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Contemporary Analysis of Incidence and Outcomes of Stent Thrombosis Presenting as ST Elevation Myocardial Infarction in a Primary Percutaneous Coronary Intervention Cohort
There are limited data about the effectiveness of primary percutaneous coronary intervention (PPCI) for stent thrombosis treatment. We aimed to evaluate the prevalence and outcomes of PPCI in patients with ST elevation acute myocardial infarction (STEMI) due to stent thrombosis, and comparing the outcomes with patients treated for de novo coronary thrombosis. This was an observational cohort study of 2,935 patients who underwent PPCI from 2003 to 2011 with follow-up for a median of 3.0 years (interquartile range 1.2 to 4.6). The primary end point was the first major adverse cardiac event (MACE) defined as death, nonfatal ...
Source: The American Journal of Cardiology - September 9, 2013 Category: Cardiology Authors: Daniel A. Jones, Sean Gallagher, Krishnaraj S. Rathod, Mohammed Akhtar, Charles J. Knight, Martin T. Rothman, Akhil Kapur, Anthony Mathur, Ajay K. Jain, Adam D. Timmis, Elliot J. Smith, Andrew Wragg Tags: Coronary Artery Disease Source Type: research

Relation Between Preoperative Renal Dysfunction and Cardiovascular Events (Stroke, Myocardial Infarction, or Heart Failure or Death) Within Three Months of Isolated Coronary Artery Bypass Grafting
Renal dysfunction is related to long-term mortality and myocardial infarction after coronary artery bypass grafting (CABG). We aimed to investigate the association between preoperative renal dysfunction and early risk of stroke, myocardial infarction, or heart failure after CABG. From the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry, we included all 36,284 patients who underwent primary isolated CABG from 2000 to 2008 in Sweden. The Swedish National Inpatient Registry was used to obtain the primary end point, which was rehos...
Source: The American Journal of Cardiology - July 18, 2013 Category: Cardiology Authors: Martin J. Holzmann, Ulrik Sartipy Tags: Coronary Artery Disease Source Type: research

Comparison by Meta-Analysis of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With a Mean Age of ≥70 Years
A paucity of published data evaluating the outcomes of older patients (age ≥70 years) undergoing revascularization for unprotected left main coronary artery disease is available. We performed aggregate data meta-analyses of the clinical outcomes (all-cause mortality, nonfatal myocardial infarction, stroke, repeat revascularization, and major adverse cardiac and cerebrovascular events at 30 days and 12 and 22 months) in studies comparing percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with a mean age of ≥70 years and unprotected left main coronary artery disease. A compre...
Source: The American Journal of Cardiology - May 31, 2013 Category: Cardiology Authors: Mahboob Alam, Salim S. Virani, Saima A. Shahzad, Sahar Siddiqui, Khaleeq H. Siddiqui, Shahzad A. Mumtaz, Neal S. Kleiman, Joseph S. Coselli, Nasser M. Lakkis, Hani Jneid Tags: Coronary Artery Disease Source Type: research

Comparison of the Efficacy and Safety of Two Rivaroxaban Doses in Acute Coronary Syndrome (from ATLAS ACS 2–TIMI 51)
In conclusion, the 2 doses of rivaroxaban reduced cardiovascular events in patients with recent acute coronary syndromes treated with antiplatelet therapies; however, the 2.5-mg dose was associated with lower mortality and fewer bleeding complications than the 5-mg dose. Thus, the addition of rivaroxaban 2.5 mg twice daily offers a more favorable balance of efficacy and safety in patients with recent acute coronary syndromes.
Source: The American Journal of Cardiology - May 28, 2013 Category: Cardiology Authors: Jessica L. Mega, Eugene Braunwald, Stephen D. Wiviott, Sabina A. Murphy, Alexei Plotnikov, Nina Gotcheva, Mikhail Ruda, C. Michael Gibson Tags: Coronary Artery Disease Source Type: research

Development and Validation of a Cardiovascular Risk Assessment Model in Patients With Established Coronary Artery Disease
In conclusion, in patients with established coronary artery disease, the risk of cardiovascular mortality during longer term follow-up can be adequately predicted using the clinical characteristics available at baseline. However, the prediction of nonfatal outcomes, both separately and combined with fatal outcomes, poses major challenges for clinicians and model developers.
Source: The American Journal of Cardiology - April 3, 2013 Category: Cardiology Authors: Linda Battes, Rogier Barendse, Ewout W. Steyerberg, Maarten L. Simoons, Jaap W. Deckers, Daan Nieboer, Michel Bertrand, Roberto Ferrari, Willem J. Remme, Kim Fox, Johanna J.M. Takkenberg, Eric Boersma, Isabella Kardys Tags: Coronary Artery Disease Source Type: research

Alice in Wonderland of Drug-Eluting Stent for Unprotected Left Main Disease
We read the recent meta-analysis by Jang et al of 3 randomized trials and 9 observational studies (with 5,079 patients) comparing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) for unprotected left main coronary artery (ULMCA) disease. At 1-year follow-up, there were trends toward lower risk for death (odds ratio [OR] 0.68, 95% confidence interval [CI] 0.45 to 1.02, p = 0.06) and the composite end point of death, myocardial infarction, or stroke (OR 0.70, 95% CI 0.49 to 1.00, p = 0.05) in the DES group compared to the CABG group. However, target vess...
Source: The American Journal of Cardiology - March 15, 2013 Category: Cardiology Authors: Hisato Takagi, Takuya Umemoto Tags: Readers' Comments Source Type: research

Prehospitalization Antiplatelet Therapy and Outcomes After Saphenous Vein Graft Intervention
In conclusion, prehospital use of antiplatelet therapy was associated with a lower occurrence of major adverse cardiac events after SVG intervention. We did not find that DAPT improved outcomes compared to single antiplatelet therapy.
Source: The American Journal of Cardiology - October 26, 2012 Category: Cardiology Authors: Ralf E. Harskamp, Marcel A. Beijk, Peter Damman, Jan G. Tijssen, Renato D. Lopes, Robbert J. de Winter Tags: Coronary Artery Disease Source Type: research

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