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Compartmentalization of Immune Responses during Staphylococcus aureus Cranial Bone Flap Infection.
Abstract Decompressive craniectomy is often required after head trauma, stroke, or cranial bleeding to control subsequent brain swelling and prevent death. The infection rate after cranial bone flap replacement ranges from 0.8% to 15%, with an alarming frequency caused by methicillin-resistant Staphylococcus aureus, which is problematic because of its recalcitrance to antibiotic therapy. Herein we report the establishment of a novel mouse model of S. aureus cranial bone flap infection that mimics several aspects of human disease. Bacteria colonized bone flaps for up to 4 months after infection, as revealed by scan...
Source: The American Journal of Pathology - June 6, 2013 Category: Pathology Authors: Cheatle J, Aldrich A, Thorell WE, Boska MD, Kielian T Tags: Am J Pathol Source Type: research