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Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
ConclusionsIndividuals in the CVD “belt” had relatively low O3I levels. Since in other settings, a low O3I is associated with increased risk for CVD, this may be one factor contributing to the higher risk for CVD in this region of the US.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 14, 2019 Category: Lipidology Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. BeversdorfAbstractDocosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independent...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 10, 2018 Category: Lipidology Source Type: research

Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Publication date: Available online 21 April 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne StetlerAbstractPolyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain-co...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 5, 2018 Category: Lipidology Source Type: research

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. BeversdorfAbstractDocosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independent...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - July 5, 2018 Category: Lipidology Source Type: research

Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease
Conclusions A circulating pro-inflammatory lipid profile, characterized by high AA:RvD1 and AA:DHA, is associated with acutely symptomatic carotid disease and stroke.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - August 27, 2017 Category: Lipidology Source Type: research

Fatty Acid Transporting Proteins: Roles in Brain Development, Aging, and Stroke
Publication date: Available online 21 April 2017 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): Wenting Zhang, Ruiying Chen, Tuo Yang, Na Xu, Jun Chen, Yanqin Gao, R. Anne Stetler Polyunsaturated fatty acids are required for the brain development and significantly impact aging and stroke. Due to the hydrophobicity of fatty acids, fatty acids transportation related proteins that include fatty acid binding proteins (FABPs), long chain acyl-coA synthase (ACS), fatty acid transportation proteins (FATPs), fatty acid translocase (FAT/CD36) and newly reported major facilitator superfamily domain...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - April 21, 2017 Category: Lipidology Source Type: research

Docosahexaenoic acid (DHA): an essential nutrient and a nutraceutical for brain health and diseases
Publication date: Available online 10 March 2017 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) Author(s): Grace Y. Sun, Agnes Simonyi, Kevin L. Fritsche, Dennis Y. Chuang, Mark Hannink, Zezong Gu, C. Michael Greenlief, Jeffrey K. Yao, James C. Lee, David Q. Beversdorf Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca2+-independ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - March 10, 2017 Category: Lipidology Source Type: research

Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain
Publication date: January 2015 Source:Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), Volume 92 Author(s): M. Lagarde , M. Hachem , N. Bernoud-Hubac , M. Picq , E. Véricel , M. Guichardant 1-acetyl,2-docosahexaenoyl-glycerophosphocholine (AceDoPC) has been made to prevent docosahexaenoyl (DHA) to move to the sn-1 position as it rapidly does when present in 1-lyso,2-docosahexaenoyl-GPC (lysoPC-DHA), an efficient DHA transporter to the brain. When incubated with human blood, AceDoPC behaves closer to lysoPC-DHA than PC-DHA in terms of binding to plasma albumin and lipoproteins, and DHA incorporation into p...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - February 2, 2015 Category: Lipidology Source Type: research