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Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats*
Methamphetamine is a potent psychostimulant drug which has been gaining popularity worldwide (United Nations Office on Drugs and Crime, 2009). From a pathological standpoint, chronic methamphetamine abuse has devastating effects on the neural system and predisposes people to movement disorders, stroke, seizures, aggressiveness, memory deficits, and psychosis (Hsieh et al., 2014; Panenka et al., 2013; Yamamoto et al., 2010). These changes can remain for years after discontinued use and may reflect risk factors for relapse (Grant et al., 2012; Scott et al., 2007).
Source: Drug and Alcohol Dependence - April 29, 2015 Category: Addiction Authors: Sergios Charntikov, Steven T. Pittenger, Ishwor Thapa, Dhundy R. Bastola, Rick A. Bevins, Gurudutt Pendyala Tags: Full length article Source Type: research