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Proton pump inhibitors and the risk of cardiovascular events and cardiovascular mortality: A systematic review and meta-analysis of observational studies
CONCLUSION: It is questionable, whether PPI monotherapy constitutes a cardiovascular risk factor.PMID:36195531 | DOI:10.1016/j.ejim.2022.09.021
Source: European Journal of Internal Medicine - October 4, 2022 Category: Internal Medicine Authors: Michael Nolde Nayeon Ahn Tobias Dreischulte Evamaria Krause Florian G üntner Alexander G ünter Roman Gerlach Martin Tauscher Ute Amann Jakob Linseisen Christa Meisinger Sebastian-Edgar Baumeister Ina-Maria R ückert-Eheberg Source Type: research

Proton pump inhibitors and cardiovascular adverse effects: Real or surreal worries?
Abstract Proton pump inhibitors (PPIs) are among the most widely prescribed agents, either for treatment or prophylaxis of gastrointestinal (GI) disease, that are often administered for prolonged or chronic use. Patients with cardiovascular (CV) disease frequently receive PPIs for prophylaxis against GI bleeding due to common use of antithrombotic drugs. Over the last several years there is a growing number of reports associating chronic PPI use with a variety of serious CV and non-CV adverse effects. In this context, PPI use has been independently associated with an increased risk of CV morbidity (myocardial infa...
Source: European Journal of Internal Medicine - November 29, 2019 Category: Internal Medicine Authors: Manolis AA, Manolis TA, Melita H, Katsiki N, Manolis AS Tags: Eur J Intern Med Source Type: research

Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: Insight from the kids registry.
CONCLUSIONS: These results indicate that the use of PPIs in patients with maintenance hemodialysis might increase mortality and cardiovascular events without decreasing the risk of bleeding. Therefore, it should always be analyzed if a patient truly needs PPIs. PMID: 31735546 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - November 13, 2019 Category: Internal Medicine Authors: Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M Tags: Eur J Intern Med Source Type: research