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Use of Diterpene Ginkgolides Meglumine Injection to Regulate Plasma Levels of PAI-1 and t-PA in Patients With Acute Atherosclerotic Cerebral Infarction
Background: To: (i) explore the effect of diterpene ginkgolides meglumine injection (DGMI) on neurological deficit symptoms in acute atherosclerotic cerebral infarction (AACI) patients; (ii) measure the level of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA). Methods: Eighty AACI patients were divided equally and randomly into the DGMI group and control group. In addition to basic treatment, the DGMI group was treated with DGMI (25 mg/d) for 14 days. The control group had basic treatment without DGMI. Before and after treatment, the degree of neurological deficit was ass...
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Posterior Circulation Alberta Stroke Program Early Computed Tomography Score (pc-ASPECT) for the Evaluation of Cerebellar Infarcts
Background: Patients with cerebellar ischemic stroke may be misdiagnosed and may exhibit a delayed time to acute stroke treatment compared with patients with anterior circulation ischemic stroke. The posterior circulation Alberta stroke program early computed tomography score (pc-ASPECT) score has been used to evaluate hyperacute stroke, much as the ASPECT in anterior circulation stroke recently. Our main objective was to evaluate the associations of the clinical and etiological characteristics of ischemic cerebellar infarction patients on admission with their pc-ASPECT scores, as well as the correlations of the pc-ASP...
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

The Relation of End-Tidal CO2 Values With Infarct Volume and Early Prognosis in Patients With Acute Ischemic Stroke
Conclusions: This study highlights the importance of capnography follow-up of patients with acute ischemic stroke. In patients with acute ischemic stroke, the EtCO2 value measured at the time of admission is lower in the group with high mRS at both admission and discharge.
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Association Between Cerebral Autoregulation and Long-Term Outcome in Patients With Acute Ischemic Stroke
Background: Dynamic cerebral autoregulation (CA) is known to be impaired in patients with acute ischemic stroke (AIS), but whether or not dynamic CA can predict long-term outcomes is unclear. Materials and Methods: This prospective study included 103 patients with AIS between September 2017 and April 2019. We measured the middle cerebral artery blood flow velocity and blood pressure within 7 days of AIS onset using a transcranial Doppler and Finometer, respectively. We conducted transfer function analysis to calculate dynamic CA indices (phase and gain), with lower phase and higher gain parameters reflecting les...
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Are We Aware of the Neurological Manifestations of Cytomegalovirus Infection in Immunocompetent Individuals?
Conclusion: CMV infection should be considered in the differential diagnosis of patients presenting with neurological symptoms, even among immunocompetent individuals, because of the high possibility that patients can greatly benefit from antiviral treatment at the early stage.
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Hidden Telltale Signs in Hyperacute Ischemic Stroke Caused by Aortic Dissection: A Case Report and Post Hoc Analysis
Conclusion: Hyperacute ischemic stroke caused by AD often hides some telltale signs. Clinicians should master basic clinical skills to exclude AD by looking for these telltale signs hidden in hyperacute ischemic stroke to avoid the fatal consequences of intravenous thrombolysis and/or cerebral angiography within the narrow window of time.
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Major Neurological Deficit Following Neck Hyperextension During Dental Treatment: Report of 2 Cases and Review of the Literature
Conclusions: Pathogenesis, as well as predisposing factors, are discussed, and new terminology is established as a means to encourage research on this rare complication of neck positioning on dental chairs.
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Relationship Between Carotid Artery Angle and Plaque Morphology in Acute Cerebral Infarction Patients
Conclusions: In this study, CA morphology in acute stroke patients is not associated with plaque volume or composition, but age and nonplanar ICAA can predict left carotid plaque volume.
Source: The Neurologist - September 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

A Stroke Alert With Unexpected Outcome
Conclusion: We report a case of thrombolysis administered in a patient with high-grade glioma with no apparent complications.
Source: The Neurologist - September 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

The Relationship Between Renal Function and Imaging Markers and Total Burden of Cerebral Small Vessel Disease
Conclusion: Our results indicate that there is a relationship between renal function impairment and increased total burden, as well as acute ischemic stroke/transient ischemic attack due to small vessel occlusion.
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Association of Changed Serum Brain Biomarkers With Perihematomal Edema and Early Clinical Outcome in Primary ICH Patients
Background: Perihematomal edema (PHE) following primary intracranial hemorrhages (ICHs) affects the patient outcome. Also, serum biomarkers such as S100 calcium-binding protein B (S100B) and glial fibrillary acidic protein (GFAP) have been associated with ICHs outcome. We aimed to investigate the association between these biomarkers and PHE in ICH patients. Methods: In this cross-sectional study, patients with primary ICH between January 2020 and August 2020 were evaluated. All participants underwent spiral brain computed tomography scans upon admission, and 48 to 72 hours later and quantification of initial hem...
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation as Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis
Background: Previous studies showed that the application of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) during stroke rehabilitation improve the depression symptoms in poststroke depression (PSD). However, some studies showed inconsistent results. The study was designed to make a meta-analysis to evaluate the effect of noninvasive brain stimulation (tDCS and rTMS) on PSD. Methods: Articles published before July 2021 were searched in databases: PubMed, Web of Science, and Google Scholar. STATA 12.0 software was utilized to make meta-analysis. We extracted...
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Trigger Point Injection as a Rare Cause of Ischemic Stroke: A Case Report
Conclusion: The reported patient is the first in the literature who suffered from ischemic stroke after TPI. The use of ultrasound for injections into the neck muscles could avoid serious complications.
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Artery of Percheron Occlusion in China: A Case Report and Chinese Literature Review
Conclusion: Our report suggests that unusual mood disorder and language disorder of aged patients might indicate the AOP occlusion, and cerebral imaging of magnetic resonance imaging (better with magnetic resonance angiography) should be performed to establish the diagnosis of AOP occlusion. The fast and accurate diagnosis of stroke because of AOP occlusion could best benefit the patients.
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Large Middle Cerebral Artery Ischemic Stroke in a Therapeutically Anticoagulated Patient With Severe SARS-CoV-2 Infection
Introduction: Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with hypercoagulability which can predispose infected patients to both arterial and venous thromboembolic complications. Despite therapeutic anticoagulation, there remains a risk of ischemic strokes, which may lead to adverse patient outcomes. Only a few cases are described in the literature regarding SARS-CoV-2 positive patients developing thrombotic ischemic strokes despite therapeutic anticoagulation. Case Report: The following is a case discussion regarding a 71-year-old female with pas...
Source: The Neurologist - July 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

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