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A Kinematic Study of Progressive Micrographia in Parkinson's Disease
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of <10 years and 24 age-matched controls wrote the letter “e” repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson's Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last fi...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference
Source: Annals of Neurology - September 23, 2014 Category: Neurology Authors: Beth‐Anne Sieber, Story Landis, Walter Koroshetz, Randall Bateman, Andrew Siderowf, Wendy R. Galpern, John Dunlop, Steven Finkbeiner, Margaret Sutherland, Hao Wang, Virginia M.‐Y. Lee, Harry T. Orr, Katrina Gwinn, Kip Ludwig, Anna Taylor, Christine To Tags: Editorial Source Type: research

Recommendations of the Alzheimer's Disease-Related Dementias Conference
The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer disease includes not only Alzheimer disease (AD) proper, but also several specified related dementias, namely, frontotemporal, Lewy body, vascular, and mixed dementia. In response to a specific action item in the 2012 National Plan, the National Institute of Neurological Disorders and Stroke, in collaboration with the National Institute on Aging, convened panels of experts and conducted a 2-day public conference to develop research priorities and ti...
Source: Neurology - August 25, 2014 Category: Neurology Authors: Montine, T. J., Koroshetz, W. J., Babcock, D., Dickson, D. W., Galpern, W. R., Glymour, M. M., Greenberg, S. M., Hutton, M. L., Knopman, D. S., Kuzmichev, A. N., Manly, J. J., Marder, K. S., Miller, B. L., Phelps, C. H., Seeley, W. W., Sieber, B.-A., Silv Tags: All Cognitive Disorders/Dementia, Alzheimer's disease, Frontotemporal dementia, Parkinson's disease with dementia, Vascular dementia VIEWS & amp;amp; REVIEWS Source Type: research