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Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population
This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.RESUMEN La interleucina-4 (IL-4) tiene gran importancia en los procesos inflamatorios en casos de accidente cerebrovascular (ACV), puesto que hace que las microgl ías sean polarizadas hacia el fe...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

Association of the CHGA gene polymorphism in patients with hemorrhagic stroke and/or aneurysm
Conclusion: The Glu264Asp CHGA polymorphism does not seem to contribute to the genesis of the CHGA protein expression in this patients group, but to understand whether or not there is a possible association of the pathology in question and whether the mutation will contribute in the gene therapy and thus to improve patients ’ quality of life.RESUMEN Introducci ón: Enfermedades cerebrovasculares han sido vinculadas a diversos genes. La cromogranina A (CgA) es utilizada como un marcador en enfermedades cardiovasculares. Por consiguiente, evaluar el polimorfismo y verificar la asociación con esa patología es muy importan...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Quantitation of muscle pathology abnormalities in 18 patients with mitochondrial disorders
CONCLUSION: Pathologic events, groupe d in ascending order of frequency, were RRFs, SDH+ fibers, COX- fibers, and COMBO+ fibers. These data emphasize the importance of the COMBO technique in revealing occult COX deficiency in muscle fibers.RESUMO INTRODU ÇÃO: Desordens mitocondriais são usualmente caracterizadas por: 1. acúmulo de mitocôndria nas fibras musculares que aparecem como fibras vermelhas rasgadas (FVR) ou azuis rasgadas quando coradas, respectivamente, pelo tricrômio modificado de Gomori ou pelo succinato desidrogenase (SDH+); 2. au sência de atividade da citocromo c oxidase (COX), originando fibras COX n...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - December 12, 2018 Category: Pathology Source Type: research

Apolipoprotein E and PAI-1 gene polymorphisms and no association with arterial ischemic stroke and peripheral arterial disease manifestations
Conclusion: No significant difference was observed by comparing patients and controls. In this study, no association was found between the presence of the evaluated polymorphisms and the occurrence of thrombotic events.RESUMO Introdu ção: A trombose arterial é considerada uma doença multifatorial, resultante da interação de fatores de risco genéticos e adquiridos. Objetivos: O objetivo deste estudo foi investigar a presença dos polimorfismos nos genes do inibidor da ativação do plasminogênio tipo 1 (PAI-1) e da apoli poproteína E (ApoE), bem como suas interações com níveis de PAI-1 e lipídios e perfis de ap...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 13, 2018 Category: Pathology Source Type: research

TNFA gene in Brazilian patients with hemorrhagic stroke or cerebral aneurysm
Conclusion: The TNFA -308 AG genotype is associated with a decreased risk of aneurysm or hemorrhagic stroke in a population from the capital of Brazil, Distrito Federal.RESUMO Introdu ção: Muitas doenças cerebrovasculares relacionam-se com processos inflamatórios, portanto, a influência de vários polimorfismos em doenças tem sido estudada para melhorar o conhecimento sobre os mecanismos fisiológicos do sistema nervoso. Objetivo: Identificar a associação entre um polimo rfismo na posição -308 do gene TNFA e o desenvolvimento de acidente vascular encefálico hemorrágico (AVEH) ou aneurisma em pacientes de uma ba...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 13, 2018 Category: Pathology Source Type: research