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Valacyclovir-associated acute kidney injury and encephalopathy in an elderly woman with normal kidney function: a case report
AbstractA 72-year-old Japanese woman was treated by 3000  mg/day of valacyclovir for the herpes zoster in her left back. She had been treated as hypertension with no renal insufficiency. In two days, she visited an emergency room of a regional stroke care center with dysarthria, dexterity disorder and gait disturbance. Neither head CT nor MRI found intra cranial lesions, then, laboratory tests revealed that her serum creatinine level was 4.63 mg/dL. She was transferred and admitted to our hospital on the following day and received hemodialysis under the diagnosis of AKI due to acyclovir accompanied with encephalopathy. A...
Source: CEN Case Reports - November 18, 2022 Category: Urology & Nephrology Source Type: research

An unusual neurological syndrome in a haemodialysis patient
Nisha Jose, V Jayaprakash, A Deiva, M JayakumarIndian Journal of Nephrology 2021 31(3):293-295 Advanced age and immunosuppressed states allow for complications of herpes zoster such as encephalitis. In this case report, we describe a patient with encephalopathy two days after initiation of antiviral therapy. After the necessary imaging and cerebrospinal fluid (CSF) analysis, it became evident that the neurological syndrome was due to acyclovir. Despite currently practised renal dose modification, the patient developed acyclovir-induced neurotoxicity and required intensification of his dialysis schedule to eliminate the dr...
Source: Indian Journal of Nephrology - June 19, 2021 Category: Urology & Nephrology Authors: Nisha Jose V Jayaprakash A Deiva M Jayakumar Source Type: research