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Cerebral blood flow evaluation of intensive rosuvastatin therapy in stroke/transient ischemic attack patients with intracranial arterial atherosclerotic stenosis study: Rationale  and design
ConclusionThe CEIRIS trial about the effects of statin on the temporal hemodynamic progression of ICAS may extend our understanding of the basic pathophysiology and mechanisms of stroke in ICAS patients. With the use of computed tomography perfusion, we aim to evaluate the impact of Rosuvastatin on cerebral hemodynamic changes, as well as the downstream perfusion. This trial concerning the effects of statin on the temporal hemodynamic progression of intracranial atherosclerotic stenosis (ICAS) may extend our understanding of the basic pathophysiology and mechanisms of stroke in ICAS patients.
Source: Brain and Behavior - April 1, 2017 Category: Neurology Authors: Xuting Zhang, Ying Zhou, Sheng Zhang, Wenhong Ding, Min Lou Tags: METHODS Source Type: research

Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy
ConclusionsTaking statins prior to CEA did not seem to affect the risk of major perioperative ischemic events and death, most likely due to the extremely low overall incidence of perioperative complications. Recent reports have shown that the preoperative use of statins has a protective role after noncardiac vascular and cardiac surgery, attenuating the perioperative incidence of stroke, myocardial infarction, and death. Only few studies, however, have investigated on the benefit of statin use in patients undergoing carotid endarterectomy for severe carotid disease, reporting variable results. Findings from our study show...
Source: Brain and Behavior - September 30, 2016 Category: Neurology Authors: Enzo Ballotta, Antonio Toniato, Filippo Farina, Claudio Baracchini Tags: Original Research Source Type: research

U ‐curve relation between cholesterol and prior ischemic stroke
ConclusionOur hypothesis was falsified. The association between lower cholesterol levels and higher frequency of prior ischemic stroke in patients with cholesterol <5.5 mmol/L cannot be solely an effect of aggressive statin treatment in patients with prior ischemic stroke, as the association pertained also to patients who did not use statin. Previous studies on ischemic stroke patients have shown conflicting results concerning the association between cholesterol level and patient outcome. We hypothesized that acute ischemic stroke patients with increased cholesterol on admission more frequently had experienced prior i...
Source: Brain and Behavior - August 31, 2016 Category: Neurology Authors: Gerd Haga Bringeland, Aliona Nacu, Ulrike Waje ‐Andreassen, Lars Thomassen, Halvor Naess Tags: Original Research Source Type: research

Statin use after intracerebral hemorrhage: a 10 ‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - May 12, 2016 Category: Neurology Authors: Shu ‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research

Statin use after intracerebral hemorrhage: a 10‐year nationwide cohort study
ConclusionHydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on recurrent ICH or other components of the composite outcome. Additional studies are required to clarify the biological mechanisms underlying these observations. Statin therapy has demonstrated benefits in ischemic stroke patients, but statin use and intracerebral hemorrhage (ICH) remain a concern. Hydrophilic statin therapy is associated with a reduced risk of recurrent ICH in post‐ICH patients. The intensity of statin use had no significant effect on rec...
Source: Brain and Behavior - March 31, 2016 Category: Neurology Authors: Shu‐Yu Tai, Feng‐Cheng Lin, Chung‐Yin Lee, Chai‐Jan Chang, Ming‐Tsang Wu, Chen‐Yu Chien Tags: Original Research Source Type: research