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Specialty: Neurology
Source: International Journal of Stroke
Therapy: Thrombolytic Therapy
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Total 18 results found since Jan 2013.
Heart rate variability and baroreceptor sensitivity in acute stroke: a systematic review
BackgroundAutonomic nervous system dysfunction is common after acute stroke and is associated with elevated risk of cardiac arrhythmia and mortality. Heart rate variability and baroreceptor sensitivity have been investigated as parameters of autonomic nervous system dysfunction for the prediction of stroke outcome.
SummaryWe performed a systematic literature review on heart rate variability and baroreceptor sensitivity as parameters for autonomic nervous function in acute stroke. Twenty‐two studies were included. Associations between heart rate variability or baroreceptor sensitivity and stroke severity, early and late c...
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Laetitia Yperzeele, Robbert‐Jan van Hooff, Guy Nagels, Ann De Smedt, Jacques De Keyser, Raf Brouns Tags: Systematic review Source Type: research
Burden of stroke in Italy: An economic model highlights savings arising from reduced disability following thrombolysis
ConclusionOur study reveals that performing thrombolytic therapy in eligible patients improves economic outcomes compared with patients receiving standard care. This model is useful for decision makers, both within and outside of the Italian national context, as a tool to assess the cost‐effectiveness of thrombolysis in both short‐ and long‐term period.
Source: International Journal of Stroke - April 8, 2015 Category: Neurology Authors: M. Chiumente, M. M. Gianino, D. Minniti, T. J. Mattei, B. Spass, K. M. Kamal, D. E. Zimmerman, A. Muca, E. Luda Tags: Research Source Type: research
Symptomatic intracranial hemorrhage in the ALIAS Multicenter Trial: relationship to endovascular thrombolytic therapy
ConclusionsEndovascular thrombolysis was the major factor predisposing to symptomatic intracranial hemorrhage, and albumin contributed to this predisposition. The latter may be mediated by albumin's influence on platelet aggregation or collateral perfusion.
Source: International Journal of Stroke - March 22, 2015 Category: Neurology Authors: Myron D. Ginsberg, Michael D. Hill Tags: Research Source Type: research
Should minor stroke patients be thrombolyzed? A focused review and future directions
Stroke is a leading cause of morbidity and mortality worldwide. Up to 80% of ischemic stroke patients may initially present with minor symptoms. Minor stroke and transient ischemic attack patients are typically treated conservatively with antiplatelet agents and general vascular prevention strategies. Yet a high proportion develop recurrent stroke or progression of stroke and up to one in four of these patients are disabled or dead at follow‐up. Minor or rapidly improving symptoms are the top reasons for withholding thrombolytic therapy to time‐eligible stroke patients as they are believed to be ‘too good to treat’...
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Amy Y. X. Yu, Michael D. Hill, Shelagh B. Coutts Tags: Review (invited) Source Type: research
Decompressive craniectomy for stroke after intravenous thrombolytic therapy
Source: International Journal of Stroke - November 10, 2014 Category: Neurology Authors: Bruno Barroso Tags: Letter to the editor Source Type: research
World Stroke Organization Global Stroke Services Guidelines and Action Plan
Every two seconds, someone across the globe suffers a symptomatic stroke. ‘Silent’ cerebrovascular disease insidiously contributes to worldwide disability by causing cognitive impairment in the elderly. The risk of cerebrovascular disease is disproportionately higher in low to middle income countries where there may be barriers to stroke care. The last two decades have seen a major transformation in the stroke field with the emergence of evidence‐based approaches to stroke prevention, acute stroke management, and stroke recovery. The current challenge lies in implementing these interventions, particularly in regions ...
Source: International Journal of Stroke - September 23, 2014 Category: Neurology Authors: Patrice Lindsay, Karen L. Furie, Stephen M. Davis, Geoffrey A. Donnan, Bo Norrving Tags: Guidelines Source Type: research
Prehospital factors determining regional variation in thrombolytic therapy in acute ischemic stroke
ConclusionsThese results suggest that the larger proportion of patients arriving within 4·5 h in the centralized model might be related to a lower threshold to use emergency services to transport stroke patients and partly to preferential referral of thrombolysis candidates.
Source: International Journal of Stroke - December 23, 2013 Category: Neurology Authors: Maarten M. H. Lahr, Patrick C. A. J. Vroomen, Gert‐Jan Luijckx, Durk‐Jouke Zee, Ronald Vos, Erik Buskens Tags: Research Source Type: research
The impact of cerebrovascular disease in Panama
ConclusionSince 2013, both hospitals' intravenous thrombolytic therapy program has been successfully applied as public health policy. A successful campaign on healthy lifestyle must be strengthened through a comprehensive approach with other public sectors in order to have an impact on the population, particularly in children and adolescents.
Source: International Journal of Stroke - November 21, 2013 Category: Neurology Authors: Fernando Gracia, Aron Benzadon, Marco Gonzalez‐Castellon, Blas Armien Tags: Research Source Type: research
Body mass index and acute ischemic stroke outcomes
ConclusionsBeing overweight or obese is associated with a better functional outcome and reduced mortality in patients of acute ischemic stroke. However, the definition of an ‘optimal’ body mass index, in relation to stroke outcomes, may be affected by age, gender, and use of thrombolytic therapy.
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: M. Saini, M. Saqqur, A. Shuaib, Tags: Research Source Type: research
Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
ConclusionsThese results do not suggest a differential response to tissue plasminogen activator based on race ethnicity. Among Asians, data were particularly sparse, and results should be interpreted with caution.
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Nishant K. Mishra, Pitchaiah Mandava, Christopher Chen, James Grotta, Kennedy R. Lees, Thomas A. Kent, Tags: Research Source Type: research
Translational perspectives on perfusion–diffusion mismatch in ischemic stroke
Magnetic resonance imaging has tremendous potential to illuminate ischemic stroke pathophysiology and guide rational treatment decisions. Clinical applications to date have been largely limited to trials. However, recent analyses of the major clinical studies have led to refinements in selection criteria and improved understanding of the potential implications for the risk vs. benefit of thrombolytic therapy. In parallel, preclinical studies have provided complementary information on the evolution of stroke that is difficult to obtain in humans due to the requirement for continuous or repeated imaging and pathological veri...
Source: International Journal of Stroke - October 1, 2013 Category: Neurology Authors: Bruce C. V. Campbell, I. Mhairi Macrae Tags: Review Source Type: research
Predictors of in‐hospital death and symptomatic intracranial hemorrhage in patients with acute ischemic stroke treated with thrombolytic therapy: Paul Coverdell Acute Stroke Registry 2008–2012
ConclusionsIn this study of acute ischemic stroke patients, older age, male gender, National Institutes of Health Stroke Scale score, history of myocardial infarction or coronary artery disease, and history of atrial fibrillation were associated with increased in‐hospital death among patients receiving intravenous tissue plasminogen activator. Among patients treated with intravenous tissue plasminogen activator, in‐hospital mortality and symptomatic intracerebral hemorrhage rates were similar between those treated within three‐hours of time last known to be well and those treated between three and 4·5 hours after this time.
Source: International Journal of Stroke - September 12, 2013 Category: Neurology Authors: Xin Tong, Mary G. George, Quanhe Yang, Cathleen Gillespie Tags: Research Source Type: research
Intravenous thrombolytic therapy for acute ischemic stroke in Tuzla Canton, Bosnia and Herzegovina
Source: International Journal of Stroke - September 11, 2013 Category: Neurology Authors: Dževdet Smajlović, Denisa Salihović, Leila Avdić, Zikrija Dostović, Omer Ć. Ibrahimagić, Mirjana Vidović Tags: Letter to the editor Source Type: research
A multicenter, randomized, double‐blinded, placebo‐controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III)
BackgroundIn adults, intraventricular thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) facilitates resolution of intraventricular haemorrhage (IVH), reduces intracranial pressure, decreases duration of cerebrospinal fluid diversion, and may ameliorate direct neural injury. We hypothesize that patients with small parenchymal haematoma volumes (<30 cc) and relatively large IVH causing acute obstructive hydrocephalus would have improved clinical outcomes when given injections of low‐dose rtPA to accelerate lysis and evacuation of IVH compared with placebo.
MethodsThe Clot Lysis Evaluation of Ac...
Source: International Journal of Stroke - August 1, 2013 Category: Neurology Authors: Wendy C. Ziai, Stanley Tuhrim, Karen Lane, Nichol McBee, Kennedy Lees, Jesse Dawson, Kenneth Butcher, Paul Vespa, David W. Wright, Penelope M. Keyl, A. David Mendelow, Carlos Kase, Christine Wijman, Marc Lapointe, Sayona John, Richard Thompson, Carol Thom Tags: Research Source Type: research
What are the most important barriers for thrombolytic therapy in ischemic stroke patients?
Source: International Journal of Stroke - May 20, 2013 Category: Neurology Authors: Hormoz Ayromlou, Hassan Soleimanpour, Mehdi Farhoudi, Elyar Sadeghi‐Hokmabadi, Rouzbeh Rajaei Ghafouri, Ehsan Sharifipour, Somayeh Mostafaei, Mehdi Najafi Nashali Tags: Letter to the editor Source Type: research
