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Recognition, identification, and diagnosis announcement of neonatal arterial ischemic stroke: A combined exploratory quantitative and qualitative study on parents' lived experiences
CONCLUSION: Maternity hospital caregivers' awareness of NAIS is crucial to reach early diagnosis. Improving this aspect would not only allow better early management, but also make it possible to set up acute neuroprotective strategies. Clinicians should be attentive to the modalities of diagnosis and prognosis announcements, which are associated with considerable stress and misconceptions.PMID:33715932 | DOI:10.1016/j.arcped.2021.02.002
Source: Archives de Pediatrie - March 15, 2021 Category: Pediatrics Authors: Cindy Leal Martins St éphane Chabrier Joel Fluss Source Type: research

Psoriasis and metabolic and cardiovascular comorbidities in children: A systematic review.
CONCLUSION: This systematic review suggests that psoriasis in children is not associated with metabolic and cardiovascular comorbidities, except overweight and obesity, for which higher prevalence is clearly demonstrated in the literature. PMID: 30638928 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - January 10, 2019 Category: Pediatrics Authors: Badaoui A, Tounian P, Mahé E Tags: Arch Pediatr Source Type: research

Childhood arterial ischemic stroke in Senegal (West Africa).
Abstract Etiological factors of childhood ischemic stroke depend on the epidemiological context. The purpose of this study was to determine the risk factors, the clinical and radiologic features, and the outcome of arterial ischemic stroke in a case series of Senegalese children. We carried out a retrospective registry-based study on arterial ischemic stroke in children hospitalized in the neurology department of Fann Teaching Hospital and Albert Royer Children's Hospital, from January 2005 to December 2015. We enrolled 116 cases with an age range from 2 months to 18 years. The mean age at stroke occurrence was 71...
Source: Archives de Pediatrie - August 21, 2018 Category: Pediatrics Authors: Ndiaye M, Lengue F, Sagna SD, Sow AD, Fogany Y, Deme H, Basse AM, Diop-Sene MS, Diagne NS, Diop AG, Ndiaye O, Ndiaye MM Tags: Arch Pediatr Source Type: research

Cerebral vasculopathy in children with sickle cell disease: Key issues and the latest data.
Abstract Cerebral vasculopathy is a common and severe complication of sickle cell disease in children. The pathophysiology consists of progressive damage to the basal intracranial arteries and cerebral microcirculation, while chronic anemia worsens exposure to cerebral hypoxia. It results in stroke and subclinical or poorly symptomatic ischemic lesions. Many clinical, biological, and radiological risk factors have been identified. The prevention strategy through systematic transcranial Doppler screening of large-vessel vasculopathy has revolutionized the management of this disease and has greatly decreased the ris...
Source: Archives de Pediatrie - December 15, 2017 Category: Pediatrics Authors: Corvest V, Blais S, Dahmani B, De Tersant M, Etienney AC, Maroni A, Ormières C, Roussel A, Pondarré C Tags: Arch Pediatr Source Type: research

Acute methotrexate-related neurotoxicity and pseudo-stroke syndrome.
We describe five episodes of transient acute leukoencephalopathy mimicking a stroke, reported in the literature as "pseudo-stroke syndrome". Neurologic symptoms occurred 3-10 days after IV or IT methotrexate and manifested as aphasia and alternating sensorimotor deficit. The fluctuating symptomatology regressed completely within a few days. Brain MRI, which is essential for diagnosis, demonstrated early white matter diffusion restriction in the affected cerebral area. These anomalies disappeared in one week, while hyperintense T2 FLAIR signals developed in the corresponding brain areas. The long-term progression of thes...
Source: Archives de Pediatrie - November 13, 2017 Category: Pediatrics Authors: Deneux V, Leboucq N, Saumet L, Haouy S, Akbaraly T, Sirvent N Tags: Arch Pediatr Source Type: research

Brain plasticity and early rehabilitative care for children after neonatal arterial cerebral infarction.
Abstract Currently, in the literature of the evidence based medicine, little data are available to confirm the benefit and the specific procedures of an early intervention for a neonatal arterial ischemic stroke. However, data about the effect of an early physical rehabilitation program on the cerebral plasticity, and preliminary results of clinical studies in children with cerebral palsy strongly suggest the benefit of an early rehabilitation with a multidisciplinary approach. The type of the rehabilitation and its frequency must be determined because a wide variability in the practices exists. A comprehensive ca...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Dinomais M, Marret S, Vuillerot C Tags: Arch Pediatr Source Type: research

Long term outcome of perinatal stroke.
Abstract Neonatal Arterial Ischemic Stroke (NAIS) affects 6-17 newborns on 100 000-birth term neonates, most of these children keeping long-term motor and cognitive impairments. Based on a literature review, the objectives of this paper are to describe motor and cognitive outcomes after a NAIS and to propose a consensual monitoring of these children to improve their management. About 30 % of children after a NAIS will develop a unilateral cerebral palsy requiring a management by a team with expertise in physical medicine and rehabilitation. Unlike adults, especially after a left NAIS, children will not present aph...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Vuillerot C, Marret S, Dinomais M Tags: Arch Pediatr Source Type: research

Therapeutic management of neonatal arterial cerebral infarction and neuroprotection perspectives.
Abstract Neonatal seizure related to stroke is a common diagnostic feature. Their treatment, although widely debated even today must be initiated in case of status epilepticus, clinical seizures of more than 5 minutes duration or short (> 30 secondes) and repeated clinical seizures (2 or more per hour). The treatment of neonatal seizures is a challenge that remains only partially solved. It should take into account the etiology of seizures, type of brain lesions and clinical/electrical response to treatment after the first line treatment. It is based on using a single anti-epileptic at its maximum dosage, and i...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Baud O, Auvin S, Saliba E, Biran V Tags: Arch Pediatr Source Type: research

Place of EEG in the management of arterial ischemic stroke newborn.
Abstract The EEG has a key role in the management of neonatal seizures, which are the typical mode of revelation of neonatal ischemic stroke. The EEG should be started as soon as possible in case of suspected seizure. Some EEG features are evocative of neonatal stroke, typically asymmetry of background activity with the presence of focal spikes and focal seizures. The EEG should be prolonged and always associated with a video as pauci-symptomatic or subclinical seizures are frequent, including some status epilepticus. Video-EEG monitoring is therefore essential to judge the efficacy of anticonvulsant therapy. Ther...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Nguyen The Tich S Tags: Arch Pediatr Source Type: research

Biological monitoring and other explorations in the acute phase of a neonatal arterial ischemic stroke (excluding hemostasis).
Abstract Neonatal monitoring and other explorations required just after neonatal arterial ischemic stroke (NAIS) diagnosis remain elusive. This review attempts to propose guidelines on this topic. During neonatal period, three major contexts related to NAIS emerge: 1) Metabolic disorders including hypoglycemia; 2) Early post-natal infections; 3) Cardio-vascular anomalies. Different patient profiles have been defined (typical, atypical and at risk profiles). According to these profiles, a final decisional tree including biological monitoring and complementary explorations has been suggested to caregivers. PMID...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Favrais G, Nguyen The Tich S Tags: Arch Pediatr Source Type: research

Neonatal arterial ischemic stroke in term or near-term newborns: prevalence and risk factors.
Abstract The general designation ischemic perinatal stroke includes several disease states that differ in pathophysiology, timing of occurrence and presentation. While it seems logical to assume that their prevalence and their risk factors depend primarily on the considered type of stroke, most studies used inconsistent definitions or included heterogeneous populations, which limits their accuracy. Given these biases, the French Society of Neonatology and the French Centre for Paediatric Stroke wished to update the knowledge in this domain, focusing on a specific form of perinatal stroke, i.e neonatal arterial isc...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Darmency-Stamboul V, Cordier AG, Chabrier S Tags: Arch Pediatr Source Type: research

Neonatal arterial ischemic stroke: Which thrombotic biological risk factors to investigate and which practical consequences?
Abstract All biological risk factors that have been previously identified to increase the risk of thrombosis in adults, have also been studied in neonates with arterial Ischemic Stroke (NAIS), but most studies were retrospective and included relatively low numbers of affected children. We therefore could not suggest recommendations with a strong level of evidence and only expert proposals potentially useful for clinical practice will be presented in this text. Despite these limitations, the extensive analysis of published data supported that factor V Leiden (FVL) and increased levels of Lp(a) could be significant ...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Perez T, Valentin JB, Saliba E, Gruel Y Tags: Arch Pediatr Source Type: research

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