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Efficacy and safety of odanacatib for osteoporosis treatment: a systematic review and meta-analysis
ConclusionODN is an appealing long-term osteoporosis treatment method; however, further research should focus on the potential increased risk of fracture and stroke.
Source: Archives of Orthopaedic and Trauma Surgery - May 11, 2023 Category: Orthopaedics Source Type: research

Osteoporotic fracture admissions compared to other major medical admissions in Irish public hospitals
ConclusionOsteoporotic fractures represent a large and rapidly increasing illness burden amongst older Irish adults, with substantial care requirements and the resulting onus on our healthcare system. Urgent action is needed to address this public health issue and the services for those at risk of fracture.
Source: Archives of Orthopaedic and Trauma Surgery - December 17, 2022 Category: Orthopaedics Source Type: research

Anemia is associated with increased risk of non-vertebral osteoporotic fractures in elderly men: the MrOS Sweden cohort
ConclusionsAnemia is associated with an increased risk for any fracture and non-vertebral osteoporotic fracture in elderly men with a long follow-up time. The cause is probably multifactorial and our results support that anemia can be used as a predictor for future fracture.
Source: Archives of Orthopaedic and Trauma Surgery - June 23, 2022 Category: Orthopaedics Source Type: research

Fragility fractures in Europe: burden, management and opportunities
ConclusionsFracture-related burden is expected to increase over the coming decades. Given the substantial treatment gap and proven cost-effectiveness of fracture prevention schemes such as fracture liaison services, urgent action is needed to ensure that all individuals at high risk of fragility fracture are appropriately assessed and treated.
Source: Archives of Orthopaedic and Trauma Surgery - April 18, 2020 Category: Orthopaedics Source Type: research

Weight loss since early adulthood, later life risk of fracture hospitalizations, and bone mineral density: a prospective cohort study of 0.5 million Chinese adults
ConclusionsWeight loss from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life.
Source: Archives of Orthopaedic and Trauma Surgery - April 18, 2020 Category: Orthopaedics Source Type: research

No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis
ConclusionsThe anti-Rank ligand and PTH analogs have no impact on cardiovascular risk and overall mortality in idiopathic osteoporosis. To better answer the question whether these treatments can reduce the long-term cardiovascular risk, further comparative studies with longer duration are required.
Source: Archives of Orthopaedic and Trauma Surgery - January 2, 2020 Category: Orthopaedics Source Type: research

Incidence and risk factors of medical complications and direct medical costs after osteoporotic fracture among patients in China
ConclusionsOsteoporotic fractures led to amount of medical complications, which significantly increased patients ’ economic burden. Complications correlate to various factors such as patients’ disease history.
Source: Archives of Orthopaedic and Trauma Surgery - February 27, 2018 Category: Orthopaedics Source Type: research

Upright activity and higher motor function may preserve bone mineral density within 6  months of stroke: a longitudinal study
ConclusionBetter motor control and walking recovery were associated with reduced bone loss. Interventions targeting these impairments from early post-stroke are warranted.Clinical trial registrationURL:http://www.anzctr.org.au. Unique identifier: ACTRN12612000123842.
Source: Archives of Orthopaedic and Trauma Surgery - January 8, 2018 Category: Orthopaedics Source Type: research

Association of stroke subtypes with risk of hip fracture: a population-based study in Taiwan
ConclusionOverall, stroke significantly increases the incidence of HF, and the risk of HF is significantly higher in ICH patients and female gender. We should identify stroke patients at risk of HF and pay more attention to prevent them from fall in poststroke long-term care.
Source: Archives of Orthopaedic and Trauma Surgery - November 22, 2017 Category: Orthopaedics Source Type: research

Mortality following benign sacral insufficiency fracture and associated risk factors
ConclusionsLike other types of osteoporotic fractures, sacral insufficiency fractures are associated with increased mortality.
Source: Archives of Orthopaedic and Trauma Surgery - November 9, 2017 Category: Orthopaedics Source Type: research