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Procedure: Carotid Endarterectomy
Therapy: Incretin Therapy
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Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of endothelin-1 and activation of CREB. Infusion of GIP increases plasma OPN concentrations in healthy individuals. Plasma endothelin-1 and OPN concentrations are positively correlated in patients with critical limb ischemia. Fasting GIP concentrations are higher in individuals with a history of cardiovascular di...
Source: Diabetes - December 22, 2015 Category: Endocrinology Authors: Berglund, L. M.; Lyssenko, V.; Ladenvall, C.; Kotova, O.; Edsfeldt, A.; Pilgaard, K.; Alkayyali, S.; Brons, C.; Forsblom, C.; Jonsson, A.; Zetterqvist, A. V.; Nitulescu, M.; McDavitt, C. R.; Duner, P.; Stancakova, A.; Kuusisto, J.; Ahlqvist, E.; Lajer, M. Tags: Complications Source Type: research
