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Antiplatelets and Vascular Dementia: A Systematic Review
J Aging Res. 2022 Sep 19;2022:9780067. doi: 10.1155/2022/9780067. eCollection 2022.ABSTRACTVascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology s...
Source: Journal of Aging Research - October 17, 2022 Category: Geriatrics Authors: Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla Source Type: research

Did Generic Clopidogrel Commercialization Affect Trends of ER Consultations and Hospitalizations in the Population Treated with Clopidogrel?
ConclusionsThe population treated with  clopidogrel had similar rates of hospitalizations or ER consultations before and after generics commercialization. However, differences in rates of hospitalizations or ER consultations between generic and brand-name clopidogrel users may represent a drug safety signal which remains to be validated . Using a different study design, permitting adjustment for potential confounders, could be useful in this regard.
Source: Drugs and Aging - May 9, 2019 Category: Geriatrics Source Type: research

Controversies in antiplatelet therapy in the secondary prevention of stroke
Publication date: Available online 19 January 2016 Source:European Geriatric Medicine Author(s): T. Adamek Recurrence of stroke has been estimated at 3–4% yearly after TIA or stroke. There is no clear agreement in choosing antiplatelet therapy at this time. Europeans, Americans and British guidelines have been different. Aspirin is still used in secondary prevention of ischemic stroke, because of the longest experience with the best-achieved results in different studies and low price. Other used drugs are a combination of aspirin and dipyridamole, P2Y12 receptor antagonists – clopidogrel, ticlopidine, prasugrel an...
Source: European Geriatric Medicine - January 20, 2016 Category: Geriatrics Source Type: research

Effects of Antiplatelet Agents on Functional Outcome and Cognitive Status in Patients with Acute Ischemic Stroke
Conclusion The use of antiplatelet agents in acute ischemic stroke may have a favorable effect on functional outcome and cognitive status in patients at 3 months poststroke.
Source: International Journal of Gerontology - November 17, 2014 Category: Geriatrics Source Type: research