white matter microstructure
Brain regions communicate with each other through tracts of myelinated axons, commonly referred to as white matter. We identified common genetic variants influencing white matter microstructure using diffusion magnetic resonance imaging of 43,802 individuals. Genome-wide association analysis identified 109 associated loci, 30 of which were detected by tract-specific functional principal components analysis. A number of loci colocalized with brain diseases, such as glioma and stroke. Genetic correlations were observed between white matter microstructure and 57 complex traits and diseases. Common variants associated with whi...
Source: Science: Current Issue - June 17, 2021 Category: Science Authors: Zhao, B., Li, T., Yang, Y., Wang, X., Luo, T., Shan, Y., Zhu, Z., Xiong, D., Hauberg, M. E., Bendl, J., Fullard, J. F., Roussos, P., Li, Y., Stein, J. L., Zhu, H. Tags: Genetics, Online Only r-articles Source Type: research

This Week in Science Randomized clinical trials for mice
Author: Katrina L. Kelner
Source: Science: Current Issue - August 7, 2015 Category: Science Authors: Katrina L. Kelner Tags: Stroke Treatment Source Type: research

Business Office Feature The Art and Science of Traditional Medicine Part 2: Multidisciplinary Approaches for Studying Traditional Medicine
In this second of three special supplements, herbal genomics as a novel approach for revolutionizing research on, and ultimately use of, traditional herbal medicines and other materia medica, as well as advances in their quality control and standardization, is highlighted. A prominent focus is the U.S. Food and Drug Administration’s practical framework for developing botanicals (including traditional medicines) into new drugs based on the same standards as small molecule drugs. The application of mechanistic studies to drug discovery and development from traditional therapies is discussed, with an emphasis on preclinical...
Source: Science: Current Issue - January 15, 2015 Category: Science Authors: Science Magazine (mailto:soleditor at aaas.org) Tags: CUSTOM PUBLISHING OFFICE SPONSORED SUPPLEMENT Source Type: research

Report A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
Astrocytes can produce neuroblasts in response to stroke and can be artificially triggered to do so in the absence of injury. Authors: Jens P. Magnusson, Christian Göritz, Jemal Tatarishvili, David O. Dias, Emma M. K. Smith, Olle Lindvall, Zaal Kokaia, Jonas Frisén
Source: Science: Current Issue - October 10, 2014 Category: Science Authors: Jens P. Magnusson Source Type: research

This Week in Science
The when of Mediterranean water outflow | Improving stroke recovery by timing treatment | Not too fast, not too slow, somewhere in between | Male chimps evolve faster with age | Tilting just right makes atoms tunnel | Taking a broader view of cancer imaging | Cycling water through the transition zone | Copper for breast cancer metastasis | The versatility of epithelial stem cells | Testing nonlocality for many particles | Avoiding back-action in quantum measurements | Dissecting how signaling directs axon growth | The population structure of Native Mexicans | Pausing for control of gene expression | Many connections are no...
Source: Science: Current Issue - June 13, 2014 Category: Science Authors: H. Jesse Smith Tags: Paleoceanography Source Type: research

Research Article Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
A rat model of stroke shows that the rebuilding of spinal circuits in response to training is time-sensitive. Authors: A. S. Wahl, W. Omlor, J. C. Rubio, J. L. Chen, H. Zheng, A. Schröter, M. Gullo, O. Weinmann, K. Kobayashi, F. Helmchen, B. Ommer, M. E. Schwab
Source: Science: Current Issue - June 13, 2014 Category: Science Authors: A. S. Wahl Source Type: research

Editorial Reproducibility
Science advances on a foundation of trusted discoveries. Reproducing an experiment is one important approach that scientists use to gain confidence in their conclusions. Recently, the scientific community was shaken by reports that a troubling proportion of peer-reviewed preclinical studies are not reproducible. Because confidence in results is of paramount importance to the broad scientific community, we are announcing new initiatives to increase confidence in the studies published in Science. For preclinical studies (one of the targets of recent concern), we will be adopting recommendations of the U.S. National Institute...
Source: Science: Current Issue - January 17, 2014 Category: Science Authors: Marcia McNutt Source Type: research

Editors' Choice
Education: Self-Efficacy Is the Key | Neuroscience: Stroke Recovery | Cancer: Highway Deconstruction | Neuroscience: Finding Parallels | Biochemistry: Four Closure | Materials Science: Making Mg Magnificent | Applied Physics: Slowly Does It
Source: Science: Current Issue - September 9, 2013 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research

Report Cytochrome P450 Drives a HIF-Regulated Behavioral Response to Reoxygenation by C. elegans
A worm model of ischemia-reperfusion injury reveals protective mechanisms potentially relevant to stroke and heart attack.Authors: Dengke K. Ma, Michael Rothe, Shu Zheng, Nikhil Bhatla, Corinne L. Pender, Ralph Menzel, H. Robert Horvitz
Source: Science: Current Issue - August 3, 2013 Category: Science Authors: Dengke K. Ma Source Type: research