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FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation
Autophagy. 2022 Sep 28:1-20. doi: 10.1080/15548627.2022.2116833. Online ahead of print.ABSTRACTProper termination of cell-death-induced neural inflammation is the premise of tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here, we report that FOXP3, the key immune-repressive transcription factor of Tregs, is conditionally expressed in macrophages in stroke lesion. FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. FOXP3+ macrophages are distin...
Source: Autophagy - September 28, 2022 Category: Cytology Authors: Wei Cai Mengyan Hu Chunyi Li Ruizhen Wu Danli Lu Chichu Xie Wei Zhang Tiemei Li Shishi Shen Huipeng Huang Wei Qiu Quentin Liu Yan Lu Zhengqi Lu Source Type: research

PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Abstract Stroke is a major public health problem leading to high rates of death and disability worldwide, but no effective pharmacological therapy is currently available except for the use of PLAT (plasminogen activator, tissue). Here we show that PARP14 (poly (ADP-ribose) polymerase family, member 14) level was significantly increased in the peri-infarct zone of photothrombotic stroke (PT) mice. Genetic knockdown and pharmacological inhibition of PARP14 aggravated functional impairment and increased infarct volume in PT mice, while overexpression of PARP14 displayed the opposite effects. Furthermore, PARP14 was a...
Source: Autophagy - December 15, 2020 Category: Cytology Authors: Tang Y, Liu J, Wang Y, Yang L, Han B, Zhang Y, Bai Y, Shen L, Li M, Jiang T, Ye Q, Yu X, Huang R, Zhang Z, Xu Y, Yao H Tags: Autophagy Source Type: research