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Specialty: Primary Care
Source: Current Hypertension Reports
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Total 45 results found since Jan 2013.
Pet Ownership and the Risk of Arterial Hypertension and Cardiovascular Disease
AbstractPurpose of ReviewHypertension prevention and cardiovascular risk reduction are cornerstones in the prevention and treatment of cardiovascular diseases. Potential applicability of nontraditional cardiovascular risk reduction methods, such as pet ownership, raises a growing interest.Recent FindingsStudies show that having pets may reduce the risk of death from any cause, particularly from cardiovascular causes. Furthermore, results of some studies indicate that having pets may reduce the risk of developing hypertension and improve blood pressure control in patients with established hypertension. In addition, there is...
Source: Current Hypertension Reports - April 22, 2022 Category: Primary Care Source Type: research
Novel Targets for Hypertension Drug Discovery
AbstractPurpose of ReviewDespite the availability of various medications and prescribing combination therapies, uncontrolled blood pressure and resistance are observed in more than 40% of patients. The purpose of this review is to discuss emerging novel approaches for the treatment of hypertension and propose future research and clinical directions.Recent FindingsHypertension is a common disease of the cardiovascular system which may arise solely or as a comorbidity of other disorders. It is a crucial risk factor for cardiovascular diseases such as coronary artery disease, myocardial infarction, congestive heart failure, r...
Source: Current Hypertension Reports - March 30, 2021 Category: Primary Care Source Type: research
Blood Pressure Management in Acute Ischemic Stroke
AbstractPurpose of ReviewAbrupt blood pressure (BP) rise is the most common clinical symptom of acute ischemic stroke (AIS). However, BP alterations during AIS reflect many diverse mechanisms, both stroke-related and nonspecific epiphenomena, which change over time and across patients. While extremes of BP as well as high BP variability have been related with worse outcomes in observational studies, optimal BP management after AIS remains challenging.Recent FindingsThis review discusses the complexity of the factors linking BP changes to the clinical outcomes of patients with AIS, depending on the treatment strategy and lo...
Source: Current Hypertension Reports - December 10, 2020 Category: Primary Care Source Type: research
Multiple Gestations and Hypertensive Disorders of Pregnancy: What Do We Know?
AbstractPurpose of ReviewThe occurrence of hypertensive disorders of pregnancy (HDP) including gestational hypertension, chronic hypertension, preeclampsia, and eclampsia is proportional to the number of fetuses: singletons 6.5%, twins 12.7%, and triplets 20.0%. Literature on HDP in multifetal gestation is sparse compared with singletons. We aim to summarize the current evidence on HDP, specifically in twins.Recent FindingsHDP occurs more frequently, at an earlier gestational age, and can present more severely and atypically in twin pregnancies. HDP in twins carries a higher risk of maternal/fetal morbidity and mortality i...
Source: Current Hypertension Reports - November 18, 2020 Category: Primary Care Source Type: research
A Contemporary Approach to Hypertensive Cardiomyopathy: Reversing Left Ventricular Hypertrophy
AbstractPurpose of ReviewTo highlight pharmacological and non-pharmacological approaches to reversing hypertensive left ventricular hypertrophy (LVH). We identify high-risk phenotypes that may benefit from aggressive blood pressure (BP) management to prevent incident outcomes such as the development of atherosclerotic cardiovascular disease, stroke, and heart failure.Recent FindingsLVH is a modifiable risk factor. Intensive BP lowering (systolic BP< 120 mmHg) induces greater regression of electrocardiographic LVH than standard BP targets. The optimal agents for inducing LVH regression include renin–angiotensinogen...
Source: Current Hypertension Reports - September 4, 2020 Category: Primary Care Source Type: research
Postpartum Hypertension
AbstractPurpose of ReviewHypertension affects approximately 10% of pregnancies and may persist in the postpartum period. Furthermore, de novo hypertension may present after delivery, but its exact prevalence is not verified. Both types of hypertension expose the mother to eventually severe complications like eclampsia, stroke, pulmonary edema, and HELLP (hemolysis, elevated liver enzymes, low platelet) syndrome.Recent FindingsUntil today, there are limited data regarding the risk factors, pathogenesis, and pathophysiology of postpartum hypertensive disorders. However, there is certain evidence that preeclampsia may in larg...
Source: Current Hypertension Reports - August 5, 2020 Category: Primary Care Source Type: research
Maternal Hypertension, Advanced Doppler Haemodynamics and Therapeutic Precision: Principles and Illustrative Cases
AbstractPurpose of ReviewMaternal hypertension is a common and serious condition associated with increased maternal and foetal morbidity and mortality, with early detection and management improving outcomes.Recent FindingsBlood pressure (BP) changes of pre-eclampsia are defined after 20 gestational weeks, while haemodynamic changes can be detected at 5 –11 weeks using a specialised non-invasive Doppler stroke volume (SV) monitor. Thus, advanced haemodynamic monitoring allows for physiologically precise identification of circulatory abnormalities, and implementation of appropriate therapy within the first trimester. We m...
Source: Current Hypertension Reports - July 12, 2020 Category: Primary Care Source Type: research
Legacy Effect in the Treatment of Hypertension: Persistent Cardiovascular Protection after Conclusion of Randomized Clinical Trials in Hypertension
AbstractRecent FindingsEssential hypertension is the main determinant of cardiovascular morbidity and mortality worldwide. During the last decades, several antihypertensive drug therapies have been introduced and tested in clinical trials, both as monotherapies and combination therapies. The current recommended therapeutic approaches effectively reduce the lifetime risk of experiencing major cardiovascular outcomes and disabling comorbidities, such as myocardial infarction, stroke, and congestive heart failure. On the basis of multiple proofs, antihypertensive therapy is currently recommended for improving event-free survi...
Source: Current Hypertension Reports - October 9, 2019 Category: Primary Care Source Type: research
Sex-Specific Mechanisms in Inflammation and Hypertension
AbstractPurpose of ReviewDespite enhanced screening and therapeutic management, hypertension remains the most prevalent chronic disease in the United States and the leading cause of heart disease, chronic kidney disease, and stroke in both men and women. It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes and end organ damage. Despite known discrepancies in the risk of hypertension development between men and women, preclinical models of immune-mediated hypertension were historically developed solely in male animals, leading ...
Source: Current Hypertension Reports - May 22, 2019 Category: Primary Care Source Type: research
Revisiting the Brain Renin-Angiotensin System —Focus on Novel Therapies
AbstractPurpose of ReviewAlthough an independent brain renin-angiotensin system is often assumed to exist, evidence for this concept is weak. Most importantly, renin is lacking in the brain, and both brain angiotensinogen and angiotensin (Ang) II levels are exceptionally low. In fact, brain Ang II levels may well represent uptake of circulating Ang II via Ang II type 1 (AT1) receptors.Recent FindingsNevertheless, novel drugs are now aimed at the brain RAS, i.e., aminopeptidase A inhibitors should block Ang III formation from Ang II, and hence diminish AT1 receptor stimulation by Ang III, while AT2 and Mas receptor agonists...
Source: Current Hypertension Reports - April 3, 2019 Category: Primary Care Source Type: research
Management of “Hypertension” Based on Blood Pressure Level Versus an Absolute Cardiovascular Risk Approach
AbstractPurpose of ReviewTo address the tension between guideline recommendations and the evidence from clinical trials supporting them and clinician concerns of overtreatment of elevated blood pressure.Recent FindingsSystolic Blood Pressure Intervention trial (SPRINT) demonstrated lower blood pressure targets provided robust clinical benefit (reduced all-cause mortality) but also expected adverse events due to hypotension. Treatment thresholds for systolic blood pressure in the latest US guidelines have been lowered to 130 mmHg, although this has not been adopted elsewhere. These guidelines specify that treatment in the...
Source: Current Hypertension Reports - January 18, 2019 Category: Primary Care Source Type: research
Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening
AbstractPurpose of ReviewIncreased arterial stiffness, an abnormal structural and functional change in the vascular wall, is a precursor for hypertension, coronary heart disease, stroke, and associated cardiovascular disease (CVD). The aim of this paper is to review the etiology of arterial stiffening and potential therapeutic approaches to modulate arterial fibrosis and stiffness.Recent FindingsThe Framingham Heart Study demonstrated that arterial stiffness is an independent predictor of CVD and related morbidity and mortality. Dysfunction of endothelial cells, vascular smooth muscle cells, extracellular matrix, and other...
Source: Current Hypertension Reports - July 6, 2018 Category: Primary Care Source Type: research
Focused Update on Pharmacologic Management of Hypertensive Emergencies
AbstractPurpose of ReviewHypertensive emergency is defined as a systolic blood pressure> 180 mmHg or a diastolic blood pressure> 120 mmHg with evidence of new or progressive end-organ damage. The purpose of this paper is to review advances in the treatment of hypertensive emergencies within the last 5 years.Recent FindingsNew literature and recommendations for managing hypertensive emergencies in the setting of pregnancy, stroke, and heart failure have been published.SummaryOral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenti...
Source: Current Hypertension Reports - June 8, 2018 Category: Primary Care Source Type: research
Blood Pressure Goals in Acute Stroke —How Low Do You Go?
AbstractPurpose of ReviewElevations in systolic blood pressure (BP) greater than 140 mmHg are reported in the majority (75%) of patients with acute ischemic stroke and in 80% of patients with acute intracerebral hemorrhages (ICH). This paper summarizes and updates the current knowledge regarding the proper management strategy for elevated BP in patients with acute stroke.Recent Findings and SummaryRecent studies have generally showed a neutral effect of BP reduction on clinical outcomes among acute ischemic stroke patients. Thus, because of the lack of convincing evidence from clinical trials, aggressive BP reduction in ...
Source: Current Hypertension Reports - April 10, 2018 Category: Primary Care Source Type: research
