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Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats*
Methamphetamine is a potent psychostimulant drug which has been gaining popularity worldwide (United Nations Office on Drugs and Crime, 2009). From a pathological standpoint, chronic methamphetamine abuse has devastating effects on the neural system and predisposes people to movement disorders, stroke, seizures, aggressiveness, memory deficits, and psychosis (Hsieh et al., 2014; Panenka et al., 2013; Yamamoto et al., 2010). These changes can remain for years after discontinued use and may reflect risk factors for relapse (Grant et al., 2012; Scott et al., 2007).
Source: Drug and Alcohol Dependence - April 29, 2015 Category: Addiction Authors: Sergios Charntikov, Steven T. Pittenger, Ishwor Thapa, Dhundy R. Bastola, Rick A. Bevins, Gurudutt Pendyala Tags: Full length article Source Type: research

Methamphetamine dependent individuals show attenuated brain response to pleasant interoceptive stimuli
Conclusions: MD expend fewer brain processing resources during soft touch, a form of positively-valenced interoceptive stimuli, in brain areas that are important for both interoception and reward. Future studies will ascertain if sustained abstinence from methamphetamine use can normalize aberrant neural interoceptive processing.
Source: Drug and Alcohol Dependence - July 16, 2013 Category: Addiction Authors: April C. May, Jennifer L. Stewart, Robyn Migliorini, Susan F. Tapert, Martin P. Paulus Tags: Full Length Reports Source Type: research