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Source: UCLA Newsroom: Health Sciences
Therapy: Stem Cell Therapy
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Total 10 results found since Jan 2013.
A missing gene makes a big difference in patients ’ recovery from mild stroke
More than 6 million Americans live with disabilities following a stroke. Even mild strokes can leave survivors with arm and leg weakness, poor muscle control and memory lapses that worsen with age. Now UCLA neuroscientists have found that patients born without a gene called CCR5 recover better from mild stroke than patients with the gene. The team partnered with Israeli researchers to study the missing gene ’s effect on brain function.Published Feb. 21 in the journal Cell, the findings could lead to the first pill to reverse the physical and mental aftermath of mild stroke.“This is the first time that a human gene h...
Source: UCLA Newsroom: Health Sciences - February 21, 2019 Category: Universities & Medical Training Source Type: news
Stem cell therapy promotes recovery from stroke and dementia in mice
A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia,a new UCLA study finds.Dementia can arise from multiple conditions, and it is characterized by an array of symptoms including problems with memory, attention, communication and physical coordination. The two most common causes of dementia are Alzheimer ’s disease and white matter strokes — small strokes that accumulate in the connecting areas of the brain.“It’s a vicious cycle: The two leading causes of dementia are almost always seen togeth...
Source: UCLA Newsroom: Health Sciences - April 22, 2021 Category: Universities & Medical Training Source Type: news
Thomas Carmichael elected to the Association of American Physicians
Dr. S. Thomas Carmichael has been elected to the Association of American Physicians, an honor society recognizing exemplary physician-scientists who contribute to clinical medicine through the pursuit of basic science. The newly elected members for 2021 were recognized at the association ’s annual meeting, which was held virtually April 8–10.Carmichael, UCLA ’s Frances Stark Professor of Neurology, is the chair of theneurology department in the David Geffen School of Medicine at UCLA and co-director of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.In his research, Carmichael s...
Source: UCLA Newsroom: Health Sciences - April 9, 2021 Category: Universities & Medical Training Source Type: news
Thomas Carmichael elected to Association of American Physicians
Dr. S. Thomas Carmichael has been elected to the Association of American Physicians, an honor society recognizing exemplary physician-scientists who contribute to clinical medicine through the pursuit of basic science. The newly elected members for 2021 were recognized at the association ’s annual meeting, which was held virtually April 8–10.Carmichael, UCLA ’s Frances Stark Professor of Neurology, is the chair of theneurology department in the David Geffen School of Medicine at UCLA and co-director of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.In his research, Carmichael s...
Source: UCLA Newsroom: Health Sciences - April 9, 2021 Category: Universities & Medical Training Source Type: news
UCLA researchers study genetics ’ role in COVID-19 susceptibility, severity
“One of the most troubling things about COVID-19 is that we have a limited ability to predict how sick a specific individual will get,” said Dr. Daniel Geschwind.Geschwind is the MacDonald Distinguished Professor in Human Genetics at theDavid Geffen School of Medicine at UCLA and a member of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. And he ’s part of a team of UCLA scientists conducting research to learn why certain people get sick from the virus that causes COVID-19 — and why others don’t.Millions of people around the world have been infected with SARS-CoV-2, the v...
Source: UCLA Newsroom: Health Sciences - October 26, 2020 Category: Universities & Medical Training Source Type: news
Fat chance: Scientists unexpectedly discover stress-resistant stem cells in adipose tissue
Researchers from the UCLA Department of Obstetrics and Gynecology have isolated a new population of primitive, stress-resistant human pluripotent stem cells that are easily derived from fat tissue and are able to differentiate into virtually every cell type in the human body without genetic modification.
The cells, called multi-lineage stress-enduring stem cells from adipose tissue (Muse-AT), were discovered by "scientific accident" when a piece of equipment failed in the laboratory, killing all the stem cells in an experiment except the Muse-AT cells.
The UCLA team further discovered that not only are Muse-A...
Source: UCLA Newsroom: Health Sciences - June 5, 2013 Category: Universities & Medical Training Source Type: news
Scientists discover new type of immune cells that are essential for forming heart valves
UCLA researchers have identified for the first time the origin of an immune cell that plays a critical role in the formation of healthy heart valves. The findings could pave the way for new treatments for heart valve disorders, which can be caused by congenital defects, aging or disease.Their study, led by Dr. Atsushi “Austin” Nakano, a UCLA associate professor of molecular, cell and developmental biology and member of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, was published in the journal Developmental Cell.Building on previous research by Nakano, which showed that the embr...
Source: UCLA Newsroom: Health Sciences - February 21, 2019 Category: Universities & Medical Training Source Type: news
Differences in human, mouse brain cells have important implications for disease research
FINDINGSA UCLA-led study comparing brain cells known as astrocytes in humans and mice found that mouse astrocytes are more resilient to oxidative stress, a damaging imbalance that is a mechanism behind many neurological disorders. A lack of oxygen triggers molecular repair mechanisms in these mouse astrocytes but not in human astrocytes. In contrast, inflammation activates immune-response genes in human astrocytes but not mouse astrocytes.BACKGROUNDAlthough the mouse is a ubiquitous laboratory model used in research for neurological diseases, results from studies in mice are not always applicable to humans. In fact, more t...
Source: UCLA Newsroom: Health Sciences - June 25, 2021 Category: Universities & Medical Training Source Type: news
Q & A: Dr. Thomas Rando on preventing age-related diseases and turning discoveries into cures
For Dr. Thomas Rando, the path to becoming a physician-scientist began with something that hedidn ’t learn in high school biology.After one class that touched on the connections between neurons and muscle fibers, Rando took it upon to himself to find all the information he could about how cells communicate through electrical signals.Soon, he began pursuing that interest at Harvard University, where he completed his undergraduate work, a doctorate in cell and developmental biology and his medical degree.Rando joined the neurology faculty at the Stanford University School of Medicine in 1995.There, he founded a clinic to t...
Source: UCLA Newsroom: Health Sciences - December 10, 2021 Category: Universities & Medical Training Source Type: news
Scientists develop blueprint for turning stem cells into sensory interneurons
Key takeaways:Just like the real thing.The stem cell –derived interneurons, which play a role in sensations like touch and pain, are indistinguishable from their real-life counterparts in the body.Tomorrow ’s therapies. In addition to potential treatments for injury-related sensation loss, the discovery could lead to new methods for screening drugs for chronic pain.Moving forward. While stem cells from mice were used in the research, scientists are now working to replicate the findings with human cells.Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have develop...
Source: UCLA Newsroom: Health Sciences - July 19, 2022 Category: Universities & Medical Training Source Type: news
