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Frailty in relation to the risk of carotid atherosclerosis and cardiovascular events in Chinese community-dwelling older adults: A five-year prospective cohort study
CONCLUSION: Deficit accumulation was closely associated with carotid atherosclerosis risks and strongly predicted five-year CVD events. The frailty index can be used to help identify older adults at high risks of CVD for improved preventive healthcare.PMID:37536575 | DOI:10.1016/j.exger.2023.112266
Source: Experimental Gerontology - August 3, 2023 Category: Geriatrics Authors: Chunxiu Wang Xianghua Fang Zhe Tang Yang Hua Zhongying Zhang Xiang Gu Beibei Liu Kun Yang Xunming Ji Xiaowei Song Source Type: research

Alleviation of ischemic brain injury by exercise preconditioning is associated with modulation of autophagy and mitochondrial dynamics in cerebral cortex of female aged mice
Exp Gerontol. 2023 May 29:112226. doi: 10.1016/j.exger.2023.112226. Online ahead of print.ABSTRACTEvidence from clinical studies and preclinical studies supports that exercise preconditioning can not only reduce the risk of stroke but also improve brain tissue and functional outcome after stroke. It has been demonstrated that autophagy and mitochondrial dynamics are involved in ischemic stroke. However, it is still unclear whether exercise preconditioning-induced neuroprotection against stroke is associated with modulation of autophagy and mitochondrial dynamics. Although age and sex interactively affect ischemic stroke ri...
Source: Experimental Gerontology - May 31, 2023 Category: Geriatrics Authors: Yuan-Yuan Qin Shan-Yao Pan Jia-Ru Dai Qing-Mei Wang Xun Luo Zheng-Hong Qin Li Luo Source Type: research

Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models
This study uses 5 %-Medicare data (1991-2017) to identify, partition, and forecast age-adjusted prevalence and incidence-based mortality of AD as well as their causal components.METHODS: The core underlying methodology is the partitioning analysis that calculates the relative impact each component has on the overall trend as well as intertemporal changes in the strength and direction of these impacts. B-spline functions estimated for all parameters of partitioning models represent the basis for projections of these parameters in future.RESULTS: Prevalence of AD is predicted to be stable between 2017 and 2028 primarily due ...
Source: Experimental Gerontology - February 26, 2023 Category: Geriatrics Authors: I Akushevich A Yashkin M Kovtun J Kravchenko K Arbeev A I Yashin Source Type: research

Longitudinal association of handgrip strength with all-cause and cardiovascular mortality in older adults using a causal framework
Exp Gerontol. 2022 Sep 9:111951. doi: 10.1016/j.exger.2022.111951. Online ahead of print.ABSTRACTTo date, there is no study addressing the time-varying confounding bias in the association of handgrip strength (HGS) with all-cause or cardiovascular mortality. Therefore, we conducted marginal structural models (MSM) to provide causal estimations on the associations of HGS with all-cause and cardiovascular mortality in a representative sample of adults aged 50 years or older. Data from 29 countries including 121,116 participants (276,994 observations; mean age 63.7 years; 56.3 % women) free from prior heart attack or stroke w...
Source: Experimental Gerontology - September 12, 2022 Category: Geriatrics Authors: Rub én López-Bueno Lars Louis Andersen Joaqu ín Calatayud Jos é Casaña Lee Smith Louis Jacob Ai Koyanagi Jos é Francisco López-Gil Borja Del Pozo Cruz Source Type: research

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