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Evolving concepts in the management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation
Eur J Intern Med. 2022 May 24:S0953-6205(22)00171-6. doi: 10.1016/j.ejim.2022.05.002. Online ahead of print.ABSTRACTThromboembolic and bleeding complications negatively impact recovery and survival after transcatheter aortic valve implantation (TAVI). Particularly, there is a considerable risk of ischaemic stroke and vascular access related bleeding, as well as spontaneous gastro-intestinal bleeding. Therefore, benefit and harm of antithrombotic therapy should be carefully balanced. This review summarizes current evidence on peri- and post-procedural antithrombotic treatment. Indeed, in recent years, the management of anti...
Source: European Journal of Internal Medicine - May 27, 2022 Category: Internal Medicine Authors: Dirk Jan van Ginkel Willem L Bor Leo Veenstra Arnoud W J van 't Hof Enrico Fabris Source Type: research

P2Y12 inhibitors plus aspirin for acute treatment and secondary prevention in minor stroke and high-risk transient ischemic attack: A systematic review and meta-analysis
CONCLUSIONS: Early administration of P2Y12 inhibitors plus aspirin in patients with acute non-cardioembolic minor ischemic stroke or TIA reduced the incidence of ischemic stroke recurrence, impacting more significantly than the increased bleeding risk and influencing patients' quality of life by reducing disabling stroke.PMID:35331593 | DOI:10.1016/j.ejim.2022.03.017
Source: European Journal of Internal Medicine - March 25, 2022 Category: Internal Medicine Authors: Fulvio Pomero Eleonora Galli Marta Bellesini Lorenzo Maroni Alessandro Squizzato Source Type: research

Antithrombotic treatment in patients with atrial fibrillation undergoing coronary angioplasty: rational convincement and supporting evidence.
CONCLUSIONS: Our findings suggest that DT is safer than TT with regard to occurrence of major bleeding. DT with a direct oral anticoagulant plus clopidogrel at discharge could be effective in most patients, maintaining aspirin in periprocedural phase and as longer "tailored" treatment for patients at higher ischemic risk. PMID: 32063489 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - February 12, 2020 Category: Internal Medicine Authors: Ricottini E, Nenna A, Melfi R, Giannone S, Lusini M, Sciascio GD, Chello M, Ussia GP, Grigioni F Tags: Eur J Intern Med Source Type: research

Different impact of aspirin on renal progression in patients with predialysis advanced chronic kidney disease with or without previous stroke.
CONCLUSIONS: There was no significant benefit in preventing ischemic stroke in the patients with advanced CKD who received aspirin therapy. Furthermore, the use of aspirin was associated with the risk of renal failure in the patients with advanced CKD without previous stroke. PMID: 27884500 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - November 20, 2016 Category: Internal Medicine Authors: Hsiao KC, Huang JY, Lee CT, Hung TW, Liaw YP, Chang HR Tags: Eur J Intern Med Source Type: research

Switching from aspirin to clopidogrel in patients with aspirin resistance after an ischemic stroke. Is it a good solution?
PMID: 24484620 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - January 28, 2014 Category: Internal Medicine Authors: Castilla-Guerra L, Del Carmen Fernandez-Moreno M, Sierra Navas-Alcantara M, Jimenez-Gonzalo F Tags: Eur J Intern Med Source Type: research

Hospitalized patients with atrial fibrillation compared to those included in recent trials on novel oral anticoagulants: A population-based study.
CONCLUSION: In patients recently discharged from the hospital with the diagnosis of nonvalvular AF, warfarin use decreases and aspirin treatment increases with patients' age. These patients are older, more frequently female, and on multiple medications. The benefit of NOACs in these subjects needs to be confirmed in phase IV clinical studies. PMID: 23528931 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - March 22, 2013 Category: Internal Medicine Authors: Joppi R, Cinconze E, Mezzalira L, Pase D, Poggiani C, Rossi E, Pengo V, Italian Horizon Scanning Project Tags: Eur J Intern Med Source Type: research